Abstract: A medical system includes an ultrasound probe, a treatment probe, and processor. Ultrasound probe and treatment probe are configured for insertion into an organ, to, respectively, image a volume of the organ, and introduce a treatment device therein. The probes respectively include first sensor configured to output first signals indicative of first positions of an ultrasound transducer array of the probe inside the organ, and second sensor configured to output second signals indicative of second positions of the treatment device inside the organ. The processor is configured to receive tags added to ultrasound images acquired using the ultrasound probe and mark tissue regions of the organ, register first positions of ultrasound transducer array and second positions of treatment device with one another, using registration, track relative position between treatment device and tagged tissue regions, and (iv) alert user when treatment device is within predefined proximity to tagged tissue region.

Abstract: In one embodiment, a medical system includes respective electrodes for application to a body of a subject and to output a set of respective activation signals in response to electrical activity of a heart of the subject captured over a sequence of heartbeat intervals, and a processor to classify a first heartbeat interval of the set of activation signals as a first morphological template, compute a measure of similarity between a second heartbeat interval of the set of activation signals and the first morphological template, group the second heartbeat interval of the set of activation signals in a first morphological group with the first morphological template responsively to the measure exceeding a predefined threshold, and classify the second heartbeat interval of the set of activation signals as a second morphological template responsively to the measure not exceeding the predefined threshold, and repeat the above, mutatis mutandis, for subsequent heartbeat intervals.

Abstract: In one exemplary mode, a medical system includes an ultrasound probe configured to captured ultrasonic images of at least part of a body part of a living subject, a display, and a processor configured to render to the display respective representations of respective electro-anatomical data subsets superimposed over respective ones of the ultrasonic images.

Abstract: In one embodiment, a medical system includes respective electrodes for application to a body of a subject and to output a set of respective activation signals in response to electrical activity of a heart of the subject captured over a sequence of heartbeat intervals, and a processor to classify a first heartbeat interval of the set of activation signals as a first morphological template, compute a measure of similarity between a second heartbeat interval of the set of activation signals and the first morphological template, group the second heartbeat interval of the set of activation signals in a first morphological group with the first morphological template responsively to the measure exceeding a predefined threshold, and classify the second heartbeat interval of the set of activation signals as a second morphological template responsively to the measure not exceeding the predefined threshold, and repeat the above, mutatis mutandis, for subsequent heartbeat intervals.

Abstract: A cosmetic method of directionally tightening human skin tissue includes providing an ablative laser source and a non-ablative laser source, then using the ablative laser source to form one or more overlapping circular shaped microchannels in the skin tissue; the overlapping microchannels formed have a longitudinal dimension larger than their cross dimension; then, using the non-ablative laser source to weld the microchannels, whereby the welding causes the skin tissue to tighten.

Abstract: In one embodiment, a medical system includes a catheter configured to be inserted into a cavity of a body of a living subject, and including an inflatable balloon comprising electrodes, the inflatable balloon being configured to press the electrodes against tissue of the cavity and at least partially block blood flow in the cavity, an ultrasound probe configured to provide velocity measurements of the blood flow in the cavity over time, a processor configured to assess a quality of contact of the electrodes with the tissue responsively to at least one of the velocity measurements of the blood flow in the cavity, and output an indication of the quality of contact to an output device, and a power supply configured to provide at least one electrical signal to the electrodes in order to ablate the tissue of the cavity.

Abstract: In one embodiment a system includes a ultrasound probe to capture 2D ultrasonic images of a body part of a living subject, a process to generate a 3D anatomical map of the body part, the 3D anatomical map and the 2D ultrasonic images being registered with a 3D coordinate space, add a 3D indication of an anatomical structure to the 3D anatomical map, render to a display the 3D anatomical map including the 3D indication of the anatomical structure, and render to the display a given one of the 2D ultrasonic images with a 2D indication of the anatomical structure on the given 2D ultrasonic image responsively to the 3D indication of the anatomical structure.

Abstract: In one embodiment, a medical system includes a catheter configured to be inserted into a chamber of a heart of a living subject, and including multiple electrodes configured to capture electrical activity from electrical activation signals propagating in tissue of the chamber, a display, and processing circuitry configured to automatically select bipolar signals to be captured into an electro-anatomical map from respective electrode pairs of the multiple electrodes responsively to an alignment of the respective electrode pairs with a direction of propagation of the electrical activation signals, and render the electro-anatomical map to the display.

Abstract: A method includes, based on respective signals acquired by a plurality of electrodes on an anatomical surface of a heart, computing respective local activation times (LATs) at respective locations of the electrodes. The method further includes, based on the LATs, computing respective directions of electrical propagation at the locations. The method further includes selecting pairs of adjacent ones of the electrodes such that, for each of the pairs, a vector joining the pair is aligned, to within a predefined threshold degree of alignment, with the direction of electrical propagation at the location of one of the electrodes belonging to the pair. The method further includes associating respective bipolar voltages measured by the pairs of electrodes with a digital model of the anatomical surface. Other examples are also described.

Abstract: A method includes obtaining multiple local activation times (LATs) at different respective measurement locations on an anatomical surface of a heart. The method further includes computing respective directions of electrical propagation at one or more sampling locations on the anatomical surface, by, for each sampling location, selecting a respective subset of the measurement locations for the sampling location, constructing a set of vectors, each of at least some of the vectors including, for a different respective measurement location in the subset, three position values derived from respective position coordinates of the measurement location and an LAT value derived from the LAT at the measurement location, and computing the direction of electrical propagation at the sampling location based on a Principal Component Analysis (PCA) of a 4×4 covariance matrix for the set of vectors. The method further includes indicating the directions of electrical propagation on a display.

Abstract: A cosmetic method of directionally tightening human skin tissue includes providing an ablative laser source and a non-ablative laser source, then using the ablative laser source to form one or more overlapping circular shaped microchannels in the skin tissue; the overlapping microchannels formed have a longitudinal dimension larger than their cross dimension; then, using the non-ablative laser source to weld the microchannels, whereby the welding causes the skin tissue to tighten.

Abstract: In one embodiment, a medical system includes respective electrodes for application to a body of a subject and to output a set of respective activation signals in response to electrical activity of a heart of the subject captured over a sequence of heartbeat intervals, and a processor to classify a first heartbeat interval of the set of activation signals as a first morphological template, compute a measure of similarity between a second heartbeat interval of the set of activation signals and the first morphological template, group the second heartbeat interval of the set of activation signals in a first morphological group with the first morphological template responsively to the measure exceeding a predefined threshold, and classify the second heartbeat interval of the set of activation signals as a second morphological template responsively to the measure not exceeding the predefined threshold, and repeat the above, mutatis mutandis, for subsequent heartbeat intervals.

Abstract: A cosmetic method of directionally tightening human skin tissue includes providing an ablative laser source and a non-ablative laser source, then using the ablative laser source to form one or more overlapping circular shaped microchannels in the skin tissue; the overlapping microchannels formed have a longitudinal dimension larger than their cross dimension; then, using the non-ablative laser source to weld the microchannels, whereby the welding causes the skin tissue to tighten.

Abstract: A cosmetic method for treating a human body to reduce hyperhidrosis includes applying laser light energy to one or more portions of the human body in which the laser light energy is one or more of: about 450 nm, about 930 nm, about 970 nm and about 1060 nm. An apparatus for accomplishing this method includes a source of laser light energy and a controller for controlling the laser light source to apply laser light energy to target and disrupt sweat glands in the human body.

Abstract: A cosmetic method of directionally tightening human skin tissue includes providing an ablative laser source and a non-ablative laser source, then using the ablative laser source to form one or more overlapping circular shaped microchannels in the skin tissue; the overlapping microchannels formed have a longitudinal dimension larger than their cross dimension; then, using the non-ablative laser source to weld the microchannels, whereby the welding causes the skin tissue to tighten.

Abstract: The present invention identifies genotypes associated with resistance to extrapyramidal symptoms induced by antipsychotic drugs. The present invention further identifies genotypes associated with predisposition to the onset or aggravation of extrapyramidal symptoms induced by antipsychotic drugs and use thereof for assessment of patient populations. Specifically, the present invention relates to particular polymorphisms in the RGS2 gene that are associated with resistance or susceptibility to drug-induced extrapyramidal symptoms.

Abstract: The present invention relates to genotypes associated with resistance to antipsychotic-induced parkinsonism and other extrapyramidal symptoms induced by antipsychotics, and use of said genotypes for assessment of patient populations. The methods and kits of the invention are based on identifying in a sample obtained from a subject, specific SNPs in the ZFPM2 and RGS2 genes.

Abstract: The present invention identifies genotypes associated with resistance to extrapyramidal symptoms induced by antipsychotic drugs. The present invention further identifies genotypes associated with predisposition to the onset or aggravation of extrapyramidal symptoms induced by antipsychotic drugs and use thereof for assessment of patient populations. Specifically, the present invention relates to particular polymorphisms in the RGS2 gene that are associated with resistance or susceptibility to drug-induced extrapyramidal symptoms.

Abstract: The present invention identifies genotypes associated with resistance to extrapyramidal symptoms induced by antipsychotic drugs. The present invention further identifies genotypes associated with predisposition to the onset or aggravation of extrapyramidal symptoms induced by antipsychotic drugs and use thereof for assessment of patient populations. Specifically, the present invention relates to particular polymorphisms in the RGS2 gene that are associated with resistance or susceptibility to drug-induced extrapyramidal symptoms.