Patents by Inventor Liqun Chen

Liqun Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12201083
    Abstract: A generating device for simulating a particulate environment for an experimental animal includes an experimental chamber. An ultrasonic atomization device is installed at the bottom adjacent to the center of the experimental chamber. The upper side of the ultrasonic atomization device is connected to a guide device for guiding particles. The guide device includes an air seal cover, and a micro fan is installed inside the air seal cover to drive the movement of particles generated in the ultrasonic atomization device. Air guide pipes are fixedly connected to a side wall of the air seal cover. The generating device has good sealing performance, and can generate a variety of particle simulation environments to accurately and effectively simulate the biological effect of particles in the animal body. The generating device can improve the particle simulation environment, reduce the deviation of experimental data, and ensure the accuracy of the overall experimental data.
    Type: Grant
    Filed: November 28, 2022
    Date of Patent: January 21, 2025
    Assignee: THE ACADEMY OF TIANJIN UNIVERSITY, HEFEI
    Inventors: Guangjian Ni, Liqun Chen, Xinyu Gao, Yue Chen, Xiaoyu Guo
  • Publication number: 20240400570
    Abstract: This disclosure relates to bivalent compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the bivalent compounds, and to methods of use the bivalent compounds for the treatment of certain disease in a subject in need thereof. The disclosure also relates to methods for identifying such bivalent compounds.
    Type: Application
    Filed: May 3, 2024
    Publication date: December 5, 2024
    Inventors: Jing LIU, Michael Bruno PLEWE, Jialiang WANG, Xiaoran HAN, Liqun CHEN
  • Publication number: 20240364542
    Abstract: A communication method integrated with trustworthiness measurement, including: a first network element sends a first data packet, where the first data packet includes first request information, and the first request information is used to request to verify whether a second network element is trusted. The first network element receives a second data packet, where the second data packet includes first response information, and the first response information is used to verify whether the second network element is trusted.
    Type: Application
    Filed: July 3, 2024
    Publication date: October 31, 2024
    Applicant: HUAWEI TECHNOLOGIES CO., LTD.
    Inventors: Donghui WANG, Fei LIU, Liqun CHEN, Loganathan PARTHIPAN, Christopher J.P. NEWTON, Yunpeng LI
  • Publication number: 20240357360
    Abstract: This application provides a communication method integrated with trusted measurement and an apparatus. The method includes: A first network element sends a first request message, where the first request message is for requesting to verify whether terminal device is trusted. The first network element receives a first response message, where the first response message is for verifying whether the terminal device is trusted.
    Type: Application
    Filed: July 3, 2024
    Publication date: October 24, 2024
    Inventors: Christopher J.P. Newton, Liqun Chen, Fei Liu, Loganathan Parthipan, Donghui Wang, Yurong Song
  • Publication number: 20240354429
    Abstract: A method includes: a network function service consumer sends a service request message, where the service request message is used to request to obtain a service provided by a network function service provider. The network function service consumer receives a service response message, where the service response message indicates whether the service request message is accepted, and further indicates a result of trustworthiness verification of the network function service consumer. The method helps the network function service provider verify, before providing the network service, an identity of the network function service consumer and determine whether the network function service consumer is trusted, to help improve security of communication between core network elements and improve security of a core network device.
    Type: Application
    Filed: July 3, 2024
    Publication date: October 24, 2024
    Applicant: HUAWEI TECHNOLOGIES CO., LTD.
    Inventors: Yurong SONG, Fei LIU, Liqun CHEN, Donghui WANG, Christopher J.P. NEWTON, Loganathan PARTHIPAN, Yunpeng LI
  • Publication number: 20240346127
    Abstract: A trusted attestation method and a communication apparatus are provided. The method includes: A first node obtains information about a first blockchain, and the first node determines attestation information based on the information about the first blockchain. The attestation information is used to remotely attest whether the first node is trusted. The information about the first blockchain may be used as a common random number that is generated by the first blockchain based on a consensus and that can be used by a plurality of nodes. Therefore, the information about the first blockchain may be used as a challenge value for performing security measurement by the plurality of nodes. The attestation information may be verified by any verifier to implement measurement for one time and verification for a plurality of times, so that the first node does not need to establish a separate “challenge-response” procedure with each verifier.
    Type: Application
    Filed: June 21, 2024
    Publication date: October 17, 2024
    Inventors: Loganathan PARTHIPAN, Liqun CHEN, Christopher J.P. NEWTON, Fei LIU, Donghui WANG
  • Patent number: 12065442
    Abstract: Bivalent compounds, compositions comprising one or more of the bivalent compounds, and methods of use the bivalent compounds for the treatment of certain disease in a subject in need thereof are provided. Methods for identifying such bivalent compounds are provided, either.
    Type: Grant
    Filed: August 21, 2019
    Date of Patent: August 20, 2024
    Assignee: CULLGEN (SHANGHAI), INC.
    Inventors: Jing Liu, Liqun Chen
  • Publication number: 20240197694
    Abstract: Provided herein are compounds, pharmaceutical compositions, and methods for binding or modulating a DDB1- and CUL4-associated factor 1 (DCAF1) protein. Further provided herein are ligand-DCAF1 complexes or in vivo modified DCAF1 proteins.
    Type: Application
    Filed: March 14, 2022
    Publication date: June 20, 2024
    Inventors: Jing LIU, Michael Bruno PLEWE, Matthew Randolph LEE, Xiaoran HAN, Liqun CHEN, Ting YANG, Chengwei ZHANG, Jialiang WANG
  • Patent number: 11969472
    Abstract: This disclosure relates to bivalent compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the bivalent compounds, and to methods of use the bivalent compounds for the treatment of certain disease in a subject in need thereof. The disclosure also relates to methods for identifying such bivalent compounds.
    Type: Grant
    Filed: April 23, 2021
    Date of Patent: April 30, 2024
    Assignee: CULLGEN (SHANGHAI), INC.
    Inventors: Jialiang Wang, Xiaoran Han, Jing Liu, Liqun Chen
  • Publication number: 20240100170
    Abstract: Provided are bivalent compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the bivalent compounds, and methods of use the bivalent compounds for the treatment of certain disease in a subject in need thereof, and methods for identifying such bivalent compounds.
    Type: Application
    Filed: August 27, 2021
    Publication date: March 28, 2024
    Inventors: Jing LIU, Michael Bruno PLEWE, Jialiang WANG, Xiaoran HAN, Liqun CHEN, Chengwei ZHANG
  • Publication number: 20240066136
    Abstract: Provided herein are compounds, pharmaceutical compositions, and methods for binding or degrading target proteins. Further provided herein are compounds having a DNA damage-binding protein 1 (DDB1) binding moiety. Some such embodiments include a linker. Some such embodiments include a target protein binding moiety. Further provided herein are ligand-DDB1 complexes. Further provided herein are in vivo modified DDB1 proteins.
    Type: Application
    Filed: July 28, 2023
    Publication date: February 29, 2024
    Inventors: Jing LIU, Michael Bruno PLEWE, Matthew Randolph LEE, Xiaoran HAN, Liqun CHEN, Chengwei ZHANG, Jialiang WANG
  • Publication number: 20240059671
    Abstract: This disclosure relates to heterobifunctional compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the heterobifunctional compounds, and to methods of use the heterobifunctional compounds for the treatment of certain disease in a subject in need thereof. The disclosure also relates to methods for identifying such heterobifunctional compounds.
    Type: Application
    Filed: November 12, 2021
    Publication date: February 22, 2024
    Inventors: Jing LIU, Liqun CHEN, Jialiang WANG, Xiaoran HAN, Zhaohui WU, Ting YANG, Chengwei ZHANG
  • Publication number: 20240050428
    Abstract: This disclosure relates to GSPT1 degrader compounds (e.g. small molecule compounds), compositions comprising one or more of the compounds, and to methods of use the compounds for the treatment of certain disease in a subject in need thereof. The disclosure also relates to methods for identifying such compounds.
    Type: Application
    Filed: October 7, 2021
    Publication date: February 15, 2024
    Inventors: Jing LIU, Michael Bruno PLEWE, Jialiang WANG, Xiaoran HAN, Liqun CHEN, Ting YANG, Chengwei ZHANG
  • Publication number: 20230352638
    Abstract: A display panel includes a substrate, a plurality of light-emitting devices, a first encapsulation layer, and a first dielectric layer. The first encapsulation layer includes a first portion and a second portion at least partially surrounding the first portion. The first dielectric layer is located between the first encapsulation layer and the plurality of light-emitting devices. Along the direction perpendicular to the plane of the display panel, a distance between a surface of the first portion away from at least one light-emitting device of the plurality of light emitting devices and a surface of the third portion away from the at least one light-emitting device is smaller than a distance between a surface of the second portion away from the at least one light-emitting device and a surface of the fourth portion away from the at least one light-emitting device.
    Type: Application
    Filed: July 5, 2023
    Publication date: November 2, 2023
    Applicant: Shanghai Tianma Micro-Electronics Co., Ltd.
    Inventors: Liqun CHEN, Xiaoli LIU
  • Publication number: 20230257380
    Abstract: This disclosure relates to bivalent compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the bivalent compounds, and to methods of use the bivalent compounds for the treatment of certain disease in a subject in need thereof. The disclosure also relates to methods for identifying such bivalent compounds.
    Type: Application
    Filed: February 26, 2021
    Publication date: August 17, 2023
    Inventors: Jing LIU, Michael Bruno PLEWE, Jialiang WANG, Xiaoran HAN, Liqun CHEN, Chengwei ZHANG
  • Publication number: 20230097259
    Abstract: A generating device of simulating a particulate environment for an experimental animal includes an experimental chamber. An ultrasonic atomization device is installed at the bottom adjacent to the center of the experimental chamber. The upper side of the ultrasonic atomization device is connected to a guide device for guiding particles. The guide device includes an air seal cover, and a micro fan is installed inside the air seal cover to drive the movement of particles generated in the ultrasonic atomization device. Air guide pipes are fixedly connected to a side wall of the air seal cover. The generating device has good sealing performance, and can generate a variety of particle simulation environments to accurately and effectively simulate the biological effect of particles in the animal body. The generating device can improve the particle simulation environment, reduce the deviation of experimental data, and ensure the accuracy of the overall experimental data.
    Type: Application
    Filed: November 28, 2022
    Publication date: March 30, 2023
    Applicant: THE ACADEMY OF TIANJIN UNIVERSITY, HEFEI
    Inventors: Guangjian NI, Liqun CHEN, Xinyu GAO, Yue CHEN, Xiaoyu GUO
  • Publication number: 20230093099
    Abstract: This disclosure relates to heterobifunctional compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the heterobifunctional compounds, and to methods of use the heterobifunctional compounds for the treatment of certain disease in a subject in need thereof. The disclosure also relates to methods for identifying such heterobifunctional compounds.
    Type: Application
    Filed: April 2, 2020
    Publication date: March 23, 2023
    Inventors: Michael Bruno PLEWE, Jialiang Wang, Xiaoran Han, Liqun Chen
  • Publication number: 20230073777
    Abstract: Bivalent compounds composition comprises one or more of the bivalent compounds. The bivalent compound comprises a cyclic-AMP response element binding protein (CBP) and/or adenoviral EA binding protein of 300 kDa (P300) ligand (CBP/P3000 ligand) conjugated to a degradation tag. The method of using the bivalent compounds is treating certain disease in a subject in need thereof. The method of identifying such bivalent compounds is disclosed.
    Type: Application
    Filed: February 25, 2020
    Publication date: March 9, 2023
    Inventors: Jing Liu, Michael Bruno Plewe, Jialiang Wang, Xiaoran Han, Liqun Chen
  • Publication number: 20230057177
    Abstract: Provided herein are compounds, pharmaceutical compositions, and methods for binding or degrading target proteins. Further provided herein are compounds having a DNA damage-binding protein 1 (DDB1) binding moiety. Some such embodiments include a linker. Some such embodiments include a target protein binding moiety. Further provided herein are ligand-DDB1 complexes. Further provided herein are in vivo modified DDB1 proteins.
    Type: Application
    Filed: October 7, 2021
    Publication date: February 23, 2023
    Inventors: Jing LIU, Michael Bruno PLEWE, Matthew Randolph LEE, Xiaoran HAN, Liqun CHEN, Chengwei ZHANG, Jialiang WANG
  • Patent number: 11563566
    Abstract: According to an example, key splitting may include utilizing a masked version of a master key that is masked by using a mask.
    Type: Grant
    Filed: October 27, 2014
    Date of Patent: January 24, 2023
    Assignee: Micro Focus LLC
    Inventors: Stuart Haber, Liqun Chen