Patents by Inventor Liqiang ZHAO
Liqiang ZHAO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240390469Abstract: Disclosed are a targeted traditional Chinese medicine in-situ tumor vaccine, a preparation method thereof and an application thereof in resisting pancreatic cancer. In the invention, PLGA nanospheres are used to carry Lycium barbarum polysaccharide and Brusatol, and subjected to surface modification with a macrophage membrane and a c-RGD peptide. The invention can be targeted at a tumor site in vivo, so that the tumor undergoes immunogenic cell death and releases tumor antigens, and can also regulate immune cells at the same time, so as to remodel the tumor microenvironment, and achieve robust anti-pancreatic cancer effect. In the invention, the preparation method is simple, and the tumor vaccine is suitable for carrying a cancer therapeutic drug, especially a drug for treating pancreatic cancer.Type: ApplicationFiled: August 6, 2024Publication date: November 28, 2024Applicant: NANJING UNIVERSITY OF CHINESE MEDICINEInventors: Jinao DUAN, Jialun DUAN, Chunjie BAO, Liqiang ZHAO, Sheng GUO
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Publication number: 20230292803Abstract: Described herein is a sweetener composition useful for improving the taste and mouthfeel of food and beverage composition as well as a ready to drink or ready to mix beverage composition, such as a protein shake comprising the sweetener composition.Type: ApplicationFiled: January 20, 2023Publication date: September 21, 2023Inventors: Liqiang Zhao, Madhavi Ummadi
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Publication number: 20230098327Abstract: Described herein is an innovative composition that improves sleep quality. This composition includes two important systems: 1) a sleep-inducing system that is being used for the first time in food and beverage products; and 2) a unique stabilizer system that provides a robust rheology and greater stability than other stabilizers. The two systems can be incorporated, individually or in combination, into food and beverage products, including but not limited to protein shakes and powders. Together, they enable this composition to aid in relaxation and optimal sleep quality, better sensory taste experiences than current market products, longer shelf life and robust stability. This disclosure also addresses a relevant need in the art for a beverage composition that promotes calmness and reduces stress by using natural ingredients, more specifically made from milk casein.Type: ApplicationFiled: August 30, 2022Publication date: March 30, 2023Inventors: Madhavi Ummadi, Nishtha Lukhmana, Venkata Sarath Pamu, Liqiang Zhao, Kimberly Ann Swisher Lutze, Emily Elizabeth Hurt
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Patent number: 11319789Abstract: The present disclosure discloses a rotary downhole cavitation generator, including an upper connector, a lower connector, and a casing. Said casing is internally provided with a transmission shaft, an alignment bearing, a drive assembly, a thrust bearing, a rotating disk, a rectification cylinder, an inner sleeve, and an outer sleeve. Said transmission shaft is provided with a deep hole, a diversion hole radially communicating with said deep hole, and a diversion channel radially communicating with said deep hole. Said alignment bearing and said drive assembly are sleeved on an upper end of said transmission shaft, and said rotating disk, said inner sleeve, and said thrust bearing are sleeved on a lower end of said transmission shaft. Said rectification cylinder and said outer sleeve are mounted on an inner wall of said casing, and said upper connector and said lower connector are respectively connected to both ends of said casing.Type: GrantFiled: June 28, 2021Date of Patent: May 3, 2022Assignee: SOUTHWEST PETROLEUM UNIVERSITYInventors: Ruyi Gou, Weiyu Chen, Liqiang Zhao, Pingli Liu, Zhifeng Luo, Nanlin Zhang
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Publication number: 20220010665Abstract: The present disclosure discloses a rotary downhole cavitation generator, including an upper connector, a lower connector, and a casing. Said casing is internally provided with a transmission shaft, an alignment bearing, a drive assembly, a thrust bearing, a rotating disk, a rectification cylinder, an inner sleeve, and an outer sleeve. Said transmission shaft is provided with a deep hole, a diversion hole radially communicating with said deep hole, and a diversion channel radially communicating with said deep hole. Said alignment bearing and said drive assembly are sleeved on an upper end of said transmission shaft, and said rotating disk, said inner sleeve, and said thrust bearing are sleeved on a lower end of said transmission shaft. Said rectification cylinder and said outer sleeve are mounted on an inner wall of said casing, and said upper connector and said lower connector are respectively connected to both ends of said casing.Type: ApplicationFiled: June 28, 2021Publication date: January 13, 2022Inventors: Ruyi GOU, Weiyu CHEN, Liqiang ZHAO, Pingli LIU, Zhifeng LUO, Nanlin ZHANG
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Patent number: 11187250Abstract: The present invention relates to an automatic cleaning device for suction port of electric submersible pump. The pipe string joint is connected between the oil pipe and the electric submersible pump. A plurality of oil drain passage inlets, steel balls, return springs, sealing plugs and oil drain passage outlets are evenly distributed in circumferential direction of a boss. The upper end of the connecting pipe is connected with the outlet of the oil drain passage, and the lower end is connected with the nozzle. The retaining ring secures the connecting pipe on the housing of the electric submersible pump. A high-pressure fluid ejected from the nozzle directly acts on the suction port of the electric submersible pump. The present invention can automatically clean the suction port of the electric submersible pump by relying on the pressure difference between the outlet and the suction port of the electric submersible pump.Type: GrantFiled: June 11, 2021Date of Patent: November 30, 2021Assignee: SOUTHWEST PETROLEUM UNIVERSITYInventors: Ruyi Gou, Weiyu Chen, Liqiang Zhao, Pingli Liu, Zhifeng Luo, Juan Du
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Patent number: 11174425Abstract: The present invention relates to a carbonate reservoir filtration-loss self-reducing acid fracturing method.Type: GrantFiled: June 24, 2020Date of Patent: November 16, 2021Assignee: SOUTHWEST PETROLEUM UNIVERSITYInventors: Weiyu Chen, Liqiang Zhao, Zhifeng Luo, Juan Du, Pingli Liu, Nianyin Li, Kun Xu
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Publication number: 20210301835Abstract: The present invention relates to an automatic cleaning device for suction port of electric submersible pump. The pipe string joint is connected between the oil pipe and the electric submersible pump. A plurality of oil drain passage inlets, steel balls, return springs, sealing plugs and oil drain passage outlets are evenly distributed in circumferential direction of a boss. The upper end of the connecting pipe is connected with the outlet of the oil drain passage, and the lower end is connected with the nozzle. The retaining ring secures the connecting pipe on the housing of the electric submersible pump. A high-pressure fluid ejected from the nozzle directly acts on the suction port of the electric submersible pump. The present invention can automatically clean the suction port of the electric submersible pump by relying on the pressure difference between the outlet and the suction port of the electric submersible pump.Type: ApplicationFiled: June 11, 2021Publication date: September 30, 2021Applicant: SOUTHWEST PETROLEUM UNIVERSITYInventors: Ruyi Gou, Weiyu Chen, Liqiang Zhao, Pingli Liu, Zhifeng Luo, Juan Du
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Patent number: 10982131Abstract: Provided are a phase transition material fluid and a proppant formed therefrom, wherein the components for preparing the phase transition material fluid comprise in percentages by mass: a supramolecular building block 10 to 60 wt %, a supramolecular functional unit 20 to 50 wt %, a dispersant 0.1 to 2 wt %, an inorganic co-builder 0.1 to 1 wt %, an initiator 0.1 to 1 wt %, the balance being a solvent. The supramolecular building block comprises a melamine-based substance and/or a triazine-based substance; the supramolecular functional unit comprises a dicyclopentadiene resin; and the dispersant includes a hydroxyl-bearing polysaccharide substance and a surfactant. After the phase transition material fluid enters the reservoir, it may form a solid substance to prop the fracture under the action of supramolecular chemistry and physics.Type: GrantFiled: March 27, 2019Date of Patent: April 20, 2021Inventors: Shubao Hu, Yong Yang, Liqiang Zhao, Guohua Liu, Mengmeng Ning, Kun Xu, Juan Du, Ning Li, Lina Zhang, Yuanzhao Jia
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Publication number: 20210017445Abstract: The present invention relates to a carbonate reservoir filtration-loss self-reducing acid fracturing method.Type: ApplicationFiled: June 24, 2020Publication date: January 21, 2021Inventors: Weiyu CHEN, Liqiang ZHAO, Zhifeng LUO, Juan DU, Pingli LIU, Nianyin LI, Kun XU
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Patent number: 10833508Abstract: An active power distribution network multi-time scale coordinated optimization scheduling method and storage medium are provided. The method includes the following steps: performing long-time scale optimization scheduling of an active power distribution network; performing short-time scale rolling optimization scheduling on the basis of MPC of the active power distribution network according to an optimization result of the long-time scale optimization scheduling of the active power distribution network. By using a model prediction control method, taking the long-time scale optimization scheduling result as a reference, and performing short-time scale rolling correction, the optimization scheduling of the active power distribution network is achieved, thereby reducing unfavorable influences of prediction precision of a distributed power supply and a low-voltage load on the optimization scheduling.Type: GrantFiled: June 27, 2016Date of Patent: November 10, 2020Assignees: CHINA ELECTRIC POWER RESEARCH INSTITUTE COMPANY LIMITED, STATE GRID CORPORATION OF CHINA, NORTH CHINA ELECTRIC POWER UNIVERSITY, STATE GRID BEIJING ELECTRIC POWER COMPANY, STATE GRID TIANJIN ELECTRIC POWER COMPANYInventors: Xiaohui Wang, Tianjiao Pu, Lei Dong, Naishi Chen, Ye Li, Jiancheng Yu, Renle Huang, Xianjun Ge, Zhihong Li, Minghao Ai, Fumin Qu, Liqiang Zhao
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Publication number: 20200300082Abstract: The invention discloses a calculation method for dynamic fluid loss of acid-etched fracture considering wormhole propagation, which is applied to pad acid fracturing process, comprising the following steps: Step 1: dividing the construction time T of injecting acid fluid into artificial fracture into m time nodes at equal intervals, then the time step ?t=T/m and tn=n?t, where, n=0, 1, 2, 3, . . . , m, and to is the initial time; Step 2: calculating the fluid loss velocity vl(0) in the fracture at t0; Step 3: calculating the flowing pressure distribution P(n) in the fracture at tn; Step 4: calculating the width wa(n) of acid-etched fracture at tn; Step 5: calculating the wormhole propagation and the fluid loss velocity vl(n) at tn; Step 6: substituting the fluid loss velocity vl(n) into Step 3, and repeating Step 3 to Step 6 in turn until the end of acid fluid injection.Type: ApplicationFiled: June 11, 2020Publication date: September 24, 2020Applicants: SOUTHWEST PETROLEUM UNIVERSITY, PETROCHINA COMPANY LIMITEDInventors: Pingli Liu, Xiang Chen, Heng Xue, Honglan Zou, Liqiang Zhao, Nianyin Li, Daocheng Wang, Zhifeng Luo, Juan Du, Chong Liang, Mingyue Cui, Fei Liu, Changlin Zhou, Rong Zeng
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Publication number: 20200033933Abstract: An active power distribution network multi-time scale coordinated optimization scheduling method and storage medium are provided. The method includes the following steps: performing long-time scale optimization scheduling of an active power distribution network; performing short-time scale rolling optimization scheduling on the basis of MPC of the active power distribution network according to an optimization result of the long-time scale optimization scheduling of the active power distribution network. By using a model prediction control method, taking the long-time scale optimization scheduling result as a reference, and performing short-time scale rolling correction, the optimization scheduling of the active power distribution network is achieved, thereby reducing unfavorable influences of prediction precision of a distributed power supply and a low-voltage load on the optimization scheduling.Type: ApplicationFiled: June 27, 2016Publication date: January 30, 2020Inventors: Xiaohui Wang, Tianjiao Pu, Lei Dong, Naishi Chen, Ye Li, Jiancheng Yu, Renle Huang, Xianjun Ge, Zhihong Li, Minghao Ai, Fumin Qu, Liqiang Zhao
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Publication number: 20190300777Abstract: The present invention provides a phase transition material fluid and a proppant formed therefrom, wherein the components for preparing the phase transition material fluid comprise in percentages by mass: a supramolecular building block 10 to 60 wt %, a supramolecular functional unit 20 to 50 wt %, a dispersant 0.1 to 2 wt %, an inorganic co-builder 0.1 to 1 wt %, an initiator 0.1 to 1 wt %, the balance being a solvent. The supramolecular building block comprises a melamine-based substance and/or a triazine-based substance; the supramolecular functional unit comprises a dicyclopentadiene resin; and the dispersant includes a hydroxyl-bearing polysaccharide substance and a surfactant. After the phase transition material fluid enters the reservoir, it may form a solid substance to prop the fracture under the action of supramolecular chemistry and physics.Type: ApplicationFiled: March 27, 2019Publication date: October 3, 2019Applicant: PetroChina Company LimitedInventors: Shubao HU, Yong YANG, Liqiang ZHAO, Guohua LIU, Mengmeng NING, Kun XU, Juan DU, Ning LI, Lina ZHANG, Yuanzhao JIA
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Patent number: 10364388Abstract: The present invention discloses a phase change fracturing fluid system for phase change fracturing, including the following components in percentage by weight: 10%-40% of supramolecular construction unit, 0-40% of supramolecular function unit, 0.5%-2% of surfactant, 0-5% of inorganic salt, 0.5%-2% of oxidizing agent, 0-2% of cosolvent and the remaining of solvent. The supramolecular construction unit is melamine, triallyl isocyanurate, or a mixture thereof. The supramolecular function unit is vinyl acetate, acrylonitrile, or a mixture thereof. The solvent is methylbenzene, ethylbenzene, o-xylene, m-xylene or p-xylene. In the fracturing construction process, a conventional fracturing fluid is used for fracturing a formation first; the phase change fracturing fluid is then injected into the formation, or the phase change fracturing fluid and other fluids which cannot be subjected to phase change are injected into the formation together.Type: GrantFiled: September 20, 2016Date of Patent: July 30, 2019Assignee: SOUTHWEST PETROLEUM UNIVERSITYInventors: Liqiang Zhao, Yong Yang, Guangyan Du, Donghe Yu, Juan Du, Hang Che, Zhifeng Luo, Guohua Liu, Yuxin Pei, Nianyin Li, Pingli Liu, Kun Xu
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Patent number: 10301919Abstract: A phase-change hydraulic fracturing process, including the following steps: (1) injecting clean water or conventional fracturing fluid to a formation, so that the formation fractures; (2) placing non-phase-change liquid and phase-change liquid in different liquid mixing tanks and injecting into a shaft at the same time, an injection volume ratio of the non-phase-change liquid to the phase-change liquid is (0-0.7):(0.3-1); (3) injecting a displacement fluid into the shaft, so that the non-phase-change liquid and the phase-change liquid in the shaft completely enter a reservoir; (4) performing well shut-in and pressure-out for 30-200 min, so that solid-phase matters generated by the phase-change liquid are laid in the fracture; and (5) relieving pressure to finish the construction.Type: GrantFiled: September 20, 2016Date of Patent: May 28, 2019Assignee: SOUTHWEST PETROLEUM UNIVERSITYInventors: Liqiang Zhao, Yong Yang, Zhifeng Luo, Donghe Yu, Juan Du, Guohua Liu, Hang Che, Guangyan Du, Yuxin Pei, Nianyin Li, Pingli Liu, Kun Xu, Bingxiao Liu
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Publication number: 20190003294Abstract: The present invention discloses a phase-change hydraulic fracturing process, including the following steps: (1) injecting clean water or conventional fracturing fluid to a formation, so that the formation fractures; (2) placing non-phase-change liquid and phase-change liquid in different liquid mixing tanks and injecting into a shaft at the same time, an injection volume ratio of the non-phase-change liquid to the phase-change liquid is (0-0.7): (0.3-1); (3) injecting a displacement fluid into the shaft, so that the non-phase-change liquid and the phase-change liquid in the shaft completely enter a reservoir; (4) performing well shut-in and pressure-out for 30-200min, so that solid-phase matters generated by the phase-change liquid are laid in the fracture; and (5) relieving pressure to finish the construction.Type: ApplicationFiled: September 20, 2016Publication date: January 3, 2019Applicant: SOUTHWEST PETROLEUM UNIVERSITYInventors: Liqiang ZHAO, Yong YANG, Zhifeng LUO, Donghe YU, Juan DU, Guohua LIU, Hang CHE, Guangyan DU, Yuxin PEI, Nianyin LI, Pingli LIU, Kun XU, Bingxiao LIU
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Publication number: 20180340116Abstract: The present invention discloses a phase change fracturing fluid system for phase change fracturing, including the following components in percentage by weight: 10%-40% of supramolecular construction unit, 0-40% of supramolecular function unit, 0.5%-2% of surfactant, 0-5% of inorganic salt, 0.5%-2% of oxidizing agent, 0-2% of cosolvent and the remaining of solvent. The supramolecular construction unit is melamine, triallyl isocyanurate, or a mixture thereof. The supramolecular function unit is vinyl acetate, acrylonitrile, or a mixture thereof. The solvent is methylbenzene, ethylbenzene, o-xylene, m-xylene or p-xylene. In the fracturing construction process, a conventional fracturing fluid is used for fracturing a formation first; the phase change fracturing fluid is then injected into the formation, or the phase change fracturing fluid and other fluids which cannot be subjected to phase change are injected into the formation together.Type: ApplicationFiled: September 20, 2016Publication date: November 29, 2018Applicant: SOUTHWEST PETROLEUM UNIVERSITYInventors: Liqiang ZHAO, Yong YANG, Guangyan DU, Donghe YU, Juan DU, Hang CHE, Zhifeng LUO, Guohua LIU, Yuxin PEI, Nianyin LI, Pingli LIU, Kun XU