Patents by Inventor Lisa A. SHEHADEH

Lisa A. SHEHADEH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS EMPLOYING AN OSTEOPONTIN APTAMER TO DELIVER NUCLEIC ACIDS INTO SMOOTH MUSCLE, ENDOTHELIAL, CARDIAC AND PROGENITOR/STEM CELLS
    Publication number: 20160272973
    Abstract: Various therapeutic polynucleotides are provided along with their use to treat a variety of disease states. The chimeric polynucleotides disclosed herein comprise an OPN aptamer linked to an OPN-specific therapeutic oligonucleotide in order to deliver the OPN-specific therapeutic polynucleotide to the site of OPN expression. Thus, the specificity of OPN aptamers allows delivery of therapeutic molecules to the site of unhealthy tissue. Accordingly, the chimeric polynucleotides disclosed herein can reduce at least one symptom of a disease or unhealthy condition by delivering an OPN-specific therapeutic oligonucleotide that interferes with a disease promoting factor.
    Type: Application
    Filed: November 14, 2014
    Publication date: September 22, 2016
    Inventor: Lisa A. SHEHADEH