Abstract: An asymmetric GPR84 antagonist and a use thereof, the GPR84 antagonist having a structure as shown in formula I. The compound represented by formula I has GPR84 antagonistic activity, can competitively inhibit GPR84 agonist-induced receptor activation, and can be used to treat various diseases associated with the high expression or hyperexcitability of GPR84, such as multiple sclerosis, inflammatory bowel disease, organ fibrosis, arthritis, etc.

Abstract: A four-cylinder compressor, including a hollow base placed horizontally, a motor body fixed in the base, a cam mechanism in transmission connection to output shafts at two ends of the motor body and two cylinder groups arranged at the base. The cylinder groups are in transmission connection with the cam mechanism, each including a first cylinder and a second cylinder. The first cylinder and the second cylinder are fixedly arranged opposite to each other on the base along the vertical direction. The two first cylinders are connected, and the two second cylinders are connected.

Abstract: The present invention relates to a GPR84 receptor antagonist and use thereof. The GPR84 receptor antagonist of the present invention has a structure as represented by formula (I), the definitions of R1, R2, R3, R4, L1, L2, L3, L4, L5, L6, Y, Z, and rings A, B, C, and D are as described in the description and claims. The GPR84 receptor antagonist of the present invention can competitively inhibit the activation of the receptor caused by an agonist of GPR84, and can be used in the preparation of a medicament for treating related diseases caused by high expression or high excitability of GPR84 receptor, the diseases including multiple sclerosis, inflammatory bowel disease, arthritis and the like.

Abstract: The present invention relates to a GPR84 receptor antagonist and use thereof. The GPR84 receptor antagonist of the present invention has a structure as represented by formula (I), the definitions of R1, R2, R3, R4, L1, L2, L3, L4, L5, L6, Y, Z, and rings A, B, C, and D are as described in the description and claims. The GPR84 receptor antagonist of the present invention can competitively inhibit the activation of the receptor caused by an agonist of GPR84, and can be used in the preparation of a medicament for treating related diseases caused by high expression or high excitability of GPR84 receptor, the diseases including multiple sclerosis, inflammatory bowel disease, arthritis and the like.

Abstract: The present invention relates to a class of compounds represented by the formula I, or pharmaceutically acceptable salts thereof, methods for their preparation, and application as small molecule tools that function as GPR84 agonists, and their use in preparing a medicament for the treatment of septicemia.