Patents by Inventor Lisa C. McConlogue

Lisa C. McConlogue has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Monitoring APP cleavage in transgenic rodents comprising an APP Swedish mutation
    Patent number: 7608749
    Abstract: The invention provides transgenic non-human animals and transgenic non-human mammalian cells harboring a transgene encoding an APP polypeptide comprising the Swedish mutation.
    Type: Grant
    Filed: December 20, 2006
    Date of Patent: October 27, 2009
    Assignees: Elan Pharmaceuticals, Inc., Eli Lilly and Company
    Inventors: Lisa C. McConlogue, Jun Zhao, Sukanto Sinha
  • Testing compounds for effects on synaptophysin in transgenic mice expressing an Alzheimer's disease FAD DNA sequence
    Patent number: 7186881
    Abstract: The construction of transgenic animal models of human Alzheimer's disease, and methods of using the models to screen potential Alzhe## disease therapeutics, are described. The models are characterized by pathologies similar to pathologies observed in Alzheimer's disease, based on expression of all three forms of the ?-amyloid precursor protein (APP), APP695, APP751, and APP770, as well as various point mutations based on naturally occurring mutations, such as the London and Indiana familial Alzheimer's disease (FAD) mutations at amino acid 717, predicted mutations in the APP gene, and truncated forms of APP that contain the A? region. Animal cells can be isolated from the transgenic animals or prepared using the same constructs with standard techniques such as lipofection or electroporation.
    Type: Grant
    Filed: December 23, 2003
    Date of Patent: March 6, 2007
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Kate Dora Games, Dale B. Schenk, Lisa C. McConlogue, Peter A. Seubert, Russell E. Rydel
  • Monitoring APP cleavage in transgenic rodents comprising an APP-Swedish mutation
    Patent number: 7179953
    Abstract: The invention provides transgenic non-human animals and transgenic non-human mammalian cells harboring a transgene encoding an APP polypeptide comprising the Swedish mutation.
    Type: Grant
    Filed: June 27, 2003
    Date of Patent: February 20, 2007
    Assignees: Elan Pharmaceuticals, Inc., Eli Lilly and Company
    Inventors: Lisa C. McConlogue, Jun Zhao, Sukanto Sinha
  • Screening markers and methods for neurodegenerative disorders
    Publication number: 20040213739
    Abstract: The invention includes identification of specific markers, the elevation of which in central nervous tissue is associated with Alzheimer's Disease. The invention also includes improved assay methods for selecting compounds useful in reducing or preventing onset of the pathology associated with Alzheimer's Disease.
    Type: Application
    Filed: October 14, 2003
    Publication date: October 28, 2004
    Applicant: Elan Pharmaceuticals, Inc.
    Inventors: Lisa C. McConlogue, Elizabeth Messersmith, Frederique Bard
  • Selecting compounds to reduce inflammation associated with Alzheimer's disease
    Patent number: 6664442
    Abstract: The invention includes identification of specific markers, the elevation of which in central nervous tissue is associated with Alzheimer's Disease. The invention also includes improved assay methods for selecting compounds useful in reducing or preventing onset of the pathology associated with Alzheimer's Disease.
    Type: Grant
    Filed: March 30, 2001
    Date of Patent: December 16, 2003
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Lisa C. McConlogue, Kate D. Games, Theodore A. Yednock, Tan Hua, Elizabeth Messersmith, Frederique Bard
  • Screening markers and methods for neurodegenerative disorders
    Publication number: 20020147998
    Abstract: The invention includes identification of specific markers, the elevation of which in central nervous tissue is associated with Alzheimer's Disease. The invention also includes improved assay methods for selecting compounds useful in reducing or preventing onset of the pathology associated with Alzheimer's Disease.
    Type: Application
    Filed: March 30, 2001
    Publication date: October 10, 2002
    Inventors: Lisa C. McConlogue, Kate D. Games, Theodore A. Yednock, Tan Hua, Elizabeth Messersmith, Frederique Bard
  • Transgenic animals harboring APP allele having swedish mutation
    Patent number: 5612486
    Abstract: The invention provides transgenic non-human animals and transgenic non-human mammalian cells harboring a transgene encoding an APP polypeptide comprising the Swedish mutation.
    Type: Grant
    Filed: November 1, 1993
    Date of Patent: March 18, 1997
    Assignees: Athena Neurosciences, Inc., Eli Lilly and Company
    Inventors: Lisa C. McConlogue, Jun Zhao
  • Methods of screening for .beta.-amyloid peptide production inhibitors
    Patent number: 5604102
    Abstract: Processing of .beta.-amyloid precursor protein (.beta.APP) is monitored by detecting the secretion of a soluble amino-terminal fragment or .beta.APP (ATF-.beta.APP) resulting from cleavage of .beta.APP at the amino-terminus of .beta.-amyloid peptide. Secretion of ATF-.beta.APP in animal models may be monitored to identify inhibitors of .beta.-amyloid production. The ATF-.beta.APP may be detected using antibodies and other specific binding substances which recognize a carboxy terminal residue on the fragment. Animals expressing the Swedish mutation of .beta.APP are described which produce abundant amounts of ATF-.beta.APP.
    Type: Grant
    Filed: October 27, 1993
    Date of Patent: February 18, 1997
    Assignee: Athena Neurosciences, Inc.
    Inventors: Lisa C. McConlogue, Dale B. Schenk, Peter A. Seubert, Sukanto Sinha, Jun Zhao