Abstract: An acid salt and a crystal form of a pyrazole-containing polycyclic derivative represented by formula (I-a), and a preparation method therefor, a pharmaceutical composition containing a therapeutically effective amount of the crystal form, and an intermediate for preparing the derivative. In particular, the present invention relates to the use of the salt and the crystal form of the compound represented by general formula (I-a) as a P2X3 inhibitor in the preparation of a drug for treating neurogenic diseases.

Abstract: A salt and a crystal form relating to a nitrogen-containing heterocyclic derivative, a preparation method therefor and an application thereof. In particular, the present invention relates to a salt and crystal form of a compound represented by general formula (I), a preparation method therefor, a pharmaceutical composition comprising a therapeutically effective amount of the crystal form, and a use thereof as a KRAS G12C mutation inhibitor in the treatment of diseases or conditions such as leukemia, neuroblastoma, melanoma, breast cancer, lung cancer and colon cancer. Each substituent in the general formula (I) is the same as defined in the description.

Abstract: The present invention relates to a crystal form of a free base of an inhibitor containing a bicyclic ring derivative and a preparation method and an application of the crystal form, and in particular to a crystal form of a compound represented by general formula (I), a preparation method and a pharmaceutical composition containing a therapeutically effective amount of the compound crystal form, and an application of the crystal form used as an RET inhibitor in treatment of diseases such as cancer, inflammation, chronic liver diseases, diabetes, cardiovascular diseases and AIDS.

Abstract: The present invention relates to a crystal form of the free alkali of nitrogen-containing aromatic derivatives. In particular, the present invention relates to a crystal form of the compound represented by the general formula (I), its preparation method and a pharmaceutical composition containing a therapeutically effective amount of the crystal form, and the use thereof as a protein tyrosine phosphatase-2C (SHP2) inhibitor in the treatment of diseases or conditions such as leukemia, neuroblastoma, melanoma, breast cancer, lung cancer and colorectal cancer.

Abstract: A three fused ring derivative-containing salt and a crystal form thereof. In particular, the present invention relates to a compound having general formula (I), a crystal form thereof, a preparation method therefor, a pharmaceutical composition containing a therapeutically effective amount of the compound and the crystal form thereof, and use thereof in the preparation of a medicament for treating PI3K-mediated related diseases.

Abstract: The present invention relates to a steroid derivative regulator, in particular to a compound of formula (I), a salt and crystal form thereof, a preparation method therefor, a pharmaceutical composition containing a therapeutically effective amount of the crystal form, and an application thereof as a GABAA receptor regulator in treatment of depression, convulsions, Parkinsonism and nervous system diseases.

Abstract: An apparatus for determining a condition of an exhaust gas recirculation (EGR) cooler of an internal combustion engine includes a clean EGR cooler module that is configured to estimate the temperature of exhaust gas exiting a clean EGR cooler. The apparatus also includes a fouled EGR cooler module that is configured estimate the temperature of exhaust gas exiting a fouled EGR cooler. Further, the apparatus includes an EGR cooler effectiveness module that is configured to determine a normalized effectiveness of the EGR cooler based on the estimated temperature of exhaust gas exiting a clean EGR cooler and the estimated temperature of exhaust gas exiting a fouled EGR cooler. Additionally, the apparatus includes an EGR cooler condition module that is configured to determine a condition of the EGR cooler based on the normalized effectiveness of the EGR cooler.

Abstract: A system is described for producing an elevated exhaust temperature and reduced NOx output for an engine. The system includes an internal combustion engine having a common rail fuel system, an exhaust pressure modulation device for the internal combustion engine, and a controller structured to functionally execute operations for elevating the exhaust temperature and reducing the NOx output. The controller determines a desired engine outlet exhaust temperature, an engine speed, and an engine load. In response to the desired engine outlet exhaust gas temperature, the engine speed, and the engine load, the controller determines an exhaust pressure increase command and a fuel injection command including at least one post-injection event. The common rail fuel system is responsive to the fuel injection command, and the exhaust pressure modulation device is responsive to the exhaust pressure increase command.

Abstract: An apparatus for determining a condition of an exhaust gas recirculation (EGR) cooler of an internal combustion engine includes a clean EGR cooler module that is configured to estimate the temperature of exhaust gas exiting a clean EGR cooler. The apparatus also includes a fouled EGR cooler module that is configured estimate the temperature of exhaust gas exiting a fouled EGR cooler. Further, the apparatus includes an EGR cooler effectiveness module that is configured to determine a normalized effectiveness of the EGR cooler based on the estimated temperature of exhaust gas exiting a clean EGR cooler and the estimated temperature of exhaust gas exiting a fouled EGR cooler. Additionally, the apparatus includes an EGR cooler condition module that is configured to determine a condition of the EGR cooler based on the normalized effectiveness of the EGR cooler.

Abstract: A method and system for controlling a continuously variable transmission (CVT). In one embodiment, the method includes receiving vehicle operation data. The method also includes controlling engine and transmission operations based on the vehicle operation data, fuel efficiency data, and CVT efficiency data.

Abstract: A system is provided for enhancing aftertreatment regeneration capability. The system includes an internal combustion engine producing an exhaust gas stream and an aftertreatment component that treats the exhaust gas stream, where the aftertreatment component includes a desired inlet exhaust gas temperature. The system includes an exhaust gas pressure device that modulates an exhaust pressure value, and a fuel injection system that provides a post-injection event. The system includes a controller that provides an exhaust pressure command and a fuel injection command in response to determining that a temperature of the exhaust gas stream is lower than the desired inlet exhaust gas temperature. The exhaust gas pressure device is responsive to the exhaust pressure command and the fuel injection system is responsive to the fuel injection command.

Abstract: A method is disclosed including operations to interpret an engine load level for a reciprocating piston internal combustion engine. In response to determining the engine load level is less than 40% of a maximum engine load level, the method further includes operations to performing a first fuel injection event including less than 25% of a combustion fuel amount, the first fuel injection event occurring before 10 degrees after top dead center (TDC), to perform a second fuel injection event including between 15% and 65% of the combustion fuel amount, the second fuel injection event occurring after 10 degrees after TDC, and to perform third fuel injection event comprising between 10% and 85% of the combustion fuel amount, the third fuel injection event occurring before 63 degrees after TDC.

Abstract: A method is disclosed including operations to interpret an engine load level for a reciprocating piston internal combustion engine. In response to determining the engine load level is less than 40% of a maximum engine load level, the method further includes operations to performing a first fuel injection event including less than 25% of a combustion fuel amount, the first fuel injection event occurring before 10 degrees after top dead center (TDC), to perform a second fuel injection event including between 15% and 65% of the combustion fuel amount, the second fuel injection event occurring after 10 degrees after TDC, and to perform third fuel injection event comprising between 10% and 85% of the combustion fuel amount, the third fuel injection event occurring before 63 degrees after TDC.

Abstract: A method is disclosed including operations to interpret an engine load level for a reciprocating piston internal combustion engine. In response to determining the engine load level is less than 40% of a maximum engine load level, the method further includes operations to performing a first fuel injection event including less than 25% of a combustion fuel amount, the first fuel injection event occurring before 10 degrees after top dead center (TDC), to perform a second fuel injection event including between 15% and 65% of the combustion fuel amount, the second fuel injection event occurring after 10 degrees after TDC, and to perform third fuel injection event comprising between 10% and 85% of the combustion fuel amount, the third fuel injection event occurring before 63 degrees after TDC.

Abstract: Various embodiments of an apparatus, system, and method are disclosed for managing regeneration event characteristics. For example, according to one embodiment, an apparatus for controlling the temperature of the output exhaust of an internal combustion engine for a regeneration event on a particulate matter filter includes a regeneration module, a turbocharger thermal management module, a fuel injection thermal management module, and an air intake thermal management module. The regeneration module determines a desired particulate matter filter inlet exhaust gas temperature for a regeneration event. The turbocharger thermal management module determines a variable geometry turbine (VGT) device position strategy. The fuel injection thermal management module determines a fuel injection strategy. The air intake thermal management module determines an intake throttle position strategy.

Abstract: Various embodiments of an apparatus, system, and method are disclosed for managing regeneration event characteristics. For example, according to one embodiment, an apparatus for controlling the temperature of the outlet exhaust of an internal combustion engine for a regeneration event on a particulate matter filter includes a regeneration module and a fuel injection strategy module. The regeneration module is configured to determine a desired engine outlet exhaust gas temperature for a regeneration event. The fuel injection strategy module is configured to determine a regeneration fuel injection strategy for achieving the desired engine outlet exhaust gas temperature. The regeneration fuel injection strategy includes a main fuel injection, a first heat post-injection, and a second heat post-injection. In certain implementations, the fuel injection strategy also includes at least one or two non-heat post-injections for achieving a desired particulate filter inlet exhaust gas temperature.

Abstract: A system is described for producing an elevated exhaust temperature and reduced NOx output for an engine. The system includes an internal combustion engine having a common rail fuel system, an exhaust pressure modulation device for the internal combustion engine, and a controller structured to functionally execute operations for elevating the exhaust temperature and reducing the NOx output. The controller determines a desired engine outlet exhaust temperature, an engine speed, and an engine load. In response to the desired engine outlet exhaust gas temperature, the engine speed, and the engine load, the controller determines an exhaust pressure increase command and a fuel injection command including at least one post-injection event. The common rail fuel system is responsive to the fuel injection command, and the exhaust pressure modulation device is responsive to the exhaust pressure increase command.

Abstract: A system is provided for enhancing aftertreatment regeneration capability. The system includes an internal combustion engine producing an exhaust gas stream and an aftertreatment component that treats the exhaust gas stream, where the aftertreatment component includes a desired inlet exhaust gas temperature. The system includes an exhaust gas pressure device that modulates an exhaust pressure value, and a fuel injection system that provides a post-injection event. The system includes a controller that provides an exhaust pressure command and a fuel injection command in response to determining that a temperature of the exhaust gas stream is lower than the desired inlet exhaust gas temperature. The exhaust gas pressure device is responsive to the exhaust pressure command and the fuel injection system is responsive to the fuel injection command.

Abstract: An apparatus that includes a calibration module, a conditions module, and an output module. The calibration module includes a plurality of calibration tables that includes a top-rated torque curve and bottom-rated torque curve for each of a plurality of predetermined engine operating modes of an engine emissions family. The top-rated torque curve corresponds to a top horsepower rating of the engine emissions family and the bottom-rated torque curve corresponds to a bottom horsepower rating of the engine emissions family. The conditions module is configured to determine operating conditions of the internal combustion engine. The output module is configured to command at least one component of the engine to achieve a desired engine output exhaust gas emissions value based at least partially on the operating conditions of the internal combustion engine and a comparison between the top horsepower rating and bottom horsepower rating of the engine emissions family.

Abstract: A method is disclosed for thermal management of an engine comprising a continuously variable transmission. The method includes an engine capability module storing a torque-speed map comprising a first region where the engine inefficiently regenerates an aftertreatment device, a second region where the engine efficiently regenerates the aftertreatment device, and a third region where the engine is not capable of regenerating the aftertreatment device. The method further includes an aftertreatment determination module determining a regeneration index, an operating conditions module determining an engine speed and an engine load, and a speed-load adjustment module adjusting a speed-load target. The method further includes the speed-load adjustment module adjusting the speed-load target to a preferred region along equal power curves of the torque-speed map based on the regeneration index.