Abstract: Disclosed are a polyethylene glycol conjugate drug, and a preparation method therefor and the use thereof. Specifically, the present invention relates to a polyethylene glycol conjugate drug represented by formula A or a pharmaceutically acceptable salt thereof, a method for preparing the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, an intermediate for preparing the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, and the use of the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof in the preparation of a drug.

Abstract: A method for preparing a tar extract with aroma characteristics from a discarded cigarette butt includes: (1) adding the discarded cigarette butt to an extraction solvent, and carrying out subcritical fluid extraction to obtain an extraction solution; (2) carrying out vacuum filtration on the extraction solution, and carrying out vacuum distillation on the filtrate to obtain a concentrated extractum; and (3) carrying out molecular distillation on the concentrated extractum, and collecting a light fraction of the molecular distillation to obtain the tar extract with aroma characteristics. Through the subcritical fluid extraction and separation by the molecular distillation to prepare the tar extract, harmful substances in the tar are removed, and the aroma components are retained. The tar extract is applied to a cigarette to improve the aroma, smoke and taste characteristics of the cigarette.

Abstract: According to implementations of the subject matter described herein, there is provided a solution of providing a health index of a service. In this solution, a plurality of incident information sets associated with a plurality of services are obtained. The plurality of services are provisioned in a computing environment. An incident information set indicates at least one incident reported during operation of a service. Respective health indices are determined for the plurality of services based on respective ones of the plurality of incident information sets and a health classification policy. The respective health indices indicate respective health statuses of the plurality of services and being determined from a same health index range. Through unified use of incident information, the determined health indices can indicate universal and consistent health statuses for different services.

Abstract: A method for preparing a tar extract with aroma characteristics from a discarded cigarette butt includes: (1) adding the discarded cigarette butt to an extraction solvent, and carrying out subcritical fluid extraction to obtain an extraction solution; (2) carrying out vacuum filtration on the extraction solution, and carrying out vacuum distillation on the filtrate to obtain a concentrated extractum; and (3) carrying out molecular distillation on the concentrated extractum, and collecting a light fraction of the molecular distillation to obtain the tar extract with aroma characteristics. Through the subcritical fluid extraction and separation by the molecular distillation to prepare the tar extract, harmful substances in the tar are removed, and the aroma components are retained. The tar extract is applied to a cigarette to improve the aroma, smoke and taste characteristics of the cigarette.

Abstract: The present disclosure provides a method for extracting tar aroma components from a cigarette butt and use of the tar aroma components in a cigarette. The method includes the following steps: (1) adding the cigarette butt to an extraction solvent, and carrying out ultrasound-assisted extraction to obtain an extraction solution; (2) centrifuging the extraction solution, and carrying out vacuum distillation on the supernatant to obtain a concentrated extractum; and (3) carrying out molecular distillation on the concentrated extractum, and collecting a light fraction of the molecular distillation to obtain the tar aroma components. In the present disclosure, the cigarette butt is used as a raw material, through the ultrasound-assisted extraction and separation by the molecular distillation to extract the tar, harmful substances in the tar are removed, and the aroma components are retained.

Abstract: A method for preparing a tar extract from a discarded cigarette butt and use of the tar extract in a cigarette includes the following steps: (1) adding the discarded cigarette butt to an extraction solvent, and carrying out microwave-assisted extraction to obtain an extraction solution; and (2) centrifuging the extraction solution, carrying out silica gel column chromatography on the supernatant, carrying out elution by using a petroleum ether-ethyl acetate mixed solution as a mobile phase, and collecting the resulting elution fraction to obtain the tar extract. In the method, the tar is extracted from the discarded cigarette butt as a raw material. Through the microwave-assisted extraction and separation by the silica gel column chromatography, harmful substances in the tar of the cigarette butt are removed, and the components with aroma characteristics are retained, and the tar extract is applied to a low-end cigarette.

Abstract: The subject matter described herein relates to light based positioning. In one embodiment, a method comprises: responsive to receiving a light signal from at least one light source available to the device, decoding a beacon from the received light signal, the beacon associated with the at least one light source; measuring signal strength of the received light signal; and determining a position of the device at least in part based on the decoded beacon, the measured signal strength, and number of the at least one light source. In addition, the frequency channelization and random channel hopping may be utilized to further improve the performance.

Abstract: Disclosed herein are techniques and systems for performing wireless-based localization using a zonal framework. An area (i.e., surface or space) may be partitioned into multiple zones, and one or more signal propagation models for one or more wireless access points (APs) may be generated for each zone. The result is a set of zonal signal propagation models that allow for improved model fitness on a per-zone basis. A process includes receiving a location query associated with a wireless communication device, selecting a target zone among multiple available zones of an area, and estimating a location of the wireless communication device based at least in part on one of a signal propagation model associated with the target zone or a fingerprint-based localization. The signal propagation model associated with the target zone may be generated based on training samples observed exclusively within the target zone.

Abstract: A view adjustment system using information captured by one or more sensors on a client device determines a projection direction for content to be displayed on a display of the client device. Upon determining the projection direction, the view adjustment system transforms the content into a perspective view based on the determined projection direction and prompts the client device to present the content in the perspective view to a user. The view adjustment system may monitor changes in relative position and/or direction of the user with respect to the display, adjust the projection direction, and transform the content to reflect these changes.

Abstract: The subject matter described herein relates to light based positioning. In one embodiment, a method comprises: responsive to receiving a light signal from at least one light source available to the device, decoding a beacon from the received light signal, the beacon associated with the at least one light source; measuring signal strength of the received light signal; and determining a position of the device at least in part based on the decoded beacon, the measured signal strength, and number of the at least one light source. In addition, the frequency channelization and random channel hopping may be utilized to further improve the performance.

Abstract: Disclosed herein are techniques and systems for performing wireless-based localization using a zonal framework. An area (i.e., surface or space) may be partitioned into multiple zones, and one or more signal propagation models for one or more wireless access points (APs) may be generated for each zone. The result is a set of zonal signal propagation models that allow for improved model fitness on a per-zone basis. A process includes receiving a location query associated with a wireless communication device, selecting a target zone among multiple available zones of an area, and estimating a location of the wireless communication device based at least in part on one of a signal propagation model associated with the target zone or a fingerprint-based localization. The signal propagation model associated with the target zone may be generated based on training samples observed exclusively within the target zone.

Abstract: A view adjustment system using information captured by one or more sensors on a client device determines a projection direction for content to be displayed on a display of the client device. Upon determining the projection direction, the view adjustment system transforms the content into a perspective view based on the determined projection direction and prompts the client device to present the content in the perspective view to a user. The view adjustment system may monitor changes in relative position and/or direction of the user with respect to the display, adjust the projection direction, and transform the content to reflect these changes.