Patents by Inventor Lionel Breton

Lionel Breton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11987808
    Abstract: The present invention relates to the field of stem cell biology, in particular the linage specific differentiation of pluripotent or multipotent stem cells. Specifically described are methods to direct the lineage specific differentiation of hiPSC to sensitive neurons or neuronal fibers innervating the human skin, such as neural crest stem cells (NCPCs) and here called peripheral sensory neurons (PSNs) using novel culture conditions. It is also described a method for screening a biological agent in vitro. The PSNs obtained using the methods of the present invention are further contemplated for various uses including, but limited to, use in in vitro tests or disease modelling, such as drug discovery assays, cell therapy on a higher scale, detecting a range of skin irritants and other compounds of interest, for studying skin aging mechanism, and for producing a dermocosmetic product.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: May 21, 2024
    Assignee: L'OREAL
    Inventors: Rodrigo De Vecchi, Stevens Kastrup Rehen, Marilia Zaluar, Lionel Breton
  • Publication number: 20210340177
    Abstract: Two synthetic tetrapeptides having a high binding affinity to human muscular nicotinic acetylcholine receptor (HmnAChR) are provided. A composition for inhibiting contraction of muscle cells is also provided. The composition comprises an effective amount of one of these two peptides. Also provided is a method for inhibiting contraction of muscle cells, which method comprises treating muscle cells with an effective amount of the composition. Further provided is a method for inducing proliferation of epidermal cells, which method comprises treating the epidermal cells with an effective amount of the composition. The epidermal cells may be human epidermal keratinocytes (HEKs).
    Type: Application
    Filed: April 30, 2020
    Publication date: November 4, 2021
    Inventors: Rodrigo DE VECCHI, Lionel BRETON, Leonardo de Azevedo CALDERON, Fernando ZANCHI, Aleff Ferreira FRANCISCO
  • Patent number: 11154731
    Abstract: Cosmetic use of an effective amount of a lysate of at least one microorganism of the genus Bifidobacterium species and/or one of its fractions in treating and/or preventing dryness and/or associated disorders of a keratinous substance.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: October 26, 2021
    Assignee: L'OREAL
    Inventors: Isabelle Castiel, Lionel Breton, Audrey Gueniche
  • Publication number: 20210270813
    Abstract: The present invention relates to a kit comprising a co-culture microdevice containing peripheral sensory neurons (PSN) and human epidermal keratinocytes (HEK) in a cell culture adapted for both cell types. It is also described a method for screening an active compound using the kit according to the present invention, as well as the use thereof for in vitro dmg tests and for producing a cosmetic product for various dermatological applications, such as atopic dermatitis, sensitive skin, photoaging, wound healing and epidermal thickness in aged skin.
    Type: Application
    Filed: June 28, 2018
    Publication date: September 2, 2021
    Inventors: Rodrigo DE VECCHI, Lionel BRETON, Charbel BOUEZ, Vanja DAKIC
  • Publication number: 20200216803
    Abstract: The present invention relates to the field of stem cell biology, in particular the linage specific differentiation of pluripotent or multipotent stem cells. Specifically described are methods to direct the lineage specific differentiation of hiPSC to sensitive neurons or neuronal fibers innervating the human skin, such as neural crest stem cells (NCPCs) and here called peripheral sensory neurons (PSNs) using novel culture conditions. It is also described a method for screening a biological agent in vitro. The PSNs obtained using the methods of the present invention are further contemplated for various uses including, but limited to, use in in vitro tests or disease modelling, such as drug discovery assays, cell therapy on a higher scale, detecting a range of skin irritants and other compounds of interest, for studying skin aging mechanism, and for producing a dermocosmetic product.
    Type: Application
    Filed: June 20, 2017
    Publication date: July 9, 2020
    Inventors: Rodrigo DE VECCHI, Stevens Kastrup REHEN, Marilia ZALUAR, Lionel BRETON
  • Patent number: 10688139
    Abstract: An orally administrable composition for the photoprotection of the skin which comprises the combination of i) at least one probiotic lactic acid bacterium or a culture supernatant thereof, and ii) at least one carotenoid or derivative, included into an orally acceptable carrier.
    Type: Grant
    Filed: July 2, 2007
    Date of Patent: June 23, 2020
    Assignee: SOCIÉTÉ DES PRODUITS NESTLÉ S.A.
    Inventors: Lionel Breton, Isabelle Bureau-Franz, Chantal Fanchon
  • Patent number: 10456429
    Abstract: The present invention relates to the topical use of Bifidobacterium longum subsp. longum CNCM I-2618, as a pro-pigmenting agent, in particular in the prevention and/or treatment of alterations of skin and/or hair color homogeneity and for creating a uniform complexion.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: October 29, 2019
    Assignees: L'OREAL, NESTEC S.A.
    Inventors: Lionel Breton, Audrey Gueniche, Michela Zuccolo, Annick Mercenier, Guénolé Prioult
  • Patent number: 10238897
    Abstract: Cosmetic use of an effective amount of at least one lysate of at least one microorganism of the genus Bifidobacterium species and/or a fraction thereof, for preventing and/or treating a skin disorder in the case of sensitive skin.
    Type: Grant
    Filed: August 28, 2008
    Date of Patent: March 26, 2019
    Assignee: L'OREAL
    Inventors: Isabelle Castiel, Lionel Breton, Audrey Gueniche
  • Publication number: 20180243590
    Abstract: Cosmetic use of an effective amount of a lysate of at least one microorganism of the genus Bifidobacterium species and/or one of its fractions in treating and/or preventing dryness and/or associated disorders of a keratinous substance.
    Type: Application
    Filed: May 1, 2018
    Publication date: August 30, 2018
    Applicant: L'OREAL
    Inventors: Isabelle CASTIEL, Lionel BRETON, Audrey GUENICHE
  • Patent number: 9770474
    Abstract: Red blotches on the skin such as those associated with environmental stresses, or red blotches associated with a skin disorder, for example those occurring during rosacea, are treated/reduced by administering to individuals afflicted therewith, thus effective amounts of at least one extract of a non-photosynthetic and non-fruiting filamentous bacterium cultured in a medium which includes at least one non-sulfurous mineral and/or thermal water, e.g., an extract derived from the bacterium Vitreoscilla filiformis, in particular the strain ATCC 15551, cultured in a medium enriched with water from La Roche Posay.
    Type: Grant
    Filed: July 17, 2008
    Date of Patent: September 26, 2017
    Assignee: L'Oreal
    Inventors: Audrey Gueniche, Lionel Breton
  • Patent number: 9393266
    Abstract: Bags and/or dark circles around the eyes of individuals afflicted therewith are reduced by administering to such individuals thus effective amounts of at least one extract of a non-photosynthetic and non-fruiting filamentous bacterium cultured in a medium which includes at least one non-sulfurous mineral and/or thermal water, e.g., an extract derived from the bacterium Vitreoscilla filiformis, in particular the strain ATCC 15551, cultured in a medium enriched with water from La Roche Posay.
    Type: Grant
    Filed: July 17, 2008
    Date of Patent: July 19, 2016
    Assignee: L'Oreal
    Inventors: Lionel Breton, Audrey Gueniche
  • Patent number: 9326927
    Abstract: The invention relates to the nontherapeutic cosmetic use of at least one cannabinoid compound chosen from the compounds corresponding to general formula (I): and also the geometric isomers and optical isomers thereof, the cosmetically acceptable acid or base salts thereof, and the hydrates thereof; in which compounds of formula (I): R1 represents a hydrogen atom or a C1-C30 alkyl group; it being possible for said alkyl group to be optionally substituted with a hydroxyl (OH) group; R2 represents a halogen atom or a group chosen from hydroxyl, thiol (SH), and amino optionally substituted with one or two C1-C6 alkyl groups; R3 and R4 form, together with the carbon atom which bears them, an oxo group or else R3 and R4 represent a hydrogen atom; R5 represents a hydrogen atom or a C1-C6 alkyl group; X represents a heteroatom chosen from oxygen and sulfur atoms and the divalent group —N(R6)—, with R6 representing a hydrogen atom or a C1-C6 alkyl group; represents a single or double bond; n is 1, 2 or 3, prefe
    Type: Grant
    Filed: August 3, 2012
    Date of Patent: May 3, 2016
    Assignee: L'OREAL
    Inventors: Michela Zuccolo, Roland Jourdain, Lionel Breton, Mauro Maccarrone
  • Publication number: 20150343002
    Abstract: The present invention relates to the topical use of Bifidobacterium longum subsp. longum CNCM I-2618, as a pro-pigmenting agent, in particular in the prevention and/or treatment of alterations of skin and/or hair color homogeneity and for creating a uniform complexion.
    Type: Application
    Filed: December 18, 2013
    Publication date: December 3, 2015
    Inventors: Lionel Breton, Audrey Gueniche, Michela Zuccolo, Annick Mercenier, Guénolé Prioult
  • Publication number: 20150297506
    Abstract: The present invention relates to the oral use of Bifidobacterium longum subsp. longum CNCM I-2618, as a pro-pigmenting agent, in particular in the prevention and/or treatment of alterations of skin and/or hair color homogeneity.
    Type: Application
    Filed: December 18, 2013
    Publication date: October 22, 2015
    Inventors: Lionel BRETON, Audrey GUENICHE, Michela ZUCCOLO, Annick MERCENIER, Guénolé PRIOULT
  • Patent number: 9138408
    Abstract: The invention relates to a method of treating and preventing ageing of the pilosebaceous unit and/or alopecia in human through the administration of taurine and/or hypotaurine and/or the acceptable salts thereof in an oral composition. Specifically, the invention relates to a method of treating and preventing miniaturization of the hair follicle. The invention also relates to the use of polyphenols to achieve these same ends. Finally, the invention relates to oral compositions that include polyphenols or taurine and/or hypotaurine and/or the acceptable salts thereof as active ingredients.
    Type: Grant
    Filed: June 23, 2003
    Date of Patent: September 22, 2015
    Assignees: L'OREAL, NESTEC S.A.
    Inventors: Albert Duranton, Lionel Breton
  • Patent number: 9125934
    Abstract: Sensitive skin, mucous membranes and scalps are treated by administering to individuals in need of such treatment, thus effective amounts of at least one extract of a non-photosynthetic and non-fruiting filamentous bacterium cultured in a medium which includes at least one non-sulfurous mineral and/or thermal water, e.g., an extract derived from the bacterium Vitreoscilla filiformis, in particular the strain ATCC 15551, cultured in a medium enriched with water from La Roche Posay.
    Type: Grant
    Filed: July 17, 2008
    Date of Patent: September 8, 2015
    Assignee: L'Oreal
    Inventors: Lionel Breton, Yann Mahe, Richard Martin
  • Publication number: 20150152486
    Abstract: The present invention relates to a method of diagnosing a pellicular state in a subject, to a screening method of identifying an antidandruff agent, and to kits and nucleic acid arrays useful for said methods.
    Type: Application
    Filed: July 13, 2012
    Publication date: June 4, 2015
    Applicant: L'Oreal S.A.
    Inventors: Isabelle Mouyna, Cecile Clavaud, Christiane Bouchier, Jean-Paul Latge, Lionel Breton
  • Publication number: 20140193349
    Abstract: The invention relates to the nontherapeutic cosmetic use of at least one cannabinoid compound chosen from the compounds corresponding to general formula (I): and also the geometric isomers and optical isomers thereof, the cosmetically acceptable acid or base salts thereof, and the hydrates thereof; in which compounds of formula (I): R1 represents a hydrogen atom or a C1-C30 alkyl group; it being possible for said alkyl group to be optionally substituted with a hydroxyl (OH) group; R2 represents a halogen atom or a group chosen from hydroxyl, thiol (SH), and amino optionally substituted with one or two C1-C6 alkyl groups; R3 and R4 form, together with the carbon atom which bears them, an oxo group or else R3 and R4 represent a hydrogen atom; R5 represents a hydrogen atom or a C1-C6 alkyl group; X represents a heteroatom chosen from oxygen and sulfur atoms and the divalent group —N(R6)—, with R6 representing a hydrogen atom or a C1-C6 alkyl group; represents a single or double bond; n is 1, 2 or 3, prefe
    Type: Application
    Filed: August 3, 2012
    Publication date: July 10, 2014
    Applicant: L'OREAL
    Inventors: Michela Zuccolo, Roland Jourdain, Lionel Breton, Mauro Maccarrone
  • Patent number: 8377679
    Abstract: The present invention pertains to the use of probiotics for the preparation of a carrier for balancing the skin's immune function. In particular, the present invention pertains to the use of probiotic micro-organisms for balancing the skin's immune function under stress conditions, such as a exposure to ultraviolet radiation, specifically for enhancing the skin's immune activity and reducing the tendency to develop allergic reactions under such conditions.
    Type: Grant
    Filed: August 7, 2009
    Date of Patent: February 19, 2013
    Assignee: Nestec S.A.
    Inventors: Markus Baur, Lionel Breton, Francois Couzy, Audrey Gueniche
  • Publication number: 20120231099
    Abstract: Cosmetic use of an effective amount of a lysate of at least one microorganism of the genus Bifidobacterium species and/or one of its fractions in treating and/or preventing dryness and/or associated disorders of a keratinous substance.
    Type: Application
    Filed: May 15, 2012
    Publication date: September 13, 2012
    Applicant: L'OREAL
    Inventors: Isabelle CASTIEL, Lionel BRETON, Audrey GUENICHE