Abstract: The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).

Abstract: The invention relates to substituted pyrazolo piperidine carboxylic acids, their salts and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular cardiovascular and cardiac diseases, preferably heart failure with reduced and preserved ejection fraction (HFrEF, HFmrEF and HFpEF), hypertension (HTN), peripheral arterial diseases (PAD, PAOD), cardio-renal and kidney diseases, preferably chronic and diabetic kidney disease (CKD and DKD), cardiopulmonary and lung diseases, preferable pulmonary hypertension (PH), and other diseases, preferably neurodegenerative diseases and different forms of dementias, fibrotic diseases, systemic sclerosis (SSc), sickle cell disease (SCD), wound healing disorders such as diabetic foot ulcer (DFU).

Abstract: A non-toxic unitary lice deterring and preventive headband is worn upon the scalp of a wearer. The headband does not use coatings or removable strips, or other reservoirs attached to the headband. The aromatic essential oils are preferably a 1.65% mixture by weight of citronella oil, rosemary oil, lemongrass oil and geranium oil, where the mixture is infused by further admixing in a resin of the styrene butadiene copolymer in an amount of 98.55% by weight. The raw plastic resin material, such as styrene butadiene copolymer, is first premixed and preheated into a malleable, pourable state, which is then admixed with the mixture of aromatic essential oils. The admixture of the plastic resin and aromatic essential oils is then injected into a headband-shaped mold The molded, admixed material is already prepared with lice deterring aromatic essential oils, when the molded, admixed plastic material is molded into a headband shape.

Abstract: A disposable grease collection container which is provided with a bottom and four upstanding walls. The container further having an outer surface and an inner surface wherein the inner surface forms a collection area where the grease is collected. The inner surface is of disposable material that is heat resistant to the grease being collected therein, and the outer surface of the container is of a disposable material being light-weight but having a thickness selected to provide sufficient rigidity to be self-supporting so that the container maintains its shape and the four walls remain upstanding. Each of the end walls of the container having a bellows-like portion formed as an integral part of the outer surface. The bellows-like portion designed to further provide rigidity and support to the container.