Abstract: The present disclosure provides a new bra assembly that allows for the fashionable fit of two or more bra sized wearers in a single bra sized garment. The present disclosure also provides for a bra assembly that enables wearers with different cup sizes, as well as many different underband sizes, to comfortable fit into the same bra sized garment.

Abstract: Methods for detecting a prostate cancer in a subject comprise detecting a marker selected from an endosomal associated marker and/or a lysosomal associated marker from the subject.

Abstract: Methods for detecting a prostate cancer in a subject comprise detecting a marker selected from an endosomal associated marker and/or a lysosomal associated marker from the subject.

Abstract: The present disclosure provides a new bra assembly that allows for the fashionable fit of two or more bra sized wearers in a single bra sized garment. The present disclosure also provides for a bra assembly that enables wearers with different cup sizes, as well as many different underband sizes, to comfortable fit into the same bra sized garment.

Abstract: Methods for detecting a prostate cancer in a subject comprise detecting a marker selected from an endosomal associated marker and/or a lysosomal associated marker from the subject.

Abstract: A garment includes a body of fabric forming a garment body and a waistband connected to the garment body. The waistband has a first edge that is also connected to the garment body and a second edge opposite to the first edge. The waistband has a first layer of material and a second layer of material that are connected both at the first edge and the second edge and a waistband depth defined by the distance between the first edge and the second edge. The waistband has a pocket that is further formed by a third and/or fourth layer of material. The pocket has an opening that accesses a space inside the pocket and a pocket depth between the opening and the first edge, and the pocket obfuscates the contents therein.

Abstract: The present disclosure relates to methods for detecting a prostate cancer. Certain embodiments of the present disclosure provide a method of detecting a prostate cancer in a subject, the method comprising detecting a marker selected from an endosomal associated marker and/or a lysosomal associated marker from the subject.

Abstract: The present invention provides a homogeneous assay for identifying an antibody producing cell producing an antibody which binds to a selected antigen comprising: a) providing a population of antibody producing cells; b) incubating said population of antibody producing cells with a selected antigen and a labeled anti-antibody antibody, wherein said anti-antibody antibody is capable of distinguishing cells producing an antibody which binds to the selected antigen from those cells which do not; and c) identifying an antibody producing cell capable of producing an antibody which binds to the selected antigen.

Abstract: The present invention provides a homogeneous assay for identifying an antibody producing cell producing an antibody which binds to a selected antigen comprising: a) providing a population of antibody producing cells; b) incubating said population of antibody producing cells with a selected antigen and a labeled anti-antibody antibody, wherein said anti-antibody antibody is capable of distinguishing cells producing an antibody which binds to the selected antigen from those cells which do not; and c) identifying an antibody producing cell capable of producing an antibody which binds to the selected antigen.

Abstract: The present invention provides a novel method for treating and/or preventing thioredoxin (TRX)-mediated diseases and conditions, by administering to a subject in need of such treatment a therapeutically effective amount of a histone deacetylase (HDAC) inhibitor or a pharmaceutically acceptable salt or hydrate thereof. The HDAC inhibitor can alter the expression of a thioredoxin-binding-protein (e.g. TBP-2), which in turn can lead to an altered TRX/thioredoxin-binding-protein cellular binding interaction, resulting in an increase or decrease in the level or activity of cellular TRX, for example the expression level or reducing activity of TRX. Thus the present invention relates to the use of HDAC inhibitors in a method of preventing and/or treating a wide variety of thioredoxin (TRX)-mediated diseases and conditions, such as inflammatory diseases, allergic diseases, autoimmune diseases, diseases associated with oxidative stress or diseases characterized by cellular hyperproliferation.

Abstract: The present invention provides a novel method for treating and/or preventing thioredoxin (TRX)-mediated diseases and conditions, by administering to a subject in need of such treatment a therapeutically effective amount of a histone deacetylase (HDAC) inhibitor or a pharmaceutically acceptable salt or hydrate thereof. The HDAC inhibitor can alter the expression of a thioredoxin-binding-protein (e.g. TBP-2), which in turn can lead to an altered TRX/thioredoxin-binding-protein cellular binding interaction, resulting in an increase or decrease in the level or activity of cellular TRX, for example the expression level or reducing activity of TRX. Thus the present invention relates to the use of HDAC inhibitors in a method of preventing and/or treating a wide variety of thioredoxin (TRX)-mediated diseases and conditions, such as inflammatory diseases, allergic diseases, autoimmune diseases, diseases associated with oxidative stress or diseases characterized by cellular hyperproliferation.

Abstract: The present invention leverages a data gathering service to provide information regarding a network system's health, performance and/or utilization via a computing entity, local and/or remote. This provides an optimized means to aggregate a single network's data and/or multiple networks' data, decreasing the amount of effort required by system administrators to keep a network operational and/or to provide control of its utilization and/or update a system's state. In one instance of the present invention, a data gathering service aggregates data from systems and provides access to this information via a communication means. In another instance of the present invention, aggregated data is utilized to provide manual and/or automatic control of one or more aspects of a system's utilization by an entity and/or a person. In yet another instance of the present invention, aggregated utilization data is employed to provide a management/productivity tool for end-users of a networked system.

Abstract: The present invention leverages a data gathering service to provide information regarding a system's health state via a computing entity, local and/or remote. This provides an optimized means to aggregate a single network's data and/or multiple networks' data, decreasing the amount of effort required by system administrators to manage health related alerts. In one instance of the present invention, a data gathering service aggregates health data from systems and provides access to this information via a communication means. In another instance of the present invention, aggregated, averaged data is utilized to provide manual and/or automatic control and/or management facilitation of health monitoring related tasks.

Abstract: The present invention leverages a data gathering service to provide information regarding a network system's health, performance and/or utilization via a computing entity, local and/or remote. This provides an optimized means to aggregate a single network's data and/or multiple networks' data, decreasing the amount of effort required by system administrators to keep a network operational and/or to provide control of its utilization and/or update a system's state. In one instance of the present invention, a data gathering service aggregates data from systems and provides access to this information via a communication means. In another instance of the present invention, aggregated data is utilized to provide manual and/or automatic control of one or more aspects of a system's utilization and/or state by an entity and/or a person.