Patents by Inventor Linh Q. Le

Linh Q. Le has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Botulinum Neurotoxin Proteins and Methods to Engineer and Generate Same
    Publication number: 20230332126
    Abstract: Botulinum neurotoxin proteins and fragments thereof that bind and/or cleave a noncanonical substrate, e.g., non-neuronal SNARE proteins such as human SNAP-23 (hSNAP-23) and SNAP-29 (hSNAP-29), are described.
    Type: Application
    Filed: August 24, 2021
    Publication date: October 19, 2023
    Inventors: Gregory A. Weiss, Amy D. Brideau-Andersen, Rebekah P. Dyer, Lance E. Steward, Linh Q. Le, Gaetano Speciale, David C. Rupp, Birgitte P.S. Jacky, Madison H. Fletcher, Sudipta Majumdar
  • BOTULINUM NEUROTOXIN FOR TREATMENT OF DISORDERS ASSOCIATED WITH MELANOCYTE HYPERACTIVITY AND/OR EXCESS MELANIN
    Publication number: 20230302103
    Abstract: Methods for treating melanin-related afflictions of the skin, such as hyperpigmentation, are provided. The methods comprise administering a composition comprising BoNT/DC.
    Type: Application
    Filed: December 21, 2022
    Publication date: September 28, 2023
    Inventors: Birgitte P.S. Jacky, Shizazh Z. Malik, Joanne Wang, Yi Liu, Amy Brideau-Andersen, Lance E. Steward, Linh Q. Le, Edward C. Hsia
  • BOTULINUM NEUROTOXIN FOR TREATMENT OF DISORDERS ASSOCIATED WITH MELANOCYTE HYPERACTIVITY AND/OR EXCESS MELANIN
    Publication number: 20210162027
    Abstract: Methods for treating melanin-related afflictions of the skin, such as hyperpigmentation, are provided. The methods comprise administering a composition comprising BoNT/DC.
    Type: Application
    Filed: February 3, 2021
    Publication date: June 3, 2021
    Inventors: Birgitte P.S. Jacky, Shizazh Z. Malik, Joanne Wang, Yi Liu, Amy Brideau-Andersen, Lance E. Steward, Linh Q. Le, Edward C. Hsia
  • Botulinum neurotoxin for treatment of disorders associated with melanocyte hyperactivity and/or excess melanin
    Patent number: 10912823
    Abstract: Methods for treating melanin-related afflictions of the skin, such as hyperpigmentation, are provided. The methods comprise administering a composition comprising BoNT/DC.
    Type: Grant
    Filed: May 30, 2018
    Date of Patent: February 9, 2021
    Assignee: Allergan, Inc.
    Inventors: Birgitte P.S. Jacky, Shiazah Z. Malik, Joanne Wang, Yi Liu, Amy Brideau-Andersen, Lance E. Steward, Linh Q. Le, Edward C. Hsai
  • BOTULINUM NEUROTOXIN FOR TREATMENT OF DISORDERS ASSOCIATED WITH MELANOCYTE HYPERACTIVITY AND/OR EXCESS MELANIN
    Publication number: 20180344820
    Abstract: Methods for treating melanin-related afflictions of the skin, such as hyperpigmentation, are provided. The methods comprise administering a composition comprising BoNT/DC.
    Type: Application
    Filed: May 30, 2018
    Publication date: December 6, 2018
    Inventors: Birgitte P.S. Jacky, Shizazh Z. Malik, Joanne Wang, Yi Liu, Amy Brideau-Andersen, Lance E. Steward, Linh Q. Le, Edward C. Hsai
  • Methods of intracellular conversion of single-chain proteins into their di-chain form
    Patent number: 9938514
    Abstract: The present specification discloses expression constructs comprising single-chain proteins comprising a di-chain loop region comprising an exogenous protease cleavage site and a protease that can cleave the exogenous protease cleavage site located within the di-chain loop, cell compositions comprising such expression construct, and intracellular methods of converting the single-chain protein into its di-chain form.
    Type: Grant
    Filed: May 16, 2016
    Date of Patent: April 10, 2018
    Assignee: Allergan, Inc.
    Inventors: Sanjiv Ghanshani, Linh Q. Le, Yi Liu, Lance E. Steward
  • Methods Of Intracellular Conversion Of Single-Chain Proteins Into Their Di-Chain Form
    Publication number: 20160319265
    Abstract: The present specification discloses expression constructs comprising single-chain proteins comprising a di-chain loop region comprising an exogenous protease cleavage site and a protease that can cleave the exogenous protease cleavage site located within the di-chain loop, cell compositions comprising such expression construct, and intracellular methods of converting the single-chain protein into its di-chain form.
    Type: Application
    Filed: May 16, 2016
    Publication date: November 3, 2016
    Inventors: Sanjiv Ghanshani, Linh Q. Le, Yi Liu, Lance E. Steward
  • Methods of intracellular conversion of single-chain proteins into their di-chain form
    Patent number: 9340813
    Abstract: The present specification discloses expression constructs comprising single-chain proteins comprising a di-chain loop region comprising an exogenous protease cleavage site and a protease that can cleave the exogenous protease cleavage site located within the di-chain loop, cell compositions comprising such expression construct, and intracellular methods of converting the single-chain protein into its di-chain form.
    Type: Grant
    Filed: September 26, 2013
    Date of Patent: May 17, 2016
    Assignee: Allergan, Inc.
    Inventors: Sanjiv Ghanshani, Linh Q. Le, Yi Liu, Lance E. Steward
  • MODIFIED CLOSTRIDIAL TOXINS COMPRISING AN INTEGRATED PROTEASE CLEAVAGE SITE-BINDING DOMAIN
    Publication number: 20140127784
    Abstract: The present specification discloses modified Clostridial toxins, compositions comprising an integrated protease cleavage site-binding domain, polynucleotide molecules encoding such modified Clostridial toxins and compositions comprising di-chain forms of such modified Clostridial toxins.
    Type: Application
    Filed: January 2, 2014
    Publication date: May 8, 2014
    Applicant: Allergan, Inc.
    Inventors: Sanjiv Ghanshani, Linh Q. Le, Yi Liu, Lance E. Steward
  • Methods Of Intracellular Conversion Of Single-Chain Proteins Into Their Di-Chain Form
    Publication number: 20140030759
    Abstract: The present specification discloses expression constructs comprising single-chain proteins comprising a di-chain loop region comprising an exogenous protease cleavage site and a protease that can cleave the exogenous protease cleavage site located within the di-chain loop, cell compositions comprising such expression construct, and intracellular methods of converting the single-chain protein into its di-chain form.
    Type: Application
    Filed: September 26, 2013
    Publication date: January 30, 2014
    Applicant: Allergan, Inc.
    Inventors: Sanjiv Ghanshani, Linh Q. Le, Yi Liu, Lance E. Steward
  • Methods of intracellular conversion of single-chain proteins into their di-chain form
    Patent number: 8546108
    Abstract: The present specification discloses expression constructs comprising single-chain proteins comprising a di-chain loop region comprising an exogenous protease cleavage site and a protease that can cleave the exogenous protease cleavage site located within the di-chain loop, cell compositions comprising such expression construct, and intracellular methods of converting the single-chain protein into its di-chain form.
    Type: Grant
    Filed: January 24, 2011
    Date of Patent: October 1, 2013
    Assignee: Allergan, Inc.
    Inventors: Sanjiv Ghanshani, Linh Q. Le, Yi Liu, Lance E. Steward
  • Methods Of Intracellular Conversion Of Single-Chain Proteins Into Their Di-Chain Form
    Publication number: 20120295330
    Abstract: The present specification discloses expression constructs comprising single-chain proteins comprising a di-chain loop region comprising an exogenous protease cleavage site and a protease that can cleave the exogenous protease cleavage site located within the di-chain loop, cell compositions comprising such expression construct, and intracellular methods of converting the single-chain protein into its di-chain form.
    Type: Application
    Filed: January 24, 2011
    Publication date: November 22, 2012
    Applicant: ALLERGAN, INC.
    Inventors: Sanjiv Ghanshani, Linh Q. Le, Yi Liu, Lance E. Steward
  • Modified Clostridial Toxins Comprising an Integrated Protease Cleavage Site-Binding Domain
    Publication number: 20110189162
    Abstract: The present specification discloses modified Clostridial toxins, compositions comprising an integrated protease cleavage site-binding domain, polynucleotide molecules encoding such modified Clostridial toxins and compositions comprising di-chain forms of such modified Clostridial toxins.
    Type: Application
    Filed: December 16, 2010
    Publication date: August 4, 2011
    Applicant: ALLERGAN, INC.
    Inventors: Sanjiv Ghanshani, Linh Q. Le, Yi Liu, Lance E. Steward