Patents by Inventor Lisa A. Scott-Carnell
Lisa A. Scott-Carnell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10406346Abstract: A method and device for promoting healing of an injury in a living being are provided. Such method and device are based upon an injury covering portion, which portion comprises an electroactive polymer, such as poled polyvinylidine difluoride (PVDF) or a copolymer of PVDF. The electroactive polymer has either pyroelectric properties, piezoelectric properties, or both.Type: GrantFiled: February 3, 2010Date of Patent: September 10, 2019Assignee: UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASAInventors: Lisa A. Scott-Carnell, Emilie J. Siochi, Kam W. Leong
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Patent number: 10196603Abstract: A method of manufacturing and/or using a scaffold assembly for stem cell culture and tissue engineering applications is disclosed. The scaffold at least partially mimics a native biological environment by providing biochemical, topographical, mechanical and electrical cues by using an electroactive material. The assembly includes at least one layer of substantially aligned, electrospun polymer fiber having an operative connection for individual voltage application. A method of cell tissue engineering and/or stem cell differentiation that uses the assembly seeded with a sample of cells suspended in cell culture media, incubates and applies voltage to one or more layers, and thus produces cells and/or a tissue construct.Type: GrantFiled: August 3, 2017Date of Patent: February 5, 2019Assignee: The United States of America as represented by the Administrator of NASAInventors: Lisa A. Scott Carnell, Emilie J. Siochi, Nancy M. Holloway, Kam W. Leong, Karina Kulangara
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Publication number: 20170355954Abstract: A method of manufacturing and/or using a scaffold assembly for stem cell culture and tissue engineering applications is disclosed. The scaffold at least partially mimics a native biological environment by providing biochemical, topographical, mechanical and electrical cues by using an electroactive material. The assembly includes at least one layer of substantially aligned, electrospun polymer fiber having an operative connection for individual voltage application. A method of cell tissue engineering and/or stem cell differentiation that uses the assembly seeded with a sample of cells suspended in cell culture media, incubates and applies voltage to one or more layers, and thus produces cells and/or a tissue construct.Type: ApplicationFiled: August 3, 2017Publication date: December 14, 2017Inventors: Lisa A. Scott Carnell, Emilie J. Siochi, Nancy M. Holloway, Kam W. Leong, Karina Kulangara
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Patent number: 9758761Abstract: A method of manufacturing and/or using a scaffold assembly for stem cell culture and tissue engineering applications is disclosed. The scaffold at least partially mimics a native biological environment by providing biochemical, topographical, mechanical and electrical cues by using an electroactive material. The assembly includes at least one layer of substantially aligned, electrospun polymer fiber having an operative connection for individual voltage application. A method of cell tissue engineering and/or stem cell differentiation that uses the assembly seeded with a sample of cells suspended in cell culture media, incubates and applies voltage to one or more layers, and thus produces cells and/or a tissue construct.Type: GrantFiled: April 13, 2015Date of Patent: September 12, 2017Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: Lisa A. Scott Carnell, Emilie J. Siochi, Nancy M. Holloway, Kam W. Leong, Karina Kulangara
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Patent number: 9557322Abstract: An apparatus and method that utilizes a radiation source and a simulated microgravity to provide combined stressors. The response of cells/bacteria/viruses and/or other living matter to the combined stressors can be evaluated to predict the effects of extended space missions. The apparatus and method can also be utilized to study diseases and to develop new treatments and vaccinations.Type: GrantFiled: June 26, 2014Date of Patent: January 31, 2017Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventor: Lisa A. Scott Carnell
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Publication number: 20150218510Abstract: A method of manufacturing and/or using a scaffold assembly for stem cell culture and tissue engineering applications is disclosed. The scaffold at least partially mimics a native biological environment by providing biochemical, topographical, mechanical and electrical cues by using an electroactive material. The assembly includes at least one layer of substantially aligned, electrospun polymer fiber having an operative connection for individual voltage application. A method of cell tissue engineering and/or stem cell differentiation that uses the assembly seeded with a sample of cells suspended in cell culture media, incubates and applies voltage to one or more layers, and thus produces cells and/or a tissue construct.Type: ApplicationFiled: April 13, 2015Publication date: August 6, 2015Inventors: Lisa A. Scott Carnell, Emilie J. Siochi, Nancy M. Holloway, Kam W. Leong, Karina Kulangara
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Patent number: 9005604Abstract: A scaffold assembly and related methods of manufacturing and/or using the scaffold for stem cell culture and tissue engineering applications are disclosed which at least partially mimic a native biological environment by providing biochemical, topographical, mechanical and electrical cues by using an electroactive material. The assembly includes at least one layer of substantially aligned, electrospun polymer fiber having an operative connection for individual voltage application. A method of cell tissue engineering and/or stem cell differentiation uses the assembly seeded with a sample of cells suspended in cell culture media, incubates and applies voltage to one or more layers, and thus produces cells and/or a tissue construct.Type: GrantFiled: December 15, 2010Date of Patent: April 14, 2015Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: Lisa A. Scott-Carnell, Emilie J. Siochi, Nancy M. Holloway, Kam W. Leong, Karina Kulangara
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Publication number: 20150004614Abstract: An apparatus and method that utilizes a radiation source and a simulated microgravity to provide combined stressors. The response of cells/bacteria/viruses and/or other living matter to the combined stressors can be evaluated to predict the effects of extended space missions. The apparatus and method can also be utilized to study diseases and to develop new treatments and vaccinations.Type: ApplicationFiled: June 26, 2014Publication date: January 1, 2015Inventor: Lisa A. Scott Carnell
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Patent number: 8378659Abstract: A method for monitoring the structural health of a structure of interest by coupling one or more electroactive polymer fibers to the structure and monitoring the electroactive responses of the polymer fiber(s). Load changes that are experienced by the structure cause changes in the baseline responses of the polymer fiber(s). A system for monitoring the structural health of the structure is also provided.Type: GrantFiled: February 10, 2010Date of Patent: February 19, 2013Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: Lisa A. Scott-Carnell, Emilie J. Siochi
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Patent number: 7993567Abstract: A method and system are provided for aligning fibers in an electrospinning process. A jet of a fiberizable material is directed towards an uncharged collector from a dispensing location that is spaced apart from the collector. While the fiberizable material is directed towards the collector, an elliptical electric field is generated via the electrically charged dispenser and an oppositely-charged control location. The field spans between the dispensing location and the control location that is within line-of-sight of the dispensing location, and impinges upon at least a portion of the collector. Various combinations of numbers and geometries of dispensers, collectors, and electrodes can be used.Type: GrantFiled: June 2, 2008Date of Patent: August 9, 2011Assignee: The United States of America as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: Lisa A. Scott-Carnell, Ralph M Stephens, Nancy M. Holloway, Caroline Rhim, Laura Niklason, Robert L. Clark, Emilie J. Siochi
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Publication number: 20110142806Abstract: A scaffold assembly and related methods of manufacturing and/or using the scaffold for stem cell culture and tissue engineering applications are disclosed which at least partially mimic a native biological environment by providing biochemical, topographical, mechanical and electrical cues by using an electroactive material. The assembly includes at least one layer of substantially aligned, electrospun polymer fiber having an operative connection for individual voltage application. A method of cell tissue engineering and/or stem cell differentiation uses the assembly seeded with a sample of cells suspended in cell culture media, incubates and applies voltage to one or more layers, and thus produces cells and/or a tissue construct.Type: ApplicationFiled: December 15, 2010Publication date: June 16, 2011Applicant: USA as represented by the Administrator of the National Aeronautics and Space AdmInventors: Lisa A. Scott-Carnell, Emilie J. Siochi, Nancy M. Holloway, Kam W. Leong, Karina Kulangara
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Publication number: 20100211151Abstract: Embodiments of the invention include a method and device for promoting healing of an injury in a living being. The embodiments comprise an injury covering portion, which portion comprises an electroactive polymer, such as poled polyvinylidine difluoride (PVDF) or a copolymer of PVDF. The electroactive polymer has either pyroelectric properties, piezoelectric properties, or both.Type: ApplicationFiled: February 3, 2010Publication date: August 19, 2010Applicant: U.S.A. as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: LISA A. SCOTT-CARNELL, EMILIE J. SIOCHI, KAM W. LEONG
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Publication number: 20100201384Abstract: One or more electroactive polymer fibers are coupled to a structure. Electroactive responses of the fiber(s) are monitored.Type: ApplicationFiled: February 10, 2010Publication date: August 12, 2010Applicant: U.S.A. as represented by the Administrator of the National Aeronautics and Sapce AdministrationInventors: Lisa A. Scott-Carnell, Emilie J. Siochi
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Publication number: 20090108503Abstract: A method and system are provided for aligning fibers in an electrospinning process. A jet of a fiberizable material is directed towards an uncharged collector from a dispensing location that is spaced apart from the collector. While the fiberizable material is directed towards the collector, an elliptical electric field is generated via the electrically charged dispenser and an oppositely-charged control location. The field spans between the dispensing location and the control location that is within line-of-sight of the dispensing location, and impinges upon at least a portion of the collector. Various combinations of numbers and geometries of dispensers, collectors, and electrodes can be used.Type: ApplicationFiled: June 2, 2008Publication date: April 30, 2009Applicant: USA as represented by the Administrator of the National Aeronautics and Space AdministrationInventors: Lisa A. Scott-Carnell, Ralph M. Stephens, Nancy M. Holloway, Caroline Rhim, Laura Niklason, Robert L. Clark, Emilie J. Siochi