Abstract: A phase frequency detector-based high-precision feedback frequency measurement apparatus and method: a Field Programmable Gate Array (FGPA) roughly measures a frequency fx of a measured time-frequency pulse by an equal-precision frequency measurement method; a Direct Digital Synthesizer (DDS) automatically synthesizes a frequency fx? according to the fx roughly measured by the FPGA; the fx and the fx? are sent to a phase frequency detector for performing phase frequency detection and then sent to the FPGA after passing through a charge pump, a low-pass filter circuit, and an (Analogue-to-Digital) A/D converter; the FPGA processes a frequency difference obtained by the phase frequency detector and then transmits the processed frequency difference to the DDS to form a negative feedback frequency measurement system so that the DDS continuously adjusts the fx? according to a frequency difference measurement result until the output of the DDS is stable.

Abstract: This disclosure provides an unmanned survey vessel with an anti-overturning structure and an anti-overturning method of same, and relates to the anti-overturning technique field of unmanned survey vessels. The unmanned survey vessel includes a vessel body and a plurality of buoys. The vessel body is a hollow frame of which a middle is provided with a discharge space. An uptight rod is vertically fixed at an upper-end of the tail part of the vessel body. A supporting beam is horizontally fixed at an upper-end of the upright rod. The supporting beam extends to a bow of the vessel. A rectangular notch is formed in one end, close to the bow, of the supporting beam. One end close to the bow inside the rectangular notch is rotatably provided with a guide rod through a pin shaft. The plurality of buoys are equally divided into two groups which are adjustably arranged on two side walls in the advancing direction of the vessel body respectively.

Abstract: An easy-to-assemble mounting rack for a deformation detection device for a steel structure and an assembling method thereof are provided. The easy-to-assemble mounting rack includes mounting parts including a back mounting plate, an operating rod, an adjusting seat, a ball-shaped block and an upright rod. The upright rod is vertically fixed at the bottom end face of the adjusting seat. A ball-shaped hole is formed in the adjusting seat. The ball-shaped block is rotatably embedded in the ball-shaped hole. A plug-in hole is formed in a radial direction of the ball-shaped block. One end of the operating rod slidably penetrates through the plug-in hole and is detachably connected with the back mounting plate. Screw holes directly opposite to the mounting holes of the deformation detection device are formed on the back mounting plate. The other end of the operating rod is fixedly sleeved with a counterweight plate.

Abstract: Disclosed is a salt form of an isoquinolinone type compound as a ROCK protein kinase inhibitor and a preparation method therefor, and use of the salt form in the preparation of a medicament for treating glaucoma or ocular hypertension is further included.

Abstract: Disclosed are an acetophenone oxime compound and a preparation method therefor, and specifically disclosed are a compound as shown in formula (II) and a pharmaceutically acceptable salt thereof.

Abstract: Disclosed are a series of benzo 2-azaspiro[4.4]nonane compounds, and specifically disclosed are a compound as represented by formula (P) or a pharmaceutically acceptable salt thereof.

Abstract: Salt types, crystal forms, and preparation methods for benzopyrazole compounds as RHO kinase inhibitors. Specifically, disclosed are hydrochloride and acetate of compounds of formula (I) and crystal forms thereof, as well as application of the salt types and the crystal forms in preparation of RHO inhibitor drugs.

Abstract: Provided is a cyclopropylamine compound as lysine-specific demethylase 1 (LSD1) inhibitor, and a use thereof in preparation of drug for treating diseases associated with LSD1. The cyclopropylamine compound is a compound represented by formula (I), an isomer thereof, and a pharmaceutically acceptable salt thereof.

Abstract: Disclosed are a series of benzo 2-azaspiro[4.4]nonane compounds, and specifically disclosed are a compound as represented by formula (P) or a pharmaceutically acceptable salt thereof.

Abstract: Disclosed in the present invention are a series of tricyclic compounds, and particularly disclosed are a compound shown in formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: Disclosed are a series of isoquinolone derivatives as ROCK protein kinase inhibitors and uses thereof in preparing medicaments for ROCK protein kinase inhibitor-related glaucoma or ocular hypertension diseases. Specially, disclosed are a compound of formula (I), an isomer thereof or a pharmaceutically acceptable salt thereof.

Abstract: Methods, systems, electronic devices, and computer-readable storage media for image normalization processing are provided. In one aspect, an image normalization processing method includes: normalizing a feature map by respectively using K normalization factors to obtain K candidate normalized feature maps; for each of the K normalization factors, determining a first weight value for the normalization factor; and determining a target normalized feature map corresponding to the feature map based on the candidate normalized feature map corresponding to each of the K normalization factors and the first weight value for each of the K normalization factors. The K candidate normalized feature maps and the K normalization factors have a one-to-one correspondence, and K is an integer greater than 1.

Abstract: A biaryl compound. Specifically disclosed is a compound represented by formula (I) and a pharmaceutically acceptable salt thereof.

Abstract: Disclosed are a class of pyrazole compounds and applications thereof in the preparation of a medicament for treating related diseases. Specifically, related are a compound represented by formula (II) and a pharmaceutically acceptable salt thereof.

Abstract: Salt types, crystal forms, and preparation methods for benzopyrazole compounds as RHO kinase inhibitors. Specifically, disclosed are hydrochloride and acetate of compounds of formula (I) and crystal forms thereof, as well as application of the salt types and the crystal forms in preparation of RHO inhibitor drugs.

Abstract: Provided are a crystal form of a tricyclic compound and a preparation process thereof. Also provided is an application of the crystal form in preparing a drug for treating a disease related to a sphingosine-1-phosphate subtype 1 (S1P1) receptor.

Abstract: Disclosed are pyrrolotriazine compounds which act as a mitogen-activated protein kinase interacting kinase (MNK) inhibitor, and the use thereof in the preparation of a mitogen-activated protein kinase interacting kinase inhibitor drug. Specifically disclosed are compounds represented by formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: Disclosed is a class of porcupine inhibitors, specifically a compound as represented by formula (I), and a pharmaceutically acceptable salt or an isomer thereof.