Abstract: A method for evaluating an aging state of a silicone rubber composite insulator includes: step 1: collecting samples from the silicone rubber composite insulator, and subjecting samples in a surface layer and a center layer successively to hydrophobicity, flexing resistance, hardness, color, and absorbance tests; step 2: determining relevant data of the samples in a natural evolution process according to the tests in step 1; step 3: subjecting the samples to thermo-oxidative aging; and after the thermo-oxidative aging is completed, subjecting the samples to a hardness test of artificial accelerated evolution, and calculating position coordinates (F1, F2) of the samples in an aging space; and step 4: classifying the samples in advance and solving an aging state centroid of each classified population, calculating a minimum aging distance based on the position coordinates in step 3, and evaluating the aging state of the silicone rubber composite insulator.

Abstract: The present invention belongs to the field of pharmaceutical chemistry, and relates to a substituted pyrazine compound, a pharmaceutical composition comprising same, and the use thereof. In particular, the present invention relates to a compound with the structure of formula (I), which exhibits a good SHP2 inhibiting activity, and can act as an efficient SHP2 inhibitor for preventing and/or treating SHP2-related diseases.