Patents by Inventor Lingxia Jiang

Lingxia Jiang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYSTEMS AND METHODS FOR ANALYTE ANALYSIS
    Publication number: 20240060985
    Abstract: The present disclosure provides methods and systems for analysis of an analyte. Analysis of an analyte may include contacting an analyte with a binding reagent, which binding reagent may include a binding probe with specificity for the analyte and a nucleic acid molecule. The nucleic acid molecule may be denatured and signals indicative of the denaturing of the analyte may be collected. The collected signals may be used to detect, identify, or quantify the analyte.
    Type: Application
    Filed: December 28, 2021
    Publication date: February 22, 2024
    Inventors: Hien NGUYEN, Ju-Sung HUNG, Lingxia JIANG
  • SYSTEMS AND METHODS FOR ANALYZING A BIOLOGICAL SAMPLE
    Publication number: 20230347353
    Abstract: The present disclosure provides methods and systems for nucleic acid identification. Identification of a nucleic acid molecule may include generating, in a plurality of chambers, a plurality of double-stranded nucleic acid molecules, denaturing the double-stranded nucleic acid molecules, and detecting signals of the denaturation to generate one or more denaturation profiles. The one or more denaturation profiles may be usable to identify nucleic acid molecules. The methods and system described herein may provide for identification of multiple nucleic acid molecules from a single analysis.
    Type: Application
    Filed: June 21, 2021
    Publication date: November 2, 2023
    Inventors: Ju-Sung HUNG, Lingxia JIANG, Robert LIN
  • Fitting melting curve data to determine copy number variation
    Patent number: 11332781
    Abstract: The present invention relates to a method and system for determining Copy Number Variations (CNVs) in a genomic test sample including target amplicons and a reference amplicons. Specifically, nucleic acid melting curves are generated for the test sample. A mathematical model is fitted to each of the nucleic acid melting curves to separate target and reference melting reactions within the measured nucleic acid melting curve. The fitting parameters of the mathematical model are calculated. A CNV of the test sample is determined based on the fitting parameters of the mathematical model corresponding to the target and reference melting reactions.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: May 17, 2022
    Assignee: Canon U.S.A., Inc.
    Inventors: Yang Yang, Sophie Paquerault, Bradley Scott Denney, Lingxia Jiang
  • SYSTEM AND METHOD FOR COPY NUMBER VARIATION ANALYSIS
    Publication number: 20180073070
    Abstract: The present invention relates to a method and system for determining Copy Number Variations (CNVs) in a genomic test sample including target amplicons and a reference amplicons. Specifically, nucleic acid melting curves are generated for the test sample. A mathematical model is fitted to each of the nucleic acid melting curves to separate target and reference melting reactions within the measured nucleic acid melting curve. The fitting parameters of the mathematical model are calculated. A CNV of the test sample is determined based on the fitting parameters of the mathematical model corresponding to the target and reference melting reactions.
    Type: Application
    Filed: October 3, 2017
    Publication date: March 15, 2018
    Inventors: Yang Yang, Sophie Paquerault, Bradley Scott Denney, Lingxia Jiang
  • Methods and systems for sequential determination of genetic mutations and/or variants
    Patent number: 9840737
    Abstract: The present invention relates to methods and systems for genome scanning using high resolution melting analysis for identifying mutations and/or variants in genes of interest.
    Type: Grant
    Filed: June 2, 2011
    Date of Patent: December 12, 2017
    Assignee: Canon U.S. Life Sciences, Inc.
    Inventors: Jacquline Yancy, Lingxia Jiang, Stephanie Buszczak, Renee Howell, Deborah Boles
  • Methods and Systems for Sequential Determination of Genetic Mutations and/or Varients
    Publication number: 20120088236
    Abstract: The present invention relates to methods and systems for genome scanning using high resolution melting analysis for identifying mutations and/or variants in genes of interest.
    Type: Application
    Filed: June 2, 2011
    Publication date: April 12, 2012
    Applicant: CANON U.S. LIFE SCIENCES, INC.
    Inventors: Jacquline Yancy, Lingxia Jiang, Stephanie Buszczak, Renee Howell, Deborah Boles