Abstract: The present invention relates to various crystalline forms of 6-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)nicotinamide. The present invention also relates to pharmaceutical compositions comprising the crystalline forms.

Abstract: The present disclosure relates to a medical imaging method for enabling magnetic resonance imaging of a subject (318) using a set of imaging parameters of imaging protocols, the method comprising: receiving information related to the subject; using a predefined machine learning model for suggesting at least one imaging protocol for the received information, wherein the imaging protocol comprises at least part of the set of imaging parameters and associated values; providing the imaging protocol.

Abstract: The present disclosure relates to a medical imaging method for enabling magnetic resonance imaging of a subject (318) using a set of imaging parameters of imaging protocols, the method comprising: receiving information related to the subject; using a predefined machine learning model for suggesting at least one imaging protocol for the received information, wherein the imaging protocol comprises at least part of the set of imaging parameters and associated values; providing the imaging protocol.

Abstract: The current invention relates to treatment of drug resistant melanoma with histone deacetylase inhibitors (HDACi). In particular the invention relates to BRAF and NRAS mutated melanoma and that have acquired resistance to MAPK pathway inhibitors, for example due to previous treatment with such MAPK pathway inhibitors. The invention discloses HDACi and/or MAPK pathway inhibitors for use in such treatment and treatment regimens using such inhibitors.

Abstract: The current invention relates to treatment of drug resistant melanoma with histone deacetylase inhibitors (HDACi). In particular the invention relates to BRAF and NRAS mutated melanoma and that have acquired resistance to MAPK pathway inhibitors, for example due to previous treatment with such MAPK pathway inhibitors. The invention discloses HDACi and/or MAPK pathway inhibitors for use in such treatment and treatment regimens using such inhibitors.

Abstract: Disclosed a voltage-deviation detecting and adjusting system for a balance module of a battery.

Abstract: Disclosed a voltage-deviation detecting and adjusting system for a balance module of a battery.

Abstract: Methods for actuating a microshutter array with electromechanical resonance and electrostatic force are described herein. An alternating electrical field is created by applying an alternating current (AC) voltage across a pair of actuation electrodes. A shutter blade with a blade electrode thereon is disposed between the pair of actuation electrodes and vibrates in the alternating electrical field created. Direct current (DC) voltages are applied to a vertical electrode and the blade electrode. The shutter blade is attracted to the vertical electrode and captured to an open position.

Abstract: The invention relates to an imaging system for use in operating rooms and other applications. According to one example, the imaging system includes a plurality of imaging sensors that receive image information from a subject via a plurality of spectral channels and that convert the image information into an image signal. The imaging system may include a plurality of independent imaging optics systems, such as an independent visible imaging optics system and an independent fluorescent imaging optics system, that optically couple the image information to the plurality of imaging sensors. The plurality of independent imaging optics systems corresponds to the plurality of image sensors in order to independently adjust a plurality of optical parameters, such as a size of a field of view, a position of a focal plane, and a size of an optical aperture.

Abstract: An anode assembly (50) includes a thermally conductive bearing encasement (52) covering a portion of a bearing (64). An anode (56) rotates on the bearing (64) and has a target (58) with an associated focal spot (60). The thermally conductive bearing encasement (52) is configured and expansion limited to prevent displacement of the focal spot (60) of greater than a predetermined displacement during operation of the anode (56).

Abstract: A clip for a motor stator housing to engage at least a first magnet and at least a second magnet of the motor stator includes a generally annular plate having an outer circumferential edge and an inner side. A plurality of outer tabs are radially arranged on the outer circumferential edge and extend outward relative to the outer circumferential edge, wherein the outer tabs engage an inner surface of the stator housing. At least a pair of first inner tabs extend outward from the inner side of the annular plate and are configured to engage opposing sidewalls of the first magnet. At least a pair of second inner tabs extend outward from the inner side of the annular plate and are configured to engage opposing sidewalls of the second magnet.

Abstract: An anode assembly (50) includes a thermally conductive bearing encasement (52) covering a portion of a bearing (64). An anode (56) rotates on the bearing (64) and has a target (58) with an associated focal spot (60). The thermally conductive bearing encasement (52) is configured and expansion limited to prevent displacement of the focal spot (60) of greater than a predetermined displacement during operation of the anode (56).

Abstract: A slotted window collector assembly for an x-ray tube having an anode and a cathode includes a collector having an anode side and a cathode side, which opposes the anode side. The anode side and the cathode side define an internal bore there between for receiving x-rays from the anode. The slotted collector further includes a window side common to both the anode side and the cathode side and having a window coupled thereto, wherein a window aperture is defined extending from the window to the internal bore. Within the collector assembly, a slot is defined intersecting the window aperture and extending trans-axially thereto and beyond a set length. The slot also extends circumferentially with the window such that plastic strain on the window and heat transferred to the window are reduced.

Abstract: A slotted window collector assembly for an x-ray tube having an anode and a cathode includes a collector having an anode side and a cathode side, which opposes the anode side. The anode side and the cathode side define an internal bore there between for receiving x-rays from the anode. The slotted collector further includes a window side common to both the anode side and the cathode side and having a window coupled thereto, wherein a window aperture is defined extending from the window to the internal bore. Within the collector assembly, a slot is defined intersecting the window aperture and extending trans-axially thereto and beyond a set length. The slot also extends circumferentially with the window such that plastic strain on the window and heat transferred to the window are reduced.

Abstract: An x-ray tube target assembly 16 provided. The target assembly 16 includes a target plate element 18 having an impact surface 24, a target rear surface 30, an inner target bore 22, and an outer target circumference 38. The target plate element 18 defines a target plate depth 32 between the impact surface 24 and the target rear surface 30. The target rear surface 30 is formed such that the target plate depth 32 tapers from an increased target plate depth 34 at the inner target bore to a decreased target plate depth 36 at the outer target circumference 38. The target assembly 16 further includes a graphite base element 28 having a base upper surface 42 and a base rear surface 44. The base upper surface 42 is formed to mate with the target rear surface 30.

Abstract: An x-ray tube target assembly 16 is provided. The assembly 16 includes a target disc element 18 having a target bore 22. A target shaft 20 transmits rotational drive to the target disc element 18. The target shaft 20 includes a plurality of axial adjustment slots 30 formed in an upper portion. The plurality of axial adjustment slots 30 are positioned around the target shaft 20 to form a plurality of partial circumferential ribs 36. The plurality of partial circumferential ribs 36 are brazed to the target bore 22.

Abstract: An x-ray tube target assembly 16 is provided. The assembly 16 includes a target disc element 18 having a target bore 22. A target shaft 20 transmits rotational drive to the target disc element 18. The target shaft 20 includes a plurality of axial adjustment slots 30 formed in an upper portion. The plurality of axial adjustment slots 30 are positioned around the target shaft 20 to form a plurality of partial circumferential ribs 36. The plurality of partial circumferential ribs 36 are brazed to the target bore 22.

Abstract: An x-ray tube target assembly 16 provided. The target assembly 16 includes a target plate element 18 having an impact surface 24, a target rear surface 30, an inner target bore 22, and an outer target circumference 38. The target plate element 18 defines a target plate depth 32 between the impact surface 24 and the target rear surface 30. The target rear surface 30 is formed such that the target plate depth 32 tapers from an increased target plate depth 34 at the inner target bore to a decreased target plate depth 36 at the outer target circumference 38. The target assembly 16 further includes a graphite base element 28 having a base upper surface 42 and a base rear surface 44. The base upper surface 42 is formed to mate with the target rear surface 30.

Abstract: An X-ray target material comprising an oxide-dispersion strengthened Mo (ODS-Mo) alloy. ODS-Mo refers to molybdenum strengthened by a fine dispersion of insoluble oxide particles of one or more of the following compounds: La2O3, Y2O3 and CeO2. ODS—Mo alloy improves upon the prior art by providing higher and more uniform strength and creep resistance over the applicable temperature range of large brazed graphite targets. This, in conjunction with higher-strength graphite, allows the target to spin faster without causing graphite burst, thus providing improvement in peak power. The recrystallization temperature of the fabricated material is high enough to maintain original properties through all target processing, including a very high-temperature braze cycle.