Patents by Inventor Lin-Hua Zhang

Lin-Hua Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Intermediates useful for synthesis of heteroaryl-substituted urea compounds, and processes of making same
    Patent number: 6894173
    Abstract: Disclosed are novel processes and novel intermediate compounds for preparing aryl-and heteroaryl-substituted urea compounds of the formula(I) wherein Ar1, Ar2, L, Q and X are described herein. The product compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases.
    Type: Grant
    Filed: February 10, 2003
    Date of Patent: May 17, 2005
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Lin-Hua Zhang, Lei Zhu
  • Process for synthesis of heteroaryl-substituted urea compounds useful as antiinflammatory agents
    Patent number: 6835832
    Abstract: Disclosed are novel processes and novel intermediate compounds for preparing aryl-and heteroaryl-substituted urea compounds of the formula(I) wherein Ar1, Ar2, L, Q and X are described herein. The product compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases.
    Type: Grant
    Filed: February 10, 2003
    Date of Patent: December 28, 2004
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Lin-Hua Zhang, Lei Zhu
  • Process for synthesis of heteroaryl-substituted urea compounds useful as antiinflammatory agents
    Patent number: 6774233
    Abstract: Disclosed are novel processes and novel intermediate compounds for preparing aryl- and heteroaryl-substituted urea compounds of the formula(I) wherein Ar1, Ar2, L, Q and X are described herein. The product compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases.
    Type: Grant
    Filed: February 10, 2003
    Date of Patent: August 10, 2004
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Lin-Hua Zhang, Lei Zhu
  • Polymorph and process for preparing same
    Patent number: 6753426
    Abstract: Disclosed are processes, polymorph and intermediate compounds for preparing aryl-and heteroaryl-substituted urea compounds of the formula(I) wherein Ar1, Ar2, L, Q and X are described herein. The product compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases.
    Type: Grant
    Filed: November 20, 2002
    Date of Patent: June 22, 2004
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Lin-Hua Zhang, Lei Zhu
  • Process for synthesis of heteroaryl-substituted urea compounds useful as antiinflammatory agents
    Publication number: 20030181718
    Abstract: Disclosed are novel processes and novel intermediate compounds for preparing aryl-and heteroaryl-substituted urea compounds of the formula(I) wherein Ar1, Ar2, L, Q and X are described herein. The product compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases.
    Type: Application
    Filed: February 10, 2003
    Publication date: September 25, 2003
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Lin-Hua Zhang, Lei Zhu
  • Process for synthesis of heteroaryl-substituted urea compounds useful as antiinflammatory agents
    Publication number: 20030166930
    Abstract: Disclosed are novel processes and novel intermediate compounds for preparing aryl- and heteroaryl-substituted urea compounds of the formula(I) wherein Ar1, Ar2, L, Q and X are described herein. The product compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases.
    Type: Application
    Filed: February 10, 2003
    Publication date: September 4, 2003
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Lin-Hua Zhang, Lei Zhu
  • Process for synthesis of heteroaryl-substituted urea compounds useful as antiinflammatory agents
    Publication number: 20030166931
    Abstract: Disclosed are novel processes and novel intermediate compounds for preparing aryl-and heteroaryl-substituted urea compounds of the formula(I) wherein Ar1, Ar2, L, Q and X are described herein. The product compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases.
    Type: Application
    Filed: February 10, 2003
    Publication date: September 4, 2003
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Lin-Hua Zhang, Lei Zhu
  • Process for synthesis of heteroaryl-substituted urea compounds useful as antiinflammatory agents
    Patent number: 6583282
    Abstract: Disclosed are novel processes and novel intermediate compounds for preparing aryl- and heteroaryl-substituted urea compounds of the formula (I) wherein Ar1, Ar2, L, Q and X are described herein. The product compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases.
    Type: Grant
    Filed: July 6, 2000
    Date of Patent: June 24, 2003
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Lin-Hua Zhang, Lei Zhu
  • Polymorph and process for preparing same
    Publication number: 20030109703
    Abstract: Disclosed are processes, polymorph and intermediate compounds for preparing aryl- and heteroaryl-substituted urea compounds of the formula(I) wherein Ar1, Ar2, L, Q and X are described herein. The product compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases.
    Type: Application
    Filed: November 20, 2002
    Publication date: June 12, 2003
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Lin-Hua Zhang, Lei Zhu
  • Aromatic heterocyclic compounds as antiinflammatory agents
    Publication number: 20020058678
    Abstract: Disclosed are novel aromatic heterocyclic compounds of the formula(I) wherein Ar1, Ar2, L, Q and X are described herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are processes of making such compounds.
    Type: Application
    Filed: June 12, 2001
    Publication date: May 16, 2002
    Inventors: Pier F. Cirillo, Thomas A. Gilmore, Eugene R. Hickey, John R. Regan, Lin-Hua Zhang
  • Method of treating cytokine mediated diseases or conditions
    Patent number: 6333325
    Abstract: Disclosed are novel aromatic heterocyclic compounds of the formula(I) wherein Ar1,Ar2,L,Q and X are described herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are processes of making such compounds.
    Type: Grant
    Filed: May 31, 2001
    Date of Patent: December 25, 2001
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Pier F. Cirillo, Thomas A. Gilmore, Eugene R. Hickey, John R. Regan, Lin-Hua Zhang
  • Aromatic heterocyclic compound as antiinflammatory agents
    Patent number: 6319921
    Abstract: Disclosed are novel aromatic heterocyclic compounds of the formula (I) wherein Ar1, Ar2, L, Q and X are described herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are processes of making such compounds.
    Type: Grant
    Filed: January 18, 2000
    Date of Patent: November 20, 2001
    Assignee: Boerhinger Ingelheim Pharmaceuticals, Inc.
    Inventors: Pier F. Cirillo, Thomas A. Gilmore, Eugene R. Hickey, John R. Regan, Lin-Hua Zhang
  • Crystalline roxifiban
    Patent number: 6306886
    Abstract: The potent platelet glycoprotein IIb/IIIa antagonist, roxifiban, is produced in crystalline form. Crystalline roxifiban exists in two polymorphic forms, designated Form 1 and Form 2. These polymorphic forms are characterized by x-ray powder diffraction and solid-state carbon NMR. Pharmaceutical compositions and methods for the treatment or prevention of diseases mediated by platelet aggregation are described.
    Type: Grant
    Filed: June 15, 1998
    Date of Patent: October 23, 2001
    Assignee: DuPont Pharmaceuticals Company
    Inventors: Michael Blaise Maurin, Philip Ma, David John Meloni, Jaan A. Pesti, Lucius Thomas Rossano, Randall K. Ward, Jianguo Yin, Lin Hua Zhang, Goss S. Kauffman
  • Polycyclo heterocyclic derivatives as antiinflammatory agents
    Patent number: 6242453
    Abstract: Disclosed are novel aromatic polycyclo heterocyclic compounds of the formula(I) wherein A, B, C, G, Ar, L, Q and X are described herein. The compounds are useful in pharmaceutical compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes of making such compounds.
    Type: Grant
    Filed: February 14, 2000
    Date of Patent: June 5, 2001
    Assignee: Boehringer Ingelheim Pharmaceuticals, Inc
    Inventors: Pier F. Cirillo, Eugene R. Hickey, John R. Regan, Lin-Hua Zhang
  • Dynamic resolution of isoxazoline thioesters to isoxazoline carboxylic acids
    Patent number: 6022977
    Abstract: The present invention relates generally to a novel method for preparation of substituted isoxazolin-5-yl acetic acid in high optical purity from a stereoisomeric mixture of an esterified substituted isoxazolin-5-yl acetate. The products are useful in the synthesis of compounds for pharmaceuticals, especially the treatment of thrombolytic disorders, and agricultural products.
    Type: Grant
    Filed: March 25, 1998
    Date of Patent: February 8, 2000
    Assignee: DuPont Pharmaceuticals Company
    Inventors: Lin-Hua Zhang, Luigi Anzalone, Jaan A. Pesti, Jianguo Yin
  • Processes and intermediate compounds for the preparation of platelet glycoprotein IIb/IIIa inhibitors
    Patent number: 5817749
    Abstract: This invention provides processes for the synthesis of platelet glycoprotein IIb/IIIa inhibitors and intermediate compounds useful in said processes.
    Type: Grant
    Filed: January 12, 1995
    Date of Patent: October 6, 1998
    Assignee: DuPont Pharmaceuticals Company
    Inventors: Lin-Hua Zhang, Philip Ma, William Frank DeGrado
  • Method for the synthesis of anthrapyrazolones
    Patent number: 5618944
    Abstract: This invention relates to compounds, including 5-chloro-2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethyl]-7-[2,4,6-trimethylphen yl)methoxy]anthra[1,9-cd]pyrazol-6(2H)-one and analogs thereof, which are useful as intermediates for the synthesis of anthrapyrazolone anticancer agents, including losoxantrone. This invention also relates to methods for the synthesis of anthrapyrazolone anticancer agents, including losoxantrone.
    Type: Grant
    Filed: January 10, 1995
    Date of Patent: April 8, 1997
    Assignee: The DuPont Merck Pharmaceutical Company
    Inventors: Lin-Hua Zhang, Joseph Auerbach
  • Intermediates for the synthesis of anthrapyrazolone anticancer agents
    Patent number: 5393886
    Abstract: This invention relates to compounds, including 5-chloro-2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethyl]-7-[2,4,6-trimethylphen yl)methoxy]anthra[1,9-cd]pyrazol-6(2H)-one and analogs thereof, which are useful as intermediates for the synthesis of anthrapyrazolone anticancer agents, including losoxantrone. This invention also relates to methods for the synthesis of anthrapyrazolone anticancer agents, including losoxantrone.
    Type: Grant
    Filed: October 25, 1993
    Date of Patent: February 28, 1995
    Assignee: The Du Pont Merck Pharmaceutical Company
    Inventors: Lin-Hua Zhang, Joseph Auerbach