Patents by Inventor Lisa ALEXANDER

Lisa ALEXANDER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250075233
    Abstract: Described herein are methods, compositions, and systems for multiplex editing using Cas enzymes or editing of T-cells or related cells using Cas enzymes.
    Type: Application
    Filed: September 1, 2023
    Publication date: March 6, 2025
    Inventors: Brian C. THOMAS, Christopher BROWN, Audra DEVOTO, Cristina BUTTERFIELD, Lisa ALEXANDER, Daniela S.A. GOLTSMAN, Greg COST, Rebecca LAMOTHE, Diego ESPINOSA
  • Publication number: 20250059568
    Abstract: Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful for gene editing.
    Type: Application
    Filed: August 27, 2024
    Publication date: February 20, 2025
    Inventors: Brian THOMAS, Christopher BROWN, Audra DEVOTO, Cristina BUTTERFIELD, Lisa ALEXANDER, Daniela S.A. GOLTSMAN, Justine ALBERS, Alan BROOKS, Greg COST, Morayma TEMOCHE-DIAZ, Cindy CASTELLE, Rebecca LAMOTHE
  • Publication number: 20250002881
    Abstract: Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful for gene editing.
    Type: Application
    Filed: March 5, 2024
    Publication date: January 2, 2025
    Inventors: Brian C. THOMAS, Christopher BROWN, Cindy CASTELLE, Lisa ALEXANDER, Liliana GONZALEZ-OSORIO, Paula MATHEUS CARNEVALI, Dom CASTANZO
  • Publication number: 20240409962
    Abstract: The present disclosure provides for endonuclease enzymes as well as methods of using such enzymes or variants thereof.
    Type: Application
    Filed: May 10, 2024
    Publication date: December 12, 2024
    Inventors: Brian C. THOMAS, Christopher BROWN, Audra DEVOTO, Cristina BUTTERFIELD, Lisa ALEXANDER, Daniela S.A. GOLTSMAN
  • Publication number: 20240360477
    Abstract: The present disclosure provides systems and methods for transposing a cargo nucleotide sequence to a target nucleic acid site. These systems and methods may comprise a first double-stranded nucleic acid comprising the cargo nucleotide sequence, wherein the cargo nucleotide sequence is configured to interact with a retrotransposase, and the retrotransposase, wherein said retrotransposase is configured to transpose the cargo nucleotide sequence to the target nucleic acid site.
    Type: Application
    Filed: March 7, 2024
    Publication date: October 31, 2024
    Inventors: Brian C. THOMAS, Christopher BROWN, Daniela S.A. GOLTSMAN, Sarah LAPERRIERE, Cindy CASTELLE, Lisa ALEXANDER, Mary Kaitlyn Chiu, Morayma TEMOCHE-DIAZ, Anu THOMAS
  • Publication number: 20240352433
    Abstract: The present disclosure provides for endonuclease enzymes having HEPN domains, as well as methods of using such enzymes or variants thereof.
    Type: Application
    Filed: April 25, 2024
    Publication date: October 24, 2024
    Inventors: Brian C. THOMAS, Christopher BROWN, Cindy CASTELLE, Lisa ALEXANDER, Liliana GONZALEZ-OSORIO, Morayma TEMOCHE-DIAZ
  • Publication number: 20240344045
    Abstract: The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.
    Type: Application
    Filed: May 20, 2024
    Publication date: October 17, 2024
    Inventors: Brian C. THOMAS, Christopher BROWN, Rose KANTOR, Audra DEVOTO, Cristina BUTTERFIELD, Lisa ALEXANDER, Daniela S.A. GOLTSMAN, Jason LIU
  • Publication number: 20240336905
    Abstract: Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful for gene editing.
    Type: Application
    Filed: March 6, 2024
    Publication date: October 10, 2024
    Inventors: Brian C. THOMAS, Christopher BROWN, Cindy CASTELLE, Lisa ALEXANDER, Liliana GONZALEZ-OSORIO, Paula MATHEUS CARNEVALI, Dom CASTANZO
  • Publication number: 20240327871
    Abstract: The present disclosure provides systems and methods for transposing a cargo nucleotide sequence to a target nucleic acid site. These systems and methods may comprise a first double-stranded nucleic acid comprising the cargo nucleotide sequence, wherein the cargo nucleotide sequence is configured to interact with a transposase, and the transposase, wherein said transposase is configured to transpose the cargo nucleotide sequence to the target nucleic acid site.
    Type: Application
    Filed: March 7, 2024
    Publication date: October 3, 2024
    Inventors: Brian C. THOMAS, Christopher BROWN, Daniela S.A. GOLTSMAN, Lisa ALEXANDER, Sarah LAPERRIERE
  • Publication number: 20240309356
    Abstract: The present disclosure provides for endonuclease enzymes as well as methods of using such enzymes or variants thereof.
    Type: Application
    Filed: February 7, 2024
    Publication date: September 19, 2024
    Inventors: Brian THOMAS, Christopher BROWN, Audra DEVOTO, Cristina BUTTERFIELD, Lisa ALEXANDER, Daniela S.A. GOLTSMAN
  • Publication number: 20240301374
    Abstract: The present disclosure provides systems and methods for transposing a cargo nucleotide sequence to a target nucleic acid site. These systems and methods may comprise a first double-stranded nucleic acid comprising the cargo nucleotide sequence, wherein the cargo nucleotide sequence is configured to interact with a recombinase or transposase complex, a cas effector complex comprising a cas effector and at least one engineered guide polynucleotide configured to hybridize to the target nucleic acid site, and the recombinase or transposase complex wherein said recombinase or transposase complex is configured to recruit the cargo nucleotide to the target nucleic acid site.
    Type: Application
    Filed: October 5, 2023
    Publication date: September 12, 2024
    Inventors: Brian THOMAS, Christopher BROWN, Daniela S.A. GOLTSMAN, Cristina BUTTERFIELD, Lisa ALEXANDER, Jason LIU
  • Publication number: 20240294948
    Abstract: The present disclosure provides for endonuclease enzymes as well as methods of using such enzymes or variants thereof.
    Type: Application
    Filed: May 21, 2024
    Publication date: September 5, 2024
    Inventors: Brian C. THOMAS, Christopher BROWN, Audra DEVOTO, Cristina BUTTERFIELD, Lisa ALEXANDER, Daniela S.A. GOLTSMAN, Rebecca LAMOTHE
  • Publication number: 20240287484
    Abstract: The present disclosure provides systems and methods for transposing a cargo nucleotide sequence to a target nucleic acid site. These systems and methods can comprise a nucleic acid comprising the cargo nucleotide sequence, wherein the cargo nucleotide sequence is configured to interact with a retrotransposase, and the retrotransposase, wherein said retrotransposase is configured to transpose the cargo nucleotide sequence to the target nucleic acid site. The systems and methods can also involve use of functional fragments of retrotransposases.
    Type: Application
    Filed: March 7, 2024
    Publication date: August 29, 2024
    Inventors: Brian C. THOMAS, Christopher BROWN, Daniela S.A. GOLTSMAN, Sarah LAPERRIERE, Cindy CASTELLE, Lisa ALEXANDER, Mary Kaitlyn Chiu, Morayma TEMOCHE-DIAZ, Anu THOMAS
  • Publication number: 20240218339
    Abstract: Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful for gene editing.
    Type: Application
    Filed: November 30, 2023
    Publication date: July 4, 2024
    Inventors: Brian THOMAS, Christopher BROWN, Audra DEVOTO, Cristina BUTTERFIELD, Lisa ALEXANDER, Daniela S.A. GOLTSMAN
  • Publication number: 20240209332
    Abstract: The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.
    Type: Application
    Filed: November 7, 2022
    Publication date: June 27, 2024
    Inventors: Brian THOMAS, Christopher BROWN, Rose KANTOR, Audra DEVOTO, Cristina BUTTERFIELD, Lisa ALEXANDER, Daniela S.A. GOLTSMAN, Jason LIU, Rebecca LAMOTHE, Diego ESPINOSA, Meghan STORLIE, Greg COST
  • Publication number: 20240200047
    Abstract: The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.
    Type: Application
    Filed: February 26, 2024
    Publication date: June 20, 2024
    Inventors: Brian C. THOMAS, Christopher BROWN, Rose KANTOR, Audra DEVOTO, Cristina BUTTERFIELD, Lisa ALEXANDER, Daniela S.A. GOLTSMAN, Jason LIU, Rebecca LAMOTHE, Diego ESPINOSA, Meghan STORLIE, Greg COST
  • Publication number: 20240117330
    Abstract: The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.
    Type: Application
    Filed: June 15, 2023
    Publication date: April 11, 2024
    Inventors: Brian Thomas, Christopher BROWN, Rose KANTOR, Audra DEVOTO, Cristina BUTTERFIELD, Lisa ALEXANDER, Daniela S.A. GOLTSMAN, Jason LIU
  • Publication number: 20240110167
    Abstract: The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.
    Type: Application
    Filed: October 17, 2023
    Publication date: April 4, 2024
    Inventors: Brian C. THOMAS, Christopher BROWN, Daniela S.A. GOLTSMAN, Cristina BUTTERFIELD, Lisa ALEXANDER, Cindy CASTELLE
  • Publication number: 20240093239
    Abstract: Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful for gene editing.
    Type: Application
    Filed: April 18, 2023
    Publication date: March 21, 2024
    Inventors: Brian THOMAS, Christopher BROWN, Audra DEVOTO, Cristina BUTTERFIELD, Lisa ALEXANDER, Daniela S.A. GOLTSMAN, Justine ALBERS, Alan BROOKS, Greg COST, Morayma TEMOCHE-DIAZ, Cindy CASTELLE, Rebecca LAMOTHE
  • Publication number: 20230340481
    Abstract: The present disclosure provides systems and methods for transposing a cargo nucleotide sequence to a target nucleic acid site. These systems and methods may comprise a first double-stranded nucleic acid comprising the cargo nucleotide sequence, wherein the cargo nucleotide sequence is configured to interact with a recombinase complex, a cas effector complex comprising a cas effector and at least one engineered guide polynucleotide configured to hybridize to the target nucleic acid site, and the recombinase complex wherein said recombinase complex is configured to recruit the cargo nucleotide to the target nucleic acid site.
    Type: Application
    Filed: March 22, 2023
    Publication date: October 26, 2023
    Inventors: Brian THOMAS, Christopher BROWN, Daniela S.A. GOLTSMAN, Cristina BUTTERFIELD, Lisa ALEXANDER, Jason LIU