Abstract: A method of establishing a transistor statistical model based on an artificial neural network system comprising receiving a first data set and generating a nominal model of a baseline transistor by the artificial neural network system based on the first data set; screening neurons in the artificial neural network system based on the first data set and the nominal model to obtain final variational neurons; obtaining distribution of weights of the final variational neurons and distribution of threshold voltages based on variation of the nominal model with respect to weights of the final variational neurons, variation of the nominal model with respect to the threshold voltages, distribution of the drain-source current and distribution of the gate-source voltage in the first data set; and establishing the transistor statistical model based on the nominal model, the distribution of weights of the final variational neurons and the distribution of the threshold voltages.

Abstract: The application of PDCD4 as a drug treatment target for anti-depression and/or anti-anxiety disorders has been proved by experimental research that the increase of PDCD4 is an important factor leading to depression in the process of stress; PDCD4 as a target to inhibit its expression or function can play a good antidepressant role, and has no effect on normal physiological state. Therefore, PDCD4 can be used as a target in the preparation and screening of antidepressant and/or anxiolytic drugs, which has a broad application prospect.

Abstract: The application of PDCD4 as a drug treatment target for anti-depression and/or anti-anxiety disorders has been proved by experimental research that the increase of PDCD4 is an important factor leading to depression in the process of stress; PDCD4 as a target to inhibit its expression or function can play a good antidepressant role, and has no effect on normal physiological state. Therefore, PDCD4 can be used as a target in the preparation and screening of antidepressant and/or anxiolytic drugs, which has a broad application prospect.