Patents by Inventor Lisa A. Racie

Lisa A. Racie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aggrecanase molecules
    Patent number: 7125701
    Abstract: Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
    Type: Grant
    Filed: July 26, 2002
    Date of Patent: October 24, 2006
    Assignee: Wyeth
    Inventors: Michael J. Agostino, Lisa A. Racie
  • Modified ADAMTS4 molecules and method of use thereof
    Publication number: 20060228354
    Abstract: The present invention relates to modified ADAMTS4 proteins having improved stability comparing to the corresponding native, unmodified proteins. The modified ADAMTS4 proteins can be expressed and isolated in large quantities, thus allowing further characterization of the proteins, such as crystallographic and enzyme kinetic studies. The purified, stable proteins would also facilitate the production of anti-ADAMTS antibodies and the development of inhibitors to ADAMTS enzymes.
    Type: Application
    Filed: June 12, 2006
    Publication date: October 12, 2006
    Applicant: Wyeth
    Inventors: Christopher Corcoran, Carl Flannery, Weilan Zeng, Lisa Racie, Thomas McDonagh, Bethany Freeman, Katy Georgiadis, Edward LaVallie
  • Modified ADAMTS4 molecules and method of use thereof
    Patent number: 7118902
    Abstract: The present invention relates to modified ADAMTS4 proteins having improved stability comparing to the corresponding native, unmodified proteins. The modified ADAMTS4 proteins can be expressed and isolated in large quantities, thus allowing further characterization of the proteins, such as crystallographic and enzyme kinetic studies. The purified, stable proteins would also facilitate the production of anti-ADAMTS antibodies and the development of inhibitors to ADAMTS enzymes.
    Type: Grant
    Filed: July 29, 2003
    Date of Patent: October 10, 2006
    Assignee: Wyeth
    Inventors: Christopher John Corcoran, Carl R. Flannery, Weilan Zeng, Lisa A. Racie, Thomas McDonagh, Bethany A. Freeman, Katy E. Georgiadis, Edward R. LaVallie
  • Human SDF-5 protein and compositions
    Publication number: 20060111562
    Abstract: Purified human SDF-5 proteins and processes for producing them are disclosed. DNA molecules encoding the human SDF-5 proteins are also disclosed. The proteins may be used in regulating the binding of Wnt genes to their receptor. In preferred embodiments, the proteins may be used for inducing formation, growth, differentiation, proliferation and/or maintenance of chondrocytes and/or cartilage tissue, and for other tissue repair, such as pancreatic tissue repair.
    Type: Application
    Filed: December 16, 2005
    Publication date: May 25, 2006
    Applicant: Genetics Institute, LLC
    Inventors: Edward LaVallie, Lisa Racie, Gary Hattersley
  • Human SDF-5 protein and compositions
    Patent number: 7026445
    Abstract: Purified human SDF-5 proteins and processes for producing them are disclosed. DNA molecules encoding the human SDF-5 proteins are also disclosed. The proteins may be used in regulating the binding of Wnt genes to their receptor. In preferred embodiments, the proteins may be used for inducing formation, growth, differentiation, proliferation and/or maintenance of chondrocytes and/or cartilage tissue, and for other tissue repair, such as pancreatic tissue repair.
    Type: Grant
    Filed: October 15, 1997
    Date of Patent: April 11, 2006
    Assignee: Genetics Institute, LLC
    Inventors: Edward R. LaVallie, Lisa A. Racie, Gary Hattersley
  • Modified ADAMTS4 molecules and method of use thereof
    Publication number: 20040142863
    Abstract: The present invention relates to modified ADAMTS4 proteins having improved stability comparing to the corresponding native, unmodified proteins. The modified ADAMTS4 proteins can be expressed and isolated in large quantities, thus allowing further characterization of the proteins, such as crystallographic and enzyme kinetic studies. The purified, stable proteins would also facilitate the production of anti-ADAMTS antibodies and the development of inhibitors to ADAMTS enzymes.
    Type: Application
    Filed: July 29, 2003
    Publication date: July 22, 2004
    Applicant: WYETH
    Inventors: Christopher John Corcoran, Carl R. Flannery, Weilan Zeng, Lisa A. Racie, Thomas McDonagh, Bethany A. Freeman, Katy E. Georgiadis, Edward R. LaVallie
  • Aggrecanase molecules
    Patent number: 6689599
    Abstract: Aggrecanase proteins and the nucleotides sequences encoding them as well as processes for producing them are disclosed. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
    Type: Grant
    Filed: October 18, 2001
    Date of Patent: February 10, 2004
    Assignee: Genetics Institute, LLC
    Inventors: Lisa A. Racie, Natalie C. Twine, Michael J. Agostino, Neil Wolfman, Elisabeth A. Morris
  • Aggrecanase molecules
    Publication number: 20030228676
    Abstract: Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
    Type: Application
    Filed: December 30, 2002
    Publication date: December 11, 2003
    Inventors: Michael J. Agostino, Elizabeth DiBlasio, Edward R. Lavallie, Bethany A. Freeman, Lisa A. Racie, Weilan Zeng
  • HUMAN SDF-5 PROTEIN AND COMPOSITIONS
    Publication number: 20030175855
    Abstract: Purified human SDF-5 proteins and processes for producing them are disclosed. DNA molecules encoding the human SDF-5 proteins are also disclosed. The proteins may be used in regulating the binding of Wnt genes to their receptor. In preferred embodiments, the proteins may be used for inducing formation, growth, differentiation, proliferation and/or maintenance of chondrocytes and/or cartilage tissue, and for other tissue repair, such as pancreatic tissue repair.
    Type: Application
    Filed: October 15, 1997
    Publication date: September 18, 2003
    Inventors: EDWARD R. LAVALLIE, LISA A. RACIE
  • Aggrecanase molecules
    Publication number: 20030148306
    Abstract: Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
    Type: Application
    Filed: July 5, 2002
    Publication date: August 7, 2003
    Inventors: Michael J. Agostino, Elizabeth Di Blasio, Edward R. LaVallie, Lisa A. Racie
  • Aggrecanase molecules
    Publication number: 20030105313
    Abstract: Novel aggrecanase proteins and the nucleotides sequences encoding them as well as processes for producing them are disclosed. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
    Type: Application
    Filed: January 25, 2002
    Publication date: June 5, 2003
    Applicant: American Home Products Corporation
    Inventors: Lisa A. Racie, Natalie C. Twine, Michael J. Agostino, Neil Wolfman, Elisabeth A. Morris
  • Secreted proteins and polynucleotides encoding them
    Publication number: 20030100053
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Application
    Filed: October 30, 2001
    Publication date: May 29, 2003
    Applicant: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. La Vallie, Lisa A. Racie, Cheryl Evans, David Merberg, Sha Mi, Maurice Treacy
  • Aggrecanase molecules
    Publication number: 20030092621
    Abstract: Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
    Type: Application
    Filed: July 26, 2002
    Publication date: May 15, 2003
    Inventors: Michael J. Agostino, Lisa A. Racie
  • Secreted expressed sequence tags (sESTs)
    Publication number: 20020173635
    Abstract: Secreted expressed sequence tags (sESTs) isolated from a varie
    Type: Application
    Filed: January 7, 2002
    Publication date: November 21, 2002
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Vikki Spaulding, Michael J. Agostino
  • Secreted proteins
    Publication number: 20020165151
    Abstract: Novel proteins and methods of treatment using same are disclosed.
    Type: Application
    Filed: January 7, 2002
    Publication date: November 7, 2002
    Inventors: Kenneth Jacobs, John M. McCoy, Lisa A. Racie, Edward R. LaVallie, Maurice Treacy, Cheryl Evans, Michael J. Agostino, Zhijian Lu, David Merberg, Kei Tashiro, Tomoyuki Nakamura, Tasuku Honjo
  • Aggrecanase molecules
    Publication number: 20020151702
    Abstract: Novel aggrecanase proteins and the nucleotides sequences encoding them as well as processes for producing them are disclosed. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
    Type: Application
    Filed: October 16, 2001
    Publication date: October 17, 2002
    Applicant: Genetics Institute, Inc.
    Inventors: Lisa A. Racie, Natalie C. Twine, Michael J. Agostino, Neil Wolfman, Elisabeth A. Morris
  • Secreted proteins and polynucleotides encoding them
    Publication number: 20020146769
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Application
    Filed: January 7, 2002
    Publication date: October 10, 2002
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Cheryl Evans, Vikki Spaulding
  • Secreted proteins
    Patent number: 6451318
    Abstract: Novel proteins are disclosed.
    Type: Grant
    Filed: July 26, 2000
    Date of Patent: September 17, 2002
    Assignee: Genetics Institute, LLC
    Inventors: Kenneth Jacobs, John M. McCoy, Lisa A. Racie, Edward R. La Vallie, David Merberg, Maurice Treacy, Vikki Spaulding, Michael J. Agostino
  • Secreted proteins
    Publication number: 20020106356
    Abstract: Novel proteins are disclosed.
    Type: Application
    Filed: August 28, 2001
    Publication date: August 8, 2002
    Inventors: Kenneth Jacobs, John M. McCoy, Lisa A. Racie, Edward R. LaVallie, David Merberg, Maurice Treacy, Cheryl Evans
  • Secreted proteins and polynucleotides encoding them
    Patent number: 6312921
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: October 20, 1998
    Date of Patent: November 6, 2001
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, Cheryl Evans, David Merberg, Sha Mi, Maurice Treacy