Abstract: The invention provides various novel compositions of berberine in combination with pharmacologically active organic acids, and related methods of their use in treating various diseases or disorders. The invention further provides various novel compounds prepared from berberine and pharmacologically active organic acids and prepared from ursodeoxycholic acid and pharmacologically active organic bases, and pharmaceutical compositions thereof, and methods of their preparation and therapeutic use in treating and/or preventing various diseases or disorders.

Abstract: A piston limiting structure, including: a cylinder, a piston, and a flange provided with a limiting piece, the cylinder has a piston hole perpendicular to an axial direction of the cylinder and penetrating through the cylinder, and a projection of the piston hole in a penetrating direction is circular. The piston is disposed in the piston hole in a form-fit manner and is slid in the piston hole in a reciprocating manner. A side wall of the piston is provided with a thrust groove, a bottom surface of the thrust groove forms a thrust surface on the side wall of the piston, and the thrust groove does not penetrate through two ends of the side wall of the piston along an axial length of the piston. The limiting piece abuts against the thrust surface.

Abstract: The disclosure relates to bit-interleaved coded modulation with iterative decoding. In some implementations, a receiver comprises: a first memory including multiple first sub-memories; a decoder configured to perform first operations comprising: calculating, first extrinsic information of multiple code bits associated with multiple received symbols; and a demapper configured to perform second operations comprising: calculating soft decision information of the code bits; calculating, based on the soft decision information and the first extrinsic information, second extrinsic information of the code bits; and writing the second extrinsic information of the code bits into the first memory such that, for each received symbol, each sub-memory of the first sub-memories respectively stores the second extrinsic information associated with a respective one of the code bits corresponding to the received symbol.

Abstract: The invention provides novel pharmaceutical compositions of berberine or a derivative or analog of berberine, or a salt thereof, in combination with one or more omega-3 fatty acids or esters thereof, and methods of their use in treating inflammatory bowel disease.

Abstract: An application of fengycin family lipopeptides in pest control is provided, and Fengycin family lipopeptides are used for pest control, with especially strong killing effects on Homoptera and Coleoptera pests. A method is provided for treating seeds with fengycin to protect seeds and plant organs formed later from pests, so as to protect seeds from pests by coating the fengycin family lipopeptides on the surface of seeds.

Abstract: A process for treating aged oil by electron beam irradiation is disclosed, comprising the following steps: step 1, homogenizing the aged oil and then feeding the aged oil into a distributor; step 2, forming a liquid layer having a certain thickness on the distributor; step 3, installing and debugging an electron beam irradiation device on the distributor; step 4, installing and debugging a phased-array microwave emitter on the distributor after installing and debugging the electron beam irradiation device; step 5, turning on the electron beam irradiation device and the phased-array microwave emitter; and step 6, dividing the treated aged oil and then allowing the aged oil after dividing to enter an oil pool and a water pool for standing. Oil flows out from an upper layer of the oil pool, a lower layer of the oil pool flows back to an aged oil storage pool.

Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.

Abstract: Provided in the present invention are the maintenance of the programmed chronic liver injury of FAH gene-deficient animals and an application thereof in the preparation of heterologous liver models. The present invention discloses a programmed NTBC controlling (NTBCP) scheme with a fixed cycle period, the scheme enabling animal models to survive for a long time in a state of chronic liver injury, and being capable of achieving a high heterologous replacement rate after a heterologous hepatocyte transplantation is performed.

Abstract: The present disclosure discloses a medical material and a product and preparation method thereof. The medical material comprises a ferroelectric polymer, and optionally further comprises an inorganic ferroelectric particle. The composite membrane is prepared by experiencing at least one of annealing treatment, corona poling treatment, acid treatment, and ultrasonic treatment, and the acid treatment is conducted after the annealing treatment. The present disclosure further relates to a method for treating a composite membrane to regulate an antibacterial activity.

Abstract: The disclosure generally describes methods of preventing or treating ophthalmic diseases or conditions in a mammalian subject, such as diabetic retinopathy, cataracts, retinitis pigmentosa, glaucoma, macular degeneration, choroidal neovascularization, retinal degeneration, and oxygen-induced retinopathy. The methods comprise administering an effective amount of an aromatic-cationic peptide to subjects in need thereof.

Abstract: An on-line measurement-error correction device and method for the inner profile of a special-shaped shell, including a fixing device. A vertical moving device is fixed at the top of the fixing device and connected with a horizontal moving device connected with a distance monitoring device, which is movable vertically and horizontally under the drive of the vertical and horizontal moving devices. The distance monitoring device includes a displacement monitoring element fixedly arranged on a fixing support hinged with an electric push rod configured to displace to drive the displacement monitoring element to deflect so as to change a monitoring direction. The displacement monitoring element is driven to deflect by the electric push rod of the distance monitoring device to change a monitoring direction, and a distance between each longitudinal section surface point on the inner surface of the special-shaped shell and the displacement monitoring element can be gradually measured.

Abstract: Described herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, such as cancer, metabolic and blood disorders. Compounds of Formula (I) have the following structure of Formula (I).

Abstract: The invention discloses a coordination type zirconium phosphotungstate catalyst and its application in catalytic hydrogenation of furfural, belonging to the field of heterogeneous catalysis. The zirconium phosphotungstate catalyst prepared by the invention not only has good catalytic effect on the conversion of furfural to furfuryl alcohol, but also has mild reaction conditions. The yield of solid line furfuryl alcohol can be 98% if it can be reacted for 1 h at 120 ° C., and the amount of catalyst is less, which greatly reduces the energy consumption in the prior art. In addition, the zirconium phosphotungstate prepared by the invention is easy to separate, has good stability for catalyzing the hydrogenation of furfural to furfuryl alcohol, and is a new, efficient and green catalyst.

Abstract: An oral capsule formulation of a PARP inhibitor and a preparation method. The oral capsule formulation comprises a solid dispersion powder of an active ingredient 5-fluoro-1-(4-fluoro-3-(4-(pyrimidin-2-yl)piperazine-1-carbonyl)benzyl)quinazoline-2,4(1H,3H)-dione, a filler, a disintegrant, a glidant, and a lubricant, wherein less than 10 wt. % of the active ingredient in the solid dispersion powder is in a crystalline form. The defects of the fluidity, hygroscopicity and cohesiveness of the solid dispersion powder which result in the difficulty of production scale up of capsule formulation are addressed, and thus commercial scale production can be achieved, and the prepared capsule exhibits proper dissolution rate, excellent storage stability, meanwhile with a reasonable production cost.

Abstract: Described herein are compounds and compositions for electrolytes based on bidentate and monodentate fluorinated alcohols. Also described are batteries that include the compounds and electrolytes described herein.

Abstract: An information display method and apparatus, and a computer-readable storage medium and an electronic device. The method includes: determining a target font category to be written in response to an operation of a user on a display device page; determining a target font conversion model corresponding to the target font category in a model library, wherein the model library including font conversion models corresponding to a plurality of font categories; in response to a writing operation of the user on the display device page, determining a standard word corresponding to the writing operation according to a writing trajectory of the writing operation, and generating an initial bitmap corresponding to the standard word; and converting the initial bitmap of the standard word into a target bitmap corresponding to the target font category using the target font conversion model and displaying the target bitmap on the display device page.

Abstract: A method comprises obtaining a test specification document of a user, wherein the test specification document comprises a test scheme based on a natural language; recommending, to the user and based on a first test step in the test scheme, a test interface set comprising a plurality of test interfaces for implementing a second test step, performing, by the user, a selection operation on the test interfaces in the test interface set; and generating, based on the selection operation, one or more test cases.

Abstract: An electric generator includes a turbine wheel configured to receive process gas and rotate in response to expansion of the process gas flowing into an inlet of the turbine wheel. A rotor is coupled to the turbine wheel and can rotate with the turbine wheel in a stator. The electric generator generates a current upon rotation of the rotor within the stator. A power electronics system is electrically connected to an electrical output of the electric generator and receives alternating current from the electric generator. The electric generator includes a brake resistor assembly having an impedance that matches an impedance of the electric generator. A contactor is electrically connected the electrical output of the electric generator and is configured to connect the electric generator to the brake resistor assembly based on a fault condition.

Abstract: Disclosed are a method for switching a theme of an application and an electronic device, which belong to the field of electronic technologies. The electronic device receives a theme switching request for a first application in the electronic device. The theme switching request includes an indication for a target theme. In response to the theme switching request, the electronic device switches a theme of the first application to the target theme, and switches a theme of a second application having an association relationship with the first application in the electronic device to the target theme.

Abstract: A first user equipment (UE) is configured to establish a first tethered connection with a second UE 104 and a second tethered connection with at least a third UE. The first UE identifies a plurality of network slices provided by a network. The first UE selects at least a first network slice for the second UE and selects at least a second network slice for the at least third UE. The first UE wirelessly communicates data for the second UE over the at least first network slice using a first upstream link. The first UE wirelessly communicates data for the at least third UE over the at least second network slice using a second upstream link. The first upstream link and the second upstream link are concurrently maintained.