Abstract: The disclosure features methods of treating RAS protein-related disease using Compound A, or a pharmaceutically acceptable salt thereof. The disclosure also features methods of treating RAS protein-related disease including combinations including Compound A, or a pharmaceutically acceptable salt thereof, and additional therapeutic agents.

Abstract: The present disclosure relates to combination therapies for treating a RAS related disease or disorder (e.g., cancer). In particular, the present disclosure relates to methods of treating a RAS related disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a RAS(ON) inhibitor in combination with one or more additional therapeutic agents, pharmaceutical compositions comprising a therapeutically effective amounts of the same, kits comprising the compositions and methods of use therefor.

Abstract: The present disclosure relates to an end cover assembly, a battery cell, a battery pack and a device. The end cover assembly includes a cover assembly, a terminal assembly, a sealing piece and a first connected flow channel. The cover assembly is provided with an installation hole, and the installation hole penetrates through the cover assembly along an axial direction of the installation hole; the terminal assembly is installed in the installation hole; the sealing piece is configured to seal the installation hole; the first connected flow channel is arranged in at least one of the terminal assembly and the cover assembly, and the first connected flow channel is configured as follows: when the sealing of the sealing piece is invalid, the first connected flow channel enables the inside and the outside of the housing to be communicated through the installation hole.

Abstract: This application provides a battery cell, a battery, and an electrical device. The battery cell includes a shell, an electrode post, an electrode assembly, and an insulation piece. The shell includes a sidewall and a first end wall connected to the sidewall. The electrode post is dielectrically mounted on the first end wall of the shell. The electrode assembly is located in the shell. The electrode assembly includes a first tab. The first tab faces the first end wall and is electrically connected to the electrode post. The insulation piece includes a first insulation portion located between the bottom wall and the first tab, and a second insulation portion peripherally disposed at an outer edge of the first insulation portion and protrudes toward a side at which the electrode assembly is located.

Abstract: Aspects of the disclosure relate to a heat pump system having a selectable bypass flow path that allows a refrigerant to bypass one or more heat exchangers of the heat pump system. The bypass flow path may be used, for example, to provide enhanced thermal energy (e.g., heat) generation by a compressor for a passenger compartment of a vehicle, particularly in relatively low ambient temperatures and/or during fast charging of a vehicle battery.

Abstract: This application provides a battery cell, a battery, and an electrical device. The battery cell includes a shell, an electrode post, an electrode assembly, and an insulation piece. The shell includes a sidewall and a first end wall connected to the sidewall. The electrode post is dielectrically mounted on the first end wall of the shell. The electrode assembly is located in the shell. The electrode assembly includes a first tab. The first tab faces the first end wall and is electrically connected to the electrode post. The insulation piece includes a first insulation portion located between the bottom wall and the first tab, and a second insulation portion peripherally disposed at an outer edge of the first insulation portion and protrudes toward a side at which the electrode assembly is located.

Abstract: The present disclosure relates to an end cover assembly, a battery cell, a battery pack and a device. The end cover assembly includes a cover assembly, a terminal assembly, a sealing piece and a first connected flow channel. The cover assembly is provided with an installation hole, and the installation hole penetrates through the cover assembly along an axial direction of the installation hole; the terminal assembly is installed in the installation hole; the sealing piece is configured to seal the installation hole; the first connected flow channel is arranged in at least one of the terminal assembly and the cover assembly, and the first connected flow channel is configured as follows: when the sealing of the sealing piece is invalid, the first connected flow channel enables the inside and the outside of the housing to be communicated through the installation hole.

Abstract: The present disclosure relates to an end cover assembly, a battery cell, a battery pack and a device. The end cover assembly includes a cover assembly, a terminal assembly, a sealing piece and a first connected flow channel. The cover assembly is provided with an installation hole, and the installation hole penetrates through the cover assembly along an axial direction of the installation hole; the terminal assembly is installed in the installation hole; the sealing piece is configured to seal the installation hole; the first connected flow channel is arranged in at least one of the terminal assembly and the cover assembly, and the first connected flow channel is configured as follows: when the sealing of the sealing piece is invalid, the first connected flow channel enables the inside and the outside of the housing to be communicated through the installation hole.

Abstract: This application provides a battery cell, a battery, and an electrical device. The battery cell includes a shell, an electrode post, an electrode assembly, and an insulation piece. The shell includes a sidewall and a first end wall connected to the sidewall. The electrode post is dielectrically mounted on the first end wall of the shell. The electrode assembly is located in the shell. The electrode assembly includes a first tab. The first tab faces the first end wall and is electrically connected to the electrode post. The insulation piece includes a first insulation portion located between the bottom wall and the first tab, and a second insulation portion peripherally disposed at an outer edge of the first insulation portion and protrudes toward a side at which the electrode assembly is located.

Abstract: Embodiments of the present disclosure provides a battery cell, a battery, an electrical device and a device for preparing a battery cell. The battery cell includes a housing being hollow and including an opening, and an end cover assembly includes an end cover and an insulator. The end cover is configured to be connected to the opening of the housing and at least the part of the end cover is inserted into the housing. A part of the end cover inserted into the housing includes an end surface and a first side surface. The end surface is substantially perpendicular to an insertion direction of the end cover. The first side surface is distributed along a periphery of the end surface and is opposite to an inner wall surface of the housing.

Abstract: An electrode plate assembly includes an electrode plate and a protection layer. The electrode plate includes an electrode plate body. The electrode plate body includes an end region. The protection layer is fixed onto the electrode plate body, and includes a protection layer body section that covers the end region along an extension direction of the end region. The protection layer body section includes a main end face body protection portion and two lateral face body protection portions connected respectively to two sides of the main end face body protection portion. The main end face body protection portion covers a main end face of the end region.

Abstract: A battery cell, a battery, an electric apparatus, and a manufacturing method of battery cell are disclosed. The battery cell includes an electrode assembly, a housing, and a current collecting member, where the electrode assembly is provided with a tab, the housing is configured to accommodate the electrode assembly, and the current collecting member is accommodated in the housing and connected to the tab. The current collecting member is welded to an inner side surface of the housing to form a first welding portion, with a welding depth formed by the first welding portion on the housing being less than a thickness of the housing. In this way, during welding, the housing is not punctured, and the first welding portion cannot penetrate through the housing.

Abstract: The present application relates to the field of batteries, in particular to a battery, a battery module and an electric equipment. The battery of the present application includes: a connection member, including a first connection portion configured to be electrically connected with an electrode assembly and a second connection portion configured to be electrically connected with an electrode terminal, and the first connection portion is in a folded state along a crease relative to the second connection portion; the crease is arranged between a first end face and a second end face of the first connection portion; and when the connection member is in an expanded state, the second end face and the first end face are arranged along a length direction.

Abstract: A battery cell includes a housing, an electrode terminal, an electrode assembly and a current collection member. The electrode terminal is disposed on the housing. The electrode assembly is accommodated in the housing, and an end of the electrode assembly facing towards the electrode terminal is provided with a first electrode tab. The current collection member is connected to the first electrode tab, and at least a part of the current collection member is located lateral to the electrode terminal towards the first electrode tab, abuts with and is connected to the electrode terminal.

Abstract: The present application relates to a secondary battery, a battery module and an apparatus. The secondary battery includes an electrode assembly and a casing. The electrode assembly includes a main body portion and a tab portion, the tab portion extending out from the main body portion along an end of the main body portion and including an outer peripheral surface. The casing includes an accommodating hole for accommodating the electrode assembly. The casing includes a limiting protrusion. The outer peripheral surface extends around an axis of the accommodating hole. The limiting protrusion protrudes toward the tab portion and presses against the outer peripheral surface of the tab portion. The limiting protrusion is adapted to limit a position of the tab portion. The secondary battery provided by the present application can reduce the possibility of fatigue fracture of the adapting piece.

Abstract: The present application relates to a secondary battery, a battery module and an apparatus. The secondary battery includes an electrode assembly and a casing. The electrode assembly includes a main body portion and a tab portion, the tab portion extending out from the main body portion along an end of the main body portion and including an outer peripheral surface. The casing includes an accommodating hole for accommodating the electrode assembly. The casing includes a limiting protrusion. The outer peripheral surface extends around an axis of the accommodating hole. The limiting protrusion protrudes toward the tab portion and presses against the outer peripheral surface of the tab portion. The limiting protrusion is adapted to limit a position of the tab portion. The secondary battery provided by the present application can reduce the possibility of fatigue fracture of the adapting piece.

Abstract: A secondary battery, a battery pack, and an electric device. The secondary battery includes: a case with an inner cavity in which an electrolyte is included; a cap assembly covering an opening of the case; and an electrode assembly located in the inner cavity, the electrode assembly including an electrode unit and tabs, and along a length direction, the electrode unit including two side portions disposed oppositely, the tabs extending from the side portions; a connecting component configured to connect the tabs and the cap assembly; a flow guiding component located between a corresponding connecting component and a corresponding side portion, being connected to the connecting component and provided with an avoiding portion configured to avoid the tabs, and being in contact with the electrolyte, at least part of the flow guiding component being in contact with the corresponding side portion, and the flow guiding component.

Abstract: The embodiments of the present application provide a battery cell, a battery and a power consuming device, which fall within the technical field of batteries. The battery cell includes an electrode assembly and a shell. The shell accommodates the electrode assembly, and includes a wall portion that is arranged opposite the electrode assembly in a thickness direction of the wall portion. The wall portion is provided with a first reinforcement portion in a protruding manner, the first reinforcement portion extends in a circumferential direction of the wall portion, the wall portion includes a first region located on an outer circumferential side of the first reinforcement portion, and a weak portion is formed in the first region and is configured to rupture during pressure relief of the battery cell. The first reinforcement portion has an effect of reinforcing the wall portion to strengthen the weak portion.

Abstract: Described are an electrode assembly, and a method for manufacturing the electrode assembly, the electrode assembly being configured for a secondary battery. The electrode assembly includes a main portion and a tab, the tab is located at an end portion of the main portion and is connected to the main portion; and the tab includes a shaping guide portion and a shaping deformation area, and the shaping guide portion guides the tab to generate predetermined deformation during shaping so as to form the shaping deformation area. By arranging the shaping guide portion on the tab, when a tab end face is shaped, the shaping guide portion guides the tab to generate roughly regular deformation, thereby forming the compact and flat tab end face. The arrangement of the shaping guide portion reduces the force required for the shrinking deformation of the tab and avoids damage or misalignment of an electrode plate.

Abstract: The present disclosure relates to a secondary battery, a battery module, and a device using the secondary battery as a power source. The secondary battery includes a casing and a top cover for connecting with the casing. The casing includes an end portion provided with an opening. The top cover is used to cover the opening of the casing. The top cover includes an inserting portion extending into the casing from the opening. A plurality of notches are provided on an inner side of the end portion of the casing or on a side wall of the inserting portion facing the casing. In the secondary battery, the battery module, and the device using the secondary battery as a power source according to the present disclosure, the secondary battery can reduce the possibility of short circuit occurring in the electrode assembly and improve the operational safety of the secondary battery.