Abstract: Embodiments of the present invention provide Dermal Micro Organs (DMOs), methods and apparatuses for producing the same. Some embodiments of the invention provide a DMO including a plurality of dermal components, which substantially retain the micro-architecture and three dimensional structure of the dermal tissue from which they are derived, having dimensions selected so as to allow passive diffusion of adequate nutrients and gases to cells of the DMO and diffusion of cellular waste out of the cells so as to minimize cellular toxicity and concomitant death due to insufficient nutrition and accumulation of waste in the DMO. Some embodiments of the invention provide methods and apparatuses for harvesting the DMO. An apparatus for harvesting the DMO may include, according to some exemplary embodiments, a support configuration to support a skin-related tissue structure from which the DMO is to be harvested, and a cutting tool able to separate the DMO from the skin-related tissue structure.

Abstract: Device for treating pathological conditions of skin surfaces, which comprises a main component that includes a body and a contact layer superimposed to one another, wherein the body is porous to provide storage capacity for liquid medicament fed to it and permeable for transmitting the medicament to the contact layer by compression or capillarity or both. The contact layer is also porous for transmitting the medicament received from the body to the skin surface being treated and has a mildly or strongly abrasive outer surface for removing damaged surface skin tissue. The device also comprises a delivery apparatus for feeding liquid medicament to the body of the main component and, an optional storage container for the liquid medicament.

Abstract: Occlusive dressing system, which comprises an endless, elongated, flexible, adhesive barrier, adapted to be arranged in a closed configuration, whereby to bound and define a surface area, and an impermeable sealing film adapted to overlie said surface area and to isolate it from the environment, when superimposed to said barrier arranged in said configuration, said barrier forming a gas-tight seal with said sealing film when the two are applied to and pressed against one another. A spreading mechanism that alows a single person to spread the sealing film over the occluding barrier and to detach the film from the main roll and ports (inlet and outlet) that can be placed across the barrier or the occluding film.

Abstract: A device, system and method for enhancing the functionality and efficiency of a chemical and/or enzymatic debriding agent with a physical debriding mechanism. The debriding agent alone and the physical mechanism alone are each capable of at least some debriding activity separately, without being used in the combination. In combination, however, they are more effective, such that the debriding efficacy is increased for the combination. Preferably, the physical debriding mechanism comprises an ultrasound source.

Abstract: A micro-organ structure comprising at least two micro-organ portions formed from a tissue, in which said at least two micro-organs are linked one to the other by means of a junction formed from said tissue of which the micro-organs were formed therefrom.

Abstract: Apparatus suitable for use in the prevention and treatment of burn induced compartment syndrome facilitates the rapid and efficient deployment of enzymatic compositions to the affected limb or limbs of a burn victim suffering from a circumferential burn. The apparatus includes a flexible, water-impermeable generally cylindrical covering layer. The covering layer has an inner surface facing the limb and an outer surface. The covering layer has a proximal sealable open end through which the burned limb is inserted and a distal closed end. An enzymatic escharotomy agent is contained within the covering layer. The covering layer retains the enzymatic escharotomy agent in close proximity to the burned limb, and the apparatus is enclosed within a sterile sealed package evacuated from moisture.

Abstract: Device for treating pathological conditions of skin surfaces, which comprises a main component that includes a body and a contact layer superimposed to one another, wherein the body is porous to provide storage capacity for liquid medicament fed to it and permeable for transmitting the medicament to the contact layer by compression or capillarity or both. The contact layer is also porous for transmitting the medicament received from the body to the skin surface being treated and has a mildly or strongly abrasive outer surface for removing damaged surface skin tissue. The device also comprises a delivery apparatus for feeding liquid medicament to the body of the main component and, an optional storage container for the liquid medicament.

Abstract: Embodiments of the present invention provide Dermal Micro Organs (DMOs), methods and apparatuses for producing the same. Some embodiments of the invention provide a DMO including a plurality of dermal components, which substantially retain the micro-architecture and three dimensional structure of the dermal tissue from which they are derived, having dimensions selected so as to allow passive diffusion of adequate nutrients and gases to cells of the DMO and diffusion of cellular waste out of the cells so as to minimize cellular toxicity and concomitant death due to insufficient nutrition and accumulation of waste in the DMO. Some embodiments of the invention provide methods and apparatuses for harvesting the DMO. An apparatus for harvesting the DMO may include, according to some exemplary embodiments, a support configuration to support a skin-related tissue structure from which the DMO is to be harvested, and a cutting tool able to separate the DMO from the skin-related tissue structure.

Abstract: Method of holding in place a transcutaneous implant by applying an adhesive in liquid form to the implant and the area of the patient's skin about the needle and allowing the adhesive to set. The implant is constituted by an infusion needle, a catheter or any transcutaneous implant. Whenever the adhesive is in liquid form, it has such a surface tension that it will flow along the implant and the skin to reach a terminal point, which is the point at which the implant is inserted. The adhesive is applied in liquid form and flows along the implant and the skin to reach the point at which the implant is inserted, and then allowed to set to hold the implant in place.

Abstract: Pad for the treatment of inflammatory afflictions, which comprises an absorbing matrix, a medicament that is a hypertonic substance such as inorganic salt solutions, and a functional backing for directing and limiting the activity of the medicament to the desired body surface. The pad may further comprise binding means for maintaining it in place and in engagement with the desired body surface. The absorbing matrix and the functional backing may be structurally connected or separate. The absorbing matrix may be made of cotton, lignin cellulose or synthetic absorbing materials.

Abstract: A device, system and method for enhancing the functionality and efficiency of a chemical and/or enzymatic debriding agent with a physical debriding mechanism. The debriding agent alone and the physical mechanism alone are each capable of at least some debriding activity separately, without being used in the combination. In combination, however, they are more effective, such that the debriding efficacy is increased for the combination. Preferably, the physical debriding mechanism comprises an ultrasound source.

Abstract: Disclosure relates to a unit dose debriding matrix carrier, comprising a housing containing lyophilized or otherwise dried debriding agent, the housing being made of porous material so as to allow passage of the debriding agent therethrough when a liquid is applied thereto, the carrier further having a polygonal shape such that a plurality of identical carriers can be placed around it, to fill a wound area. This application also relates to a placing device for a unit dose debriding matrix carrier, comprising elastic holding means to hold the matrix in place within the device and to release the carrier when a light pressure is applied on the device, and a unit dose powder/vehicle-carrier-gel mixing and placing device comprising unit dose powder and vehicle containers and means for joining said containers and mixing the countenance aspeticly and extracting the mixture onto the wound.

Abstract: Mechanically actuated dermatome comprising a cutting blade, a hollow handle substantially perpendicular to the plane of the cutting blade and a motor housed in the hollow handle with its shaft substantially perpendicular to the plane of the cutting blade. The cutting blade is enclosed in a housing which has a lowermost surface that rides on the skin during treatment, the lower surface being essentially parallel to the plane of the cutting part of the blade and the handle is substantially perpendicular to it and directed upwards when the dermatome rests on the lowermost surface of the blade housing. The lowermost surface that rides on the skin during treatment is smooth, without any protrusion that may interfere with its movement in any direction with respect to the skin.

Abstract: The present invention generally relates to a skin graft preparation device, or mesher. This device is designed to incise and "mesh" a piece of skin, usually prior to grafting to allow it to expand and cover an area larger than its donor site area. More specifically, the invention relates to an adjustable mesher device wherein the mesher has an adjustable meshing drum (roller) or drums useful for the meshing of the entire range of meshing ratios, thus eliminating the need to keep various meshing devices. Another embodiment of the mesher has two consecutive meshing drums. A further embodiment of the mesher has a rotatable common holder allowing selection from a number of meshing drums. These meshers can mesh skin in both powered and manual modes of operation and may be used with most existing graft carriers or may be used without any carrier. The present invention further relates to a system for using the mesher.

Abstract: A fluid drain for wounds includes a tube having one end insertable under the patient's skin into the wound, with the opposite end of the tube extending externally of the patient's skin; and a valve assembly at the opposite end of the tube. The valve assembly includes a first port for connection to a vacuum source, a second port connected to the opposite end of the tube, a third port for outletting the drained fluid into a container, a first one-way valve permitting the fluid to flow freely therethrough only from the second port to the first port, and a second one-way valve permitting the fluid to flow freely therethrough only from the first port to the third port.

Abstract: A vaccum device includes a cylinder, a plunger receivable through the open end of the cylinder and having a piston movable within the cylinder to define a suction chamber; and indicia carried by the cylinder cooperable with a reference on the plunger for providing a visual indication of the suction in the suction chamber. The indicia is in the form of a curve representing the variation of pressure in the suction chamber with the volume of the chamber as indicated by a reference on the piston.

Abstract: A surgical tissue separation system comprises a handle formed with a bore, a metal blade mounted to one end of the handle and supplied with electricity, and a suction tube connected to the opposite end of the handle by a connector which includes a first section for connection to the suction tube, a second section for connection to a vacuum source for removing smoke and fumes produced by burnt tissue, and a third section for connection to an auxiliary vacuum tip for removing fluids.

Abstract: A balloon-type Tissue expander device is provided that has a main balloon portion for stretching tissue when implanted under the skin. The expander balloon includes an inflation conduit and a separate drain tube connected thereto serving to drain fluid accumulating around the balloon away from the implant site. Also an irrigation tube can be included with the drain tube. Finally a pressure transducer is provided to measure pressure within the balloon.

Abstract: A self-locking pin device comprises a pin formed with enlargement in the region of its distal end; a tube received over the pin and having a diameter smaller than the enlargement, the tube being axially split at both its distal and proximal ends; and a collar received between the proximal ends of the pin and tube such that moving either the pin or tube splays the distal end of the tube about its axial split, and moving either the collar or the tube splays the proximal end of the tube along its axial split.

Abstract: A dermatome particularly useful for skin-grafting purposes comprises a guard for controlling the cutting depth, and an adjusting mechanism for effecting an angular displacement between the guard and the cutting depth, the guard extending the complete length of the cutting edge of the blade and being rounded at its opposite end enabling the full blade length to be used. The dermatome may be constructed with the guard, or the guard may be included in an accessory for attachment to the dermatome.