Patents by Inventor Lionel Wightman

Lionel Wightman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of mitochondrially targeted antioxidant in treatment and prevention of drug-induced liver disease
    Publication number: 20070161609
    Abstract: The present invention relates to the method of treatment or prophylaxis of patients with drug-induced liver diseases which comprises administering to the patient in need thereof a therapeutically effective amount of a mitochondrially targeted antioxidant compound e.g. derivatives of vitamin E, coenzyme Q10 or a glutathione peroxidase mimetic. The present invention also relates to pharmaceutical compositions containing the antioxidant(s) intended for such use.
    Type: Application
    Filed: January 10, 2006
    Publication date: July 12, 2007
    Inventors: Charles Buck, Helmut Denk, Eleonore Frohlich, Birgit Gutmann, Peter Hecht, Ivica Kvietikova, Marcus Otte, Gottfried Schatz, Cornelia Stumptner, Lionel Wightman, Kurt Zatloukal
  • Transferrin polycation/DNA complexes for the systemic treatment of tumor diseases with cytotoxic proteins
    Publication number: 20020137670
    Abstract: Complex of DNA, containing one or more DNA molecules coding for one or more therapeutically active proteins with a cytotoxic activity, and a polycation conjugated with transferrin with a zeta potential of ≦+15 mV. The complex, in which a high transferrin content screens the positive charge, produces a targeted transportation of the therapeutic DNA to the tumors in the systemic treatment of tumor diseases.
    Type: Application
    Filed: October 3, 2001
    Publication date: September 26, 2002
    Applicant: Boehringer Ingelheim International GmbH.
    Inventors: Ralf Kircheis, Ernst Wagner, Lionel Wightman, Elinborg Ostermann