Patents by Inventor Lirina Valeryevna Ivanovskaya

Lirina Valeryevna Ivanovskaya has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mutant ilvH gene and method for producing L-valine
    Patent number: 6737255
    Abstract: The present invention provides an isolated DNA molecule encoding a small subunit of acetohydroxy acid synthase isozyme III originating from Escherichia coli and mutants of Escherichia coli acetohydroxy acid synthase isozyme III, which are free from inhibition by L-valine an can catalyze the conversion of: (a) pyruvate to &agr;-acetolactate and (b) &agr;-ketobutyrate and pyruvate to &agr;-aceto-a-hydroxybutyrate. The present invention also provides methods for producing L-valine by fermentation of a bacterium harboring the novel DNA molecule and/or expressing the mutant acetohydroxy acid synthase isozyme III.
    Type: Grant
    Filed: January 18, 2001
    Date of Patent: May 18, 2004
    Assignee: Ajinomoto Co., Inc.
    Inventors: Vitaliy Arkadyevich Livshits, Vera Georgievna Doroshenko, Nataliya Vasilyevna Gorshkova, Alla Valentinovna Belaryeva, Lirina Valeryevna Ivanovskaya, Evgeni Moiseevich Khourges, Valery Zavenovich Akhverdian, Mikhail Markovich Gusyatiner, Yury Ivanovich Kozlov
  • Mutant ilvH gene and method for producing L-valine
    Publication number: 20020037562
    Abstract: A method for producing L-valine comprising the steps of cultivating the bacterium harboring a DNA coding for actohydroxy acid synthase isozime III originating from Escherichia coli which is free from a inhibition by L-valine and has an activity to catalyze two reactions to generate &agr;-acetolactate from pyruvate and &agr;-aceto-&agr;-hydroxybutyrate from &agr;-ketobutyrate and pyruvate, producing and accumulating L-valine in the culture medium, and collecting L-valine from the culture medium.
    Type: Application
    Filed: January 18, 2001
    Publication date: March 28, 2002
    Applicant: AJINOMOTO CO., INC.
    Inventors: Vitaliy Arkadyevich Livshits, Vera Georgievna Doroshenko, Nataliya Vasilyevna Gorshkova, Alla Valentinovna Belaryeva, Lirina Valeryevna Ivanovskaya, Evgeni Moiseevich Khourges, Valery Zavenovich Akhverdian, Mikhail Markovich Gusyatiner, Yury Ivanovich Kozlov