Abstract: RNA molecules comprising a guide sequence portion having 17-20 nucleotides in the sequence of 17-20 contiguous nucleotides set forth in any one of SEQ ID NOs: 1-3010 and compositions, methods, and uses thereof.

Abstract: The present invention provides a non-naturally occurring composition comprising a CRISPR nuclease comprising a sequence having at least 95% identity to the amino acid sequence of SEQ ID NO: 3 or a nucleic acid molecule comprising a sequence encoding the CRISPR nuclease.

Abstract: The present invention relates to compositions and methods for increasing the rate of site specific insertion of a donor DNA sequence to the genome. More specifically, the method introduces a donor DNA template containing at least one transcription factor binding site to a cell in order to favor specific insertion of a donor template sequence at a target site by homology directed repair (HDR).

Abstract: Various embodiments for implementing a multimedia conference session utilizing a software defined networking (SDN) architecture are described. Various embodiments include an SDN media controller (SDNMC) that initially receives a request to establish a multimedia conferencing session between a plurality of endpoints. Based on the request, the SDNMC allocates at least one virtual media address for the multimedia conferencing session and creates a stream table based on the at least one virtual media address. After processing the request, the SDNMC transmits one or more SDN commands that includes the stream table to the SDN controller. The SDN controller receives the SDN commands at a northbound interface and sends one or more SDN instructions to one or more SDN devices at a southbound interface. The SDN devices update their routing information in order to relay media traffic corresponding to the virtual media address directly between the endpoints.

Abstract: Various embodiments for implementing a multimedia conference session utilizing a software defined networking (SDN) architecture are described. Various embodiments include an SDN media controller (SDNMC) that initially receives a request to establish a multimedia conferencing session between a plurality of endpoints. Based on the request, the SDNMC allocates at least one virtual media address for the multimedia conferencing session and creates a stream table based on the at least one virtual media address. After processing the request, the SDNMC transmits one or more SDN commands that includes the stream table to the SDN controller. The SDN controller receives the SDN commands at a northbound interface and sends one or more SDN instructions to one or more SDN devices at a southbound interface. The SDN devices update their routing information in order to relay media traffic corresponding to the virtual media address directly between the endpoints.

Abstract: Various embodiments for implementing a multimedia conference session utilizing a software defined networking (SDN) architecture are described. Various embodiments include a SDN media controller (SDNMC) that initially receives a request to establish a multimedia conferencing session between a plurality of endpoints. Based on the request, the SDNMC allocates at least one virtual media address for the multimedia conferencing session and creates a stream table based on the at least one virtual media address. After processing the request, the SDNMC transmits one or more SDN commands that includes the stream table to the SDN controller. The SDN controller receives the SDN commands at a northbound interface and sends one or more SDN instructions to one or more SDN devices at a southbound interface. The SDN devices update their routing information in order to relay media traffic corresponding to the virtual media address directly between the endpoints.

Abstract: Various embodiments for implementing a multimedia conference session utilizing a software defined networking (SDN) architecture are described. Various embodiments include a SDN media controller (SDNMC) that initially receives a request to establish a multimedia conferencing session between a plurality of endpoints. Based on the request, the SDNMC allocates at least one virtual media address for the multimedia conferencing session and creates a stream table based on the at least one virtual media address. After processing the request, the SDNMC transmits one or more SDN commands that includes the stream table to the SDN controller. The SDN controller receives the SDN commands at a northbound interface and sends one or more SDN instructions to one or more SDN devices at a southbound interface. The SDN devices update their routing information in order to relay media traffic corresponding to the virtual media address directly between the endpoints.