Patents by Inventor Lisa Anne Hasvold

Lisa Anne Hasvold has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparation of chiral 3-amino-pyrrolidine and analogous bicyclic compounds
    Patent number: 5837868
    Abstract: A process for the preparation of chiral 3-aminopyrrolidine and analogous bicyclic derivatives from dihydroxy olefins by treatment with titanium isopropoxide, an optically active tartrate ester and tert-butyl hydroperoxide, followed by subsequent alkylation of the intermediate with an alkyl or alkenyl magnesium halide, then pyrrolidine ring formation by condensation with an arylmethylamine, subsequent chiral replacement of a ring hydroxyl group with an amino group with further protection thereof, optional additional substitution closing of the second ring, and hydrogenolysis to remove a ring-nitrogen protecting group.
    Type: Grant
    Filed: November 19, 1997
    Date of Patent: November 17, 1998
    Assignee: Abbott Laboratories
    Inventors: Wei-Bo Wang, Qun Li, Daniel T. Chu, Lisa Anne Hasvold
  • Process for preparation of chiral 3-amino-pyrrolidine and analogous bicyclic compounds
    Patent number: 5703244
    Abstract: A process for the preparation of chiral 3-aminopyrrolidine and analogous bicyclic derivatives from dihydroxy olefins by treatment with titanium isopropoxide, an optically active tartrate ester and tert-butyl hydroperoxide, followed by subsequent alkylation of the intermediate with an alkyl or alkenyl magnesium halide, then pyrrolidine ring formation by condensation with an arylmethylamine, subsequent chiral replacement of a ring hydroxyl group with an amino group with further protection thereof, optional additional substitution closing of the second ring, and hydrogenolysis to remove a ring-nitrogen protecting group.
    Type: Grant
    Filed: November 21, 1996
    Date of Patent: December 30, 1997
    Assignee: Abbott Laboratories
    Inventors: Qun Li, Wei-Bo Wang, Daniel T. Chu, Lisa Anne Hasvold