Patents by Inventor Lisa Buckley

Lisa Buckley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250099868
    Abstract: The present invention includes a spray drying disposable device for use in a spray drying system. The disposable has a spray drying head and a plasma drying chamber. The head has a spray dry nozzle assembly in fluid communication with the plasma source and the pressurized aerosol gas source. The pressurized gas flows in a vortex pattern that atomizes plasma droplets in the chamber. The head also includes a plenum has uniform air pressure of the drying gas. A baffle plate forms the floor of the plenum having drying gas jets that supply drying gas to the chamber. The atomized plasma droplets evaporate in the presence of the drying gas emitted from the jets to obtain dried plasma particles and humid air. A capture filter captures the dried plasma particles and allows the humid air to pass. The humid air passes through the gas outlet and the exhaust port.
    Type: Application
    Filed: December 9, 2024
    Publication date: March 27, 2025
    Applicant: Velico Medical, Inc.
    Inventors: Richard Meehan, Robert R. Andrews, Herman E. Snyder, William J. Merritt, Evan P. Ordway, Clair Strohl, Mark A. Popovsky, Lisa A. Buckley, Jihae Sohn
  • Publication number: 20250090366
    Abstract: An ostomy bag device includes a bag with first and second chambers communicating via a first opening and a pressure sensitive interface. The bag includes a second opening interfacing with a stoma exit and receiving waste in the first chamber, a third opening expelling the waste from the first chamber, and a fourth opening releasing gas from the second chamber. The interface transitions from a first state in which the interface prevents a gas flow through the first opening from the first to second chambers and a second state in which the interface allows the flow. A first pressure differential in the first chamber relative to the second chamber causes the interface to assume the first state preventing the flow and a second pressure differential in the first chamber relative to the second chamber higher than the first differential causes the interface to assume the second state allowing the flow.
    Type: Application
    Filed: August 12, 2024
    Publication date: March 20, 2025
    Inventors: Colin BUCKLEY, Allison KUMARASENA, Rahul PRABHU, Laura Emily SABBAN, Kurt Nicholas ROBAKIEWICZ, Cristina ROMANY, Lisa Margaret SANGREE, Julia VEITCH
  • Patent number: 12201920
    Abstract: The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the number of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment; and when reconstituted, has reduced complement activation (C5A, C3A).
    Type: Grant
    Filed: January 17, 2023
    Date of Patent: January 21, 2025
    Assignee: Velico Medical, Inc.
    Inventors: Robert R. Andrews, Herman E. Snyder, William J. Merritt, Evan P. Ordway, Clair Strohl, Qiyong Peter Liu, Jihae Sohn, Lisa A. Buckley, Mark A Popovsky
  • Publication number: 20240359113
    Abstract: The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the number of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment; and when reconstituted, has reduced complement activation (C5A, C3A).
    Type: Application
    Filed: March 13, 2024
    Publication date: October 31, 2024
    Applicant: Velico Medical, Inc
    Inventors: Qiyong Peter Liu, Herman E. Snyder, Evan P. Ordway, William J. Merritt, Robert R. Andrews, Clair Strohl, Jihae Sohn, Lisa A. Buckley, Mark A. Popovsky
  • Patent number: 11975274
    Abstract: The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the number of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment; and when reconstituted, has reduced complement activation (C5A, C3A).
    Type: Grant
    Filed: September 15, 2022
    Date of Patent: May 7, 2024
    Assignee: Velico Medical, Inc.
    Inventors: Qiyong Peter Liu, Herman E. Snyder, Kyle D. Erickson, Evan P. Ordway, William J. Merritt, Richard Meehan, Robert R. Andrews, Clair Strohl, Jihae Sohn, Mark A. Popovsky, Lisa A. Buckley
  • Publication number: 20240131063
    Abstract: The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the mean size of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment.
    Type: Application
    Filed: September 14, 2023
    Publication date: April 25, 2024
    Applicant: Velico Medical, Inc.
    Inventors: Jihae Sohn, Lisa A. Buckley, Mark A. Popovsky, Qiyong Peter Liu, Herman E. Snyder, Evan P. Ordway, William J. Merritt, Robert R. Andrews, Clair Strohl
  • Publication number: 20240131062
    Abstract: The spray dried plasma by the nature of its characteristics and the process by which it is made allows for a dried plasma with reduced pathogens. It has at least three aspects of pathogen reduction that results in a plasma product with reduced or no pathogens. The first aspect relates to a spray drying disposable and machine that eliminates or minimizes the introduction of pathogens into the spray drying process and is referred to as the anti-contamination process. The second aspect of pathogen reduction relates to the spray drying process and parameters that reduces pathogens that may be present in the donor plasma, and/or inhibit pathogen growth and/or pathogen proliferation introduced by the donor plasma. The third aspect results in reduced pathogens occurring during storage of the dried plasma wherein the manufacturing and storage conditions are such that pathogens are reduced, and/or pathogen growth and/or pathogen proliferation are inhibited.
    Type: Application
    Filed: September 14, 2023
    Publication date: April 25, 2024
    Applicant: Velico Medical, Inc.
    Inventors: Mark A. Popovsky, Lisa A. Buckley, Jihae Sohn, Evan P. Ordway, Qiyong Peter Liu, Robert R. Andrews, Herman E. Snyder, William J. Merritt, Clair Strohl, Russell J Barron
  • Publication number: 20240091667
    Abstract: A method of treating plasma with a pretreatment solution that has a physiologically compatible spray dry stable acidic substance (SDSAS) and an amino acid, prior to or contemporaneously with spray drying of the plasma that results in greater recovery and greater long-term stabilization of the dried plasma proteins as compared to spray dried plasma that has not be subject to the formulation method of the present invention, as well as compositions related to plasma dried by the methods of the present invention.
    Type: Application
    Filed: September 14, 2023
    Publication date: March 21, 2024
    Applicant: Velico Medical, Inc.
    Inventors: Lisa A. Buckley, Mark A. Popovsky, Jihae Sohn, Qiyong Peter Liu, William J. Merritt
  • Publication number: 20140259724
    Abstract: The inventive device and methods described herein address the introduction of a safe and effective freeze-dried biological product, and particularly a plasma product, to a subject in need thereof. The present invention relates to a multifunctional, staged closure device, which also is described as a lyophilization container for plasma (LCP). The device and methods described herein address how to reproducibly achieve a low moisture and substantially oxygen-free atmosphere within a finally hermetically sealed biocompatible low aspect plastic vessel within a standard shelf-stoppering freeze dryer. The present inventive device and methods provide a freeze-dried plasma product that is fully traceable, preserves the constituent plasma activity, is readily prepared in a sterile fashion, is stable, ensures ease of storage and permits rapid reconstitution and delivery to a patient.
    Type: Application
    Filed: March 13, 2013
    Publication date: September 18, 2014
    Applicant: HemCon Medical Technologies, Inc.
    Inventors: Simon McCarthy, Lisa Buckley, Clint Pepper, Ervelyn Winata, Barry Starkman
  • Patent number: 8449520
    Abstract: A flexible container receives a liquid material, which is freeze-dried in situ within the flexible container. A gas permeable material that is separate from the flexible container provides gas transport for sublimation during drying and lyophilization. The gas permeable portion of the system can be isolated and removed from the flexible container post-lyophilzation The freeze-dried material is stored in the flexible container until administration is necessary. The flexible container receives a reconstituting liquid for mixing with the freeze-dried material, and conveys the reconstituted freeze-dried material from the flexible container for administration to an individual.
    Type: Grant
    Filed: August 15, 2008
    Date of Patent: May 28, 2013
    Assignee: HemCon Medical Technologies Inc.
    Inventors: Clinton B. Pepper, Simon J. McCarthy, Lisa A. Buckley, Eric K. Meyer
  • Publication number: 20110144613
    Abstract: A flexible container receives a liquid material, which is freeze-dried in situ within the flexible container. A gas permeable material that is separate from the flexible container provides gas transport for sublimation during drying and lyophilization. The gas permeable portion of the system can be isolated and removed from the flexible container post-lyophilzation The freeze-dried material is stored in the flexible container until administration is necessary. The flexible container receives a reconstituting liquid for mixing with the freeze-dried material, and conveys the reconstituted freeze-dried material from the flexible container for administration to an individual.
    Type: Application
    Filed: August 11, 2009
    Publication date: June 16, 2011
    Applicant: HEMCON MEDICAL TECHNOLOGIES, INC.
    Inventors: Clinton B. Pepper, Simon J. McCarthy, Lisa A. Buckley, Eric K. Meyer
  • Publication number: 20090223080
    Abstract: A method for preparing and a system containing freeze-dried plasma that will be reconstituted. Ascorbic acid is incorporated into the freeze-dried plasma prior to the plasma being reconstituted.
    Type: Application
    Filed: February 13, 2009
    Publication date: September 10, 2009
    Inventors: Simon J. McCarthy, Lisa A. Buckley
  • Publication number: 20090113753
    Abstract: A flexible container receives a liquid material, which is freeze-dried in situ within the flexible container. A gas permeable material that is separate from the flexible container provides gas transport for sublimation during drying and lyophilization. The gas permeable portion of the system can be isolated and removed from the flexible container post-lyophilzation The freeze-dried material is stored in the flexible container until administration is necessary. The flexible container receives a reconstituting liquid for mixing with the freeze-dried material, and conveys the reconstituted freeze-dried material from the flexible container for administration to an individual.
    Type: Application
    Filed: August 15, 2008
    Publication date: May 7, 2009
    Inventors: Clinton B. Pepper, Simon J. McCarthy, Lisa A. Buckley, Eric K. Meyer
  • Publication number: 20080234654
    Abstract: A vessel receives a liquid material, which is freeze-dried in situ within the vessel. A gas permeable material carried by the vessel provides gas transport for sublimation during drying. After freeze drying, an oxygen-free inert gas is introduced into the vessel through the gas permeable material, to occupy the interior of the vessel with the freeze-dried material. The gas permeable material is covered, to trap the oxygen-free inert gas within the vessel with the freeze-dried material. The freeze-dried material is stored in the entrapped oxygen-free inert gas within the vessel for a storage period. The vessel receives a reconstituting liquid for mixing with the freeze-dried material, and conveys the reconstituted freeze-dried material from the vessel for administration to an individual.
    Type: Application
    Filed: March 19, 2008
    Publication date: September 25, 2008
    Inventors: Simon J. McCarthy, William D. Block, John W. Morgan, Lisa A. Buckley, Lance D. Hopman, Clinton B. Pepper
  • Patent number: 7322932
    Abstract: A bioprosthetic valve graft comprises a valve frame and valve flaps, the latter acting to open or close a valve aperture to directionally control fluid flow through the bioprosthesis. The bioprosthetic valve graft comprises method for suturelessly attaching a biomaterial suturelessly bonded to the A method for securing a biomaterial to a valve frame includes positioning a flexible valve frame defining an open area on a first major surface of a biomaterial sheet having a peripheral edge, wherein positioning serves to approximate the valve frame and the peripheral edge of the biomaterial sheet to form an at least first bonding locus; and suturelessly bonding the biomaterial to the valve frame at the at least first bonding locus. The method avoids the disadvantages associated with conventional sutures and substantially reduces medical complications in implantations.
    Type: Grant
    Filed: February 2, 2004
    Date of Patent: January 29, 2008
    Assignee: Providence Health System - Oregon
    Inventors: Hua Xie, Lisa A. Buckley
  • Patent number: 7166124
    Abstract: A bioprosthetic stent graft is disclosed, having a stent frame and a biomaterial sheath suturelessly bonded to the stent frame. Sutureless bonding avoids sutures and substantially reducing medical complications in implantation of the stent graft. A device and method for manufacturing the stent graft further is disclosed. A mandrel is employed for shaping the stent graft, and means for irradiating the biomaterial effects sutureless bonding.
    Type: Grant
    Filed: March 21, 2002
    Date of Patent: January 23, 2007
    Assignee: Providence Health System - Oregon
    Inventors: Hua Xie, Lisa A. Buckley
  • Patent number: 7163556
    Abstract: A bioprosthetic valve graft comprises a valve frame and valve flaps, the latter acting to open or close a valve aperture to directionally control fluid flow through the bioprosthesis. The bioprosthetic valve graft comprises a biomaterial suturelessly bonded to the valve frame, avoiding sutures and substantially reducing medical complications in implantations.
    Type: Grant
    Filed: March 21, 2002
    Date of Patent: January 16, 2007
    Assignee: Providence Health System - Oregon
    Inventors: Hua Xie, Lisa A. Buckley
  • Publication number: 20050021136
    Abstract: A bioprosthetic valve graft comprises a valve frame and valve flaps, the latter acting to open or close a valve aperture to directionally control fluid flow through the bioprosthesis. The bioprosthetic valve graft comprises method for suturelessly attaching a biomaterial suturelessly bonded to the A method for securing a biomaterial to a valve frame includes positioning a flexible valve frame defining an open area on a first major surface of a biomaterial sheet having a peripheral edge, wherein positioning serves to approximate the valve frame and the peripheral edge of the biomaterial sheet to form an at least first bonding locus: and suturelessly bonding the biomaterial to the valve frame at the at least first bonding locus. The method avoids the disadvantages associated with conventional sutures and substantially reduces medical complications in implantations.
    Type: Application
    Filed: February 2, 2004
    Publication date: January 27, 2005
    Inventors: Hua Xie, Lisa Buckley
  • Publication number: 20030181968
    Abstract: A bioprosthetic stent graft is disclosed, having a stent frame and a biomaterial sheath suturelessly bonded to the stent frame. Sutureless bonding avoids sutures and substantially reducing medical complications in implantation of the stent graft.
    Type: Application
    Filed: March 21, 2002
    Publication date: September 25, 2003
    Inventors: Hua Xie, Lisa A. Buckley
  • Publication number: 20030181974
    Abstract: A bioprosthetic valve graft comprises a valve frame and valve flaps, the latter acting to open or close a valve aperture to directionally control fluid flow through the bioprosthesis. The bioprosthetic valve graft comprises a biomaterial suturelessly bonded to the valve frame, avoiding sutures and substantially reducing medical complications in implantations.
    Type: Application
    Filed: March 21, 2002
    Publication date: September 25, 2003
    Inventors: Hua Xie, Lisa A. Buckley