Abstract: Synthetic polymers, e.g., synthetic heparin mimetics, are provided, including hydrogel compositions incorporating the synthetic polymers. Methods of making and using the synthetic polymers are also provided.

Abstract: Systems and methods for motion sensitized and motion suppressed quantitative imaging of a subject are provided as a train of interlaced radio frequency (RF) and magnetic field gradient pulses. Non-selective Delay Alternating with Nutation for Tailored Excitation (DANTE) pulse trains may be used in combination with gradient pulses and short repetition times as motion-sensitive preparation modules. In one or more embodiments, the systems and methods may use a train of low flip angle radio frequency (RF) pulses in combination with a blipped field gradient pulse between each RF pulse, repeated regularly. While the longitudinal magnetization of static tissue is mostly preserved, moving spins are largely (or fully) suppressed since they fail to establish transverse steady state due to a spoiling effect caused by flow along the applied gradient.

Abstract: A method of measuring a parameter in a sample by imaging at least a portion of the sample using a spin-echo single-point imaging (SE-SPI) pulse sequence. This method involves applying a pure phase encoding to the SE-SPI pulse sequence, acquiring a multiplicity of echoes, and determining the spatially resolved T2 distribution. In another embodiment, individual echoes are separately phase encoded in a multi-echo acquisition and the SE-SPI pulse sequence is a hybrid SE-SPI sequence. In another embodiment, an external force can be used to build up a distribution of saturations in the sample, and a T2 distribution can be measured for the sample, which is then used to determine a parameter of the sample. A spatially resolved T2 distribution can also be measured and a resulting spatially resolved T2 distribution used to determine the T2 distribution as a function of capillary pressure.

Abstract: A method of measuring a parameter in a sample by imaging at least a portion of the sample using a spin-echo single-point imaging (SE-SPI) pulse sequence. This method involves applying a pure phase encoding to the SE-SPI pulse sequence, acquiring a multiplicity of echoes, and determining the spatially resolved T2 distribution. In another embodiment, individual echoes are separately phase encoded in a multi-echo acquisition and the SE-SPI pulse sequence is a hybrid SE-SPI sequence. In another embodiment, an external force can be used to build up a distribution of saturations in the sample, and a T2 distribution can be measured for the sample, which is then used to determine a parameter of the sample. A spatially resolved T2 distribution can also be measured and a resulting spatially resolved T2 distribution used to determine the T2 distribution as a function of capillary pressure.