Abstract: The present invention relates to the field of biomedicine, and discloses a pyrazolopyrimidine compound, a pharmaceutical composition, and an application therefor, the oxygen-containing substituted pyrazolopyrimidine compound having the structure shown in formula (I). The oxygen-containing substituted pyrazolopyrimidine compound having the structure shown in formula (I) provided in the present invention or a pharmaceutically acceptable salt, a stereoisomer, a geometric isomer, a tautomer, a nitrogen oxide, a hydrate, a solvate, a metabolite, or a prodrug thereof demonstrate excellent inhibitory activity against TRK kinase, and demonstrate good anti-tumour activity at the animal level.