Abstract: A transcatheter heart valve prosthesis and a method of assembling the transcatheter heart valve prosthesis are disclosed. The heart valve prosthesis includes a valve-skirt assembly having an inner skirt, a frame, an outer wrap backing and an outer wrap. The method includes: tacking the valve-skirt assembly within the frame; attaching the inner skirt below commissure posts of the frame; attaching commissures of the valve component to the commissure posts; attaching a plurality of outer wrap backings to the inner skirt; attaching the outer wrap backings and the inner skirt to the frame; attaching tissue bumpers to struts in an outflow section of the frame; attaching an outer wrap and the inner skirt to the frame; attaching the outer wrap to the inner skirt proximate inflow edges thereof; and attaching the outer wrap to the inner skirt and to the outer wrap backings proximate respective outflow edges thereof.

Abstract: In various embodiments, a computer animation application automatically solves inverse kinematic problems when generating object animations. The computer animation application determines a target vector based on a target value for a joint parameter associated with a joint chain and at least one of a target position or a target orientation for an end-effector associated with the joint chain. The computer animation application executes a trained machine learning model on the target vector to generate a predicted vector that includes data associated with multiple joint parameters associated with the joint chain.

Abstract: In various embodiments, an inverse kinematic (IK) modeling application generates models that are used to solve IK problems for object animations. The IK modeling application generates configuration vectors based on a set of joint parameters associated with a joint chain. The IK modeling application executes forward kinematic operation(s) on the joint chain based on the configuration vectors to generate target vectors. Each target vector includes data associated with at least one of a position or an orientation for an end-effector associated with the joint chain. The IK modeling application performs one or more machine learning (ML) operations on an ML model based on the configuration vectors and the target vectors to generate a trained ML model that computes a predicted joint vector associated with the joint chain based on at least one of a target position or a target orientation for the end-effector.

Abstract: A refilling device for an article of an aerosol provision system includes refilling control circuitry. The refilling control circuitry is configured to facilitate the transfer of aerosol-generating material from a reservoir to the article when the article is coupled to the refilling device. The refilling control circuitry causes a value of a counter stored on the reservoir to be updated in response to the transfer of the aerosol-generating material. The value of the counter is indicative of the amount of an aerosol generating material in the reservoir.

Abstract: A refilling device for an article of an aerosol provision system includes an article interface configured to receive the article and refilling control circuitry. The refilling circuitry is configured to read, from the article in response to the article being received by the article interface, an indication of a number of times the article has been refilled with aerosol generating material, and transmit, to a remote data store using a wireless communications protocol, the indication.

Abstract: A computer is configured to receive, from a refilling device for an article of an aerosol provision system associated with the computer via a remote data store using a wireless communications protocol, an indication of a number of times the article of the aerosol provision system has been refilled with aerosol generating material. The computer is then configured to provide the indication to a user of the computer.

Abstract: A refilling device for an article of an aerosol provision system includes refilling control circuitry. The refilling control circuitry is configured to facilitate the transfer of aerosol-generating material from a reservoir coupled to the refilling device to the article and cause a value of a counter to be updated in response to the transfer of the aerosol-generating material. The value of the counter is indicative of a number of times the article has been refilled. The refilling control circuitry determines if the article is expired based on a comparison between the updated value of the counter and a refill limit and writes data to computer-readable memory indicating that the article is expired in response to determining that the article is expired.

Abstract: A refilling device for an article of an aerosol provision system includes comprises refilling control circuitry. The refilling control circuitry is configured to read data from the article in response to the article being received by the refilling device and prevent a transfer of aerosol generating material from a reservoir coupled to the refilling device to the article in response to determining that the data indicates that the article has expired.

Abstract: A recombinant Pichia pastoris strain which is genetically modified for highly expressing pediocin PA-1 and secreted into a medium so that the pediocin PA-1 is easily collected and purified from the culture medium. The obtained pediocin PA-1 has specific antimicrobial activities against Listeria monocytogenes ATCC 13932 and several other bacteria strains.

Abstract: The present disclosure relates generally to systems and methods for facilitating proactive two-way communication sessions. One example includes proactively sending a message, where when the message is received, the message initiates a conversation with a user across a first messaging platform. When it is dynamically determined that the first messaging platform is unavailable, a list of prioritized alternative messaging platforms is dynamically generated. A prioritized second messaging platform is selected from the list of prioritized alternative messaging platforms, and the message is dynamically modified in accordance with standards associated with the prioritized second messaging platform. When a response is then received after sending the modified message on the prioritized second messaging platform, an agent is selected from a pool of agents to respond.

Abstract: Large vessel occlusion (LVO) detection and treatment prediction is provided via receiving a patient image depicting a medical scan of a patient; in response to identifying, via a first model, an LVO in the patient image, determining, via the first model whether the LVO is acute or chronic; in response to determining that the LVO is acute, determining via a second model different from the first model, a predicted treatment outcome for an immediate medical intervention for the LVO; and responsive to determining a successful treatment outcome for the LVO, assigning the immediate medical intervention to the patient.

Abstract: The present disclosure relates to a housing for an aerosol provision system. The housing comprising a reservoir for an electrically conductive aerosolisable material, wherein the potential difference between any two exposed and/or exposable surfaces of one or more metal components which are contained in the housing, is from 0 mV to about 35 mV, wherein the two surfaces are capable of simultaneously being in contact with the aerosolisable material. Also disclosed is a cartomiser comprising a reservoir containing an electrically conductive aerosolisable material, and two exposed and/or exposable surfaces of one or more metal components, wherein the two surfaces are capable of simultaneously being in contact with the electrically conductive aerosolisable material and wherein the change in dissolved metal content of the electrically conductive aerosolisable material after storage of the cartomiser for about 1 to about 8 weeks at about 40° C. is between 0 and about 20%.

Abstract: A device for modulating the amplitude of an incident laser radiation of wavelength ?i is provided.

Abstract: A method for accelerating a convolution operation includes receiving from an I/O interface, a first data set and a second data set. Transforming the first data set into a first converted data set, the first converted data set having the first format. Transforming the second data set into a second converted data set, the second converted data set having the second format. Loading into a convolution functional unit, the first converted data set and the second converted data set, where the convolution functional unit is configured to receive a first data in a first format, to receive a second data in a second format, and to output a third data in a third format. Receiving, by the task scheduler from the convolution functional unit, a result in the third format.

Abstract: A surgical instrument may include a multi-lumen catheter configured to be inserted within the tissue. The multi-lumen catheter may include a first lumen that may enable a flow of a fluid, a second lumen that may receive a navigation probe that may facilitate an ability to locate the region of interest within the tissue, and an expandable membrane that may be situated toward a distal end of the first lumen to form an expandable cavity. The expandable cavity may be configured to expand or contract based on the flow of the fluid through the first lumen. The surgical instrument may include a fluid line, coupled to the first lumen, that may supply the fluid to the first lumen to enable the expandable cavity to expand or withdraw the fluid from the first lumen to enable the expandable cavity to contract.

Abstract: The present disclosure relates generally to systems and methods for facilitating proactive two-way communication sessions. One example includes proactively sending a message, where when the message is received, the message initiates a conversation with a user across a first messaging platform. When it is dynamically determined that the first messaging platform is unavailable, a list of prioritized alternative messaging platforms is dynamically generated. A prioritized second messaging platform is selected from the list of prioritized alternative messaging platforms, and the message is dynamically modified in accordance with standards associated with the prioritized second messaging platform. When a response is then received after sending the modified message on the prioritized second messaging platform, an agent is selected from a pool of agents to respond.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for extracting entities from conversation transcript data. One of the methods includes obtaining a conversation transcript sequence, processing the conversation transcript sequence using a span detection neural network configured to generate a set of text token spans; and for each text token span: processing a span representation using an entity name neural network to generate an entity name probability distribution over a set of entity names, each probability in the entity name probability distribution representing a likelihood that a corresponding entity name is a name of the entity referenced by the text token span; and processing the span representation using an entity status neural network to generate an entity status probability distribution over a set of entity statuses.

Abstract: The present invention provides novel reagents and a cloning procedure based on homologous recombination for the site-directed cloning of a DNA fragment to a vector at designed site(s). The cloning reagents are made of mixture of extracts from at least two different cell types, preferably a mixture made of extracts from wild-type E. coli and S. cerevisiae. Due to the activity of the mixture of cell extracts, recombination occurs between the 3? and 5?-ends of the target DNA and at the ends of linearized vector, which facilitates in-frame construction of expression vectors.

Abstract: The present disclosure relates generally to systems and methods for facilitating proactive two-way communication sessions. One example includes proactively sending a message, where when the message is received, the message initiates a conversation with a user across a first messaging platform. When it is dynamically determined that the first messaging platform is unavailable, a list of prioritized alternative messaging platforms is dynamically generated. A prioritized second messaging platform is selected from the list of prioritized alternative messaging platforms, and the message is dynamically modified in accordance with standards associated with the prioritized second messaging platform. When a response is then received after sending the modified message on the prioritized second messaging platform, an agent is selected from a pool of agents to respond.

Abstract: The present disclosure relates generally to systems and methods for facilitating proactive two-way communication sessions. One example includes proactively sending a message, where when the message is received, the message initiates a conversation with a user across a first messaging platform. When it is dynamically determined that the first messaging platform is unavailable, a list of prioritized alternative messaging platforms is dynamically generated. A prioritized second messaging platform is selected from the list of prioritized alternative messaging platforms, and the message is dynamically modified in accordance with standards associated with the prioritized second messaging platform. When a response is then received after sending the modified message on the prioritized second messaging platform, an agent is selected from a pool of agents to respond.