Abstract: This disclosure relates to bivalent compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the bivalent compounds, and to methods of use the bivalent compounds for the treatment of certain disease in a subject in need thereof. The disclosure also relates to methods for identifying such bivalent compounds.

Abstract: Provided are a vibration object monitoring method and apparatus, a computer device, and a storage medium. The method includes: in response to detecting that a vibration object exists in a monitoring video picture for a target monitoring region, a vibration object region in the monitoring video picture is determined, where the vibration object region is a region where the vibration object is located in the monitoring video picture; displacement information of a key point of the vibration object in the vibration object region is recorded; vibration information of the vibration object in the monitoring video picture is determined based on the displacement information; and a vibration object monitoring result for the target monitoring region is generated according to the vibration information. The abnormal vibration monitoring can be performed on the vibration object in the target monitoring region in time according to this method.

Abstract: Embodiments of a disconnector and a switchgear, wherein the disconnector comprises a contact assembly operable to change a status of a circuit, the disconnector arranged in the circuit; shafts adapted to be driven to rotate to operate the contact assembly; and a transmission unit arranged between the shafts and comprising: a plurality of gears coupled to the shafts to enable the shafts to rotate with a mutual engagement of the plurality of gears; and a holding assembly adapted to hold radial positions of the plurality of gears to ensure the mutual engagement of the plurality of gears. By arranging the holding assembly to hold the radial positions of the gears to ensure the mutual engagement of the plurality of gears, only one input shaft and one transmission unit are enough to transmit large torques sufficient to operate the contact assembly.

Abstract: Disclosed are a polyethylene glycol conjugate drug, and a preparation method therefor and the use thereof. Specifically, the present invention relates to a polyethylene glycol conjugate drug represented by formula A or a pharmaceutically acceptable salt thereof, a method for preparing the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, an intermediate for preparing the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof, and the use of the polyethylene glycol conjugate drug or the pharmaceutically acceptable salt thereof in the preparation of a drug.

Abstract: Provided are bivalent compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the bivalent compounds, and methods of use the bivalent compounds for the treatment of certain disease in a subject in need thereof, and methods for identifying such bivalent compounds.

Abstract: Provided herein are compounds, pharmaceutical compositions, and methods for binding or degrading target proteins. Further provided herein are compounds having a DNA damage-binding protein 1 (DDB1) binding moiety. Some such embodiments include a linker. Some such embodiments include a target protein binding moiety. Further provided herein are ligand-DDB1 complexes. Further provided herein are in vivo modified DDB1 proteins.

Abstract: In one embodiment, a test system comprises: a network access point simulation component, a local control component, and a reference component. The network access point simulation component is configured to simulate communication network access point operations comprising test interactions with user equipment. The number of devices under test included in the user equipment and distinct network access points that are coincidentally simulated are variable. The local control component is configured to direct the network access point simulation component and to control the test interactions with the user equipment. The local control component comprises a test executive operable to direct simulation of communication network operations and the test interactions in accordance with information received from the remote control components. The reference component is operable to communicatively couple with the network access point simulation component similar to the user equipment and validate the test interactions.

Abstract: In one embodiment, a test system comprises a first interface for communicating with remote devices; a second interface for communicating with local devices; a memory for storing information, including information received from the first interface and second interface; a processor for automatically configuring test system components in accordance with the information stored in the memory. The test system components comprise a network access point simulation component and a local control component. The network access point simulation component is configured to simulate communication network access point operations comprising test interactions with user equipment. The number of devices under test included in the user equipment and distinct network access points that are coincidentally simulated can be variable. The local control component is configured to direct the network access point simulation component and to control the test interactions with the user equipment.

Abstract: In one embodiment, a test system comprises: a network access point simulation component configured to simulate network access point operations and to simulate test interactions with user equipment, and a local control component configured to direct the network access point simulation component and to control test interactions with the user equipment. The number of devices under test included in the user equipment and distinct network access points that are coincidentally simulated are variable. In one exemplary implementation, the local control component comprises a test executive operable to direct simulation of communication network operations and the test interactions in accordance with information received from the remote control components. The network access point simulation component and local control component are portable.

Abstract: Cloud-based management of cell-based test systems is described. For example, at a server that is communicatively coupled to a cell-based test system via a network (that is, in the cloud), a test case from a test case library is selected and accessed. The test case is selected according to the type of user equipment to be tested at the cell-based test system. The test case is sent from the server over the network to the cell-based test system. The cell-based test system can automatically perform the test case on the user equipment. Results from performing the test case on the user equipment are then stored on the cloud; that is, the test results are received at the server from the cell-based test system over the network and stored at the server. A report based on the test results can be prepared and stored on the server (in the cloud).

Abstract: To test user equipment at a cell-based test system, a type of user equipment to be tested is determined. A device profile for the type of the user equipment to be tested is accessed. The device profile includes, for example, a test script that can be used to control the user equipment during the testing. A test of the user equipment is performed at the cell-based test system. During the test, the user equipment is controlled according to the device profile in response to the software executing on a computer system.

Abstract: In one embodiment, a test system comprises: a network access point simulation component configured to simulate network access point operations and to simulate test interactions with user equipment, and a local control component configured to direct the network access point simulation component and to control test interactions with the user equipment. The number of devices under test included in the user equipment and distinct network access points that are coincidentally simulated are variable. In one exemplary implementation, the local control component comprises a test executive operable to direct simulation of communication network operations and the test interactions in accordance with information received from the remote control components. The network access point simulation component and local control component are portable.

Abstract: In one embodiment, a test system comprises a first interface for communicating with remote devices; a second interface for communicating with local devices; a memory for storing information, including information received from the first interface and second interface; a processor for automatically configuring test system components in accordance with the information stored in the memory. The test system components comprise a network access point simulation component and a local control component. The network access point simulation component is configured to simulate communication network access point operations comprising test interactions with user equipment. The number of devices under test included in the user equipment and distinct network access points that are coincidentally simulated can be variable. The local control component is configured to direct the network access point simulation component and to control the test interactions with the user equipment.

Abstract: Cloud-based management of cell-based test systems is described. For example, at a server that is communicatively coupled to a cell-based test system via a network (that is, in the cloud), a test case from a test case library is selected and accessed. The test case is selected according to the type of user equipment to be tested at the cell-based test system. The test case is sent from the server over the network to the cell-based test system. The cell-based test system can automatically perform the test case on the user equipment. Results from performing the test case on the user equipment are then stored on the cloud; that is, the test results are received at the server from the cell-based test system over the network and stored at the server. A report based on the test results can be prepared and stored on the server (in the cloud).

Abstract: In one embodiment, a test system comprises: a network access point simulation component, a local control component, and a reference component. The network access point simulation component is configured to simulate communication network access point operations comprising test interactions with user equipment. The number of devices under test included in the user equipment and distinct network access points that are coincidentally simulated are variable. The local control component is configured to direct the network access point simulation component and to control the test interactions with the user equipment. The local control component comprises a test executive operable to direct simulation of communication network operations and the test interactions in accordance with information received from the remote control components. The reference component is operable to communicatively couple with the network access point simulation component similar to the user equipment and validate the test interactions.

Abstract: To test user equipment at a cell-based test system, a type of user equipment to be tested is determined. A device profile for the type of the user equipment to be tested is accessed. The device profile includes, for example, a test script that can be used to control the user equipment during the testing. A test of the user equipment is performed at the cell-based test system. During the test, the user equipment is controlled according to the device profile in response to the software executing on a computer system.