Abstract: A measurement probe includes a substrate and six electrodes embedded in the substrate, including a first electrode, a second electrode, a third electrode, a fourth electrode, a fifth electrode and a sixth electrode, the first electrode is arranged opposite to the fourth electrode, and/or the second electrode is arranged opposite to the fifth electrode, and/or and the third electrode is arrange opposite to the sixth electrode. Excitations are applied between any opposite electrodes, the electrodes are circumferentially distributed on the substrate, and at least two pairs of electrodes are in axial symmetry. The probe can carry out stable signal collection and has simple structure. The measurement system and the measurement method can reduce the influence of the contact impedance between the probe and the measured tissues and also improve the accuracy of judging whether the probe is located at the juncture of human body tissues or animal body tissues.