Abstract: The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.

Abstract: Systems and methods for monitoring, communicating and safeguarding the health and alertness of a pilot during operation of an aircraft. The state of the pilot is monitored using biometric sensors. A pilot state data processor of an onboard computer system determines whether the value of any health/alertness parameter has exceeded a specified threshold or not. The onboard computer system further includes an automatic control processor that automatically transfers control authority from the pilot to the autopilot and then issues an unfit pilot alert. Then a real-time audio/video/data connection is established between the pilot onboard the aircraft and a remote medical professional. The remote medical professional evaluates the medical fitness of the pilot and determines whether the pilot automated mitigations should be continued (pilot unfit for duty) or removed (pilot fit for duty).

Abstract: A method, system, and computer program product are provided to automatically assess a plurality of fatigue mitigation strategies. In the context of a method, fatigue information is received for a subject and determination is made as to whether the subject is fatigued. In an instance in which the subject is fatigued, the method determines an estimated effectiveness of each of a plurality of fatigue mitigation strategies based upon fatigue information for the subject and one or more constraints and characteristics of a respective fatigue mitigation strategy. The determination of the estimated effectiveness of each of the plurality of fatigue mitigation strategies may also be based upon at least one of a time to become effective, a duration of the effectiveness and a side effect. The method also identifies at least one fatigue mitigation strategy to address fatigue of the subject.

Abstract: A system for delivering oxygen enriched air to a selected location on an aircraft may include: a gas separation system configured to output a flow of the oxygen enriched air; an environmental control system configured to output a flow of conditioned air; and/or first, second, and third ducts. The first duct may be configured to direct the flow of the oxygen enriched air to the third duct. The second duct may be configured to direct the flow of the conditioned air to the third duct. The conditioned air and the oxygen enriched air may be mixed in the third duct. The third duct may be configured to direct the mixed conditioned and oxygen enriched air to at least one dispensing station at the selected location that is configured to dispense the mixed conditioned and oxygen enriched air to users of the at least one dispensing station.

Abstract: An improved aircraft management system for consolidating and prioritizing alerts through the use of an alert consolidator is described herein. According to an embodiment, a method for providing a list of tasks for responding to alerts provided by an aircraft sensing system includes receiving a plurality of alerts provided by an aircraft sensing system prioritizing at least two alerts, generating a prioritized sequential list of tasks for responding to the prioritized alerts, and providing, in a single format, the prioritized sequential list of tasks.

Abstract: A touch screen bezel design that is optimized for use by a pilot during in-flight operations, which include vibrations, turbulence, and other factors affecting direct interaction with a touch screen. The bezel is further designed to include bezel indices which support touch interaction by a finger when a pilot's arm is near full extension as well as in other suboptimal postures. The bezel is also designed to elicit understanding that the screen it surrounds is touch-enabled, providing a common interface look and feel for all touch-enabled screens on the flight deck.

Abstract: A system, method, and computer program product for detecting, in real time, a fatigue level of a vehicle operator. Multiple physiological indicators of an individual vehicle operator can be monitored at different instances when the operator's level of fatigue is known and can be quantified. A statistical model of the vehicle operator's fatigue can be developed from the data from the multiple instances. In future instances, the statistical model can be applied to real-time physiological data collected from the operator during operation of the vehicle to determine a fatigue level. A warning can be provided when the statistically-calculated fatigue level exceeds a threshold level.

Abstract: An improved aircraft management system for consolidating and prioritizing alerts through the use of an alert consolidator is described herein. According to an embodiment, a method for providing a list of tasks for responding to alerts provided by an aircraft sensing system includes receiving a plurality of alerts provided by an aircraft sensing system prioritizing at least two alerts, generating a prioritized sequential list of tasks for responding to the prioritized alerts, and providing, in a single format, the prioritized sequential list of tasks.

Abstract: A touch screen bezel design that is optimized for use by a pilot during in-flight operations, which include vibrations, turbulence, and other factors affecting direct interaction with a touch screen. The bezel is further designed to include bezel indices which support touch interaction by a finger when a pilot's arm is near full extension as well as in other suboptimal postures. The bezel is also designed to elicit understanding that the screen it surrounds is touch-enabled, providing a common interface look and feel for all touch-enabled screens on the flight deck.

Abstract: A system and method for a customized ambient lighting environment for individuals in vehicles travelling rapidly across multiple time zones, that can be automated and/or based on user input and which allows each user to be exposed to light in accordance to selected preferences and circumstances, in order to begin acclimating the user to a new time zone, or avoid acclimating to a new time zone, and/or otherwise mitigate circadian desynchrony.

Abstract: A system and method for a customized ambient lighting environment for individuals in vehicles travelling rapidly across multiple time zones, that can be automated and/or based on user input and which allows each user to be exposed to light in accordance to selected preferences and circumstances, in order to begin acclimating the user to a new time zone, or avoid acclimating to a new time zone, and/or otherwise mitigate circadian desynchrony.

Abstract: A system, method, and computer program product for detecting, in real time, a fatigue level of a vehicle operator. Multiple physiological indicators of an individual vehicle operator can be monitored at different instances when the operator's level of fatigue is known and can be quantified. A statistical model of the vehicle operator's fatigue can be developed from the data from the multiple instances. In future instances, the statistical model can be applied to real-time physiological data collected from the operator during operation of the vehicle to determine a fatigue level. A warning can be provided when the statistically-calculated fatigue level exceeds a threshold level.

Abstract: A method and apparatus for electronic checklist display system. A checklist display device is connected to a number of display screens. A display screen within the number of display screens displays an integrated electronic checklist within a checklist display window on the display screen. The integrated electronic checklist comprises a number of checklist items associated with a vehicle system, systems information for the vehicle system, and graphics representing a current status of a number of components of the vehicle system.

Abstract: A system directing oxygen enriched air to locations on an aircraft. A nitrogen generating system may be configured for generating nitrogen enriched air and oxygen enriched air.

Abstract: A system for providing an oxygen enriched localized environment in a user compartment on an aircraft that can include a gas separation system having an oxygen output channel that outputs a flow of oxygen enriched air, and a duct network coupled to the oxygen output channel and to direct the flow of oxygen enriched air to the user compartment, localized volume.

Abstract: A method, system, and computer program product are provided to automatically assess a plurality of fatigue mitigation strategies. In the context of a method, fatigue information is received for a subject and determination is made as to whether the subject is fatigued. In an instance in which the subject is fatigued, the method determines an estimated effectiveness of each of a plurality of fatigue mitigation strategies based upon fatigue information for the subject and one or more constraints and characteristics of a respective fatigue mitigation strategy. The determination of the estimated effectiveness of each of the plurality of fatigue mitigation strategies may also be based upon at least one of a time to become effective, a duration of the effectiveness and a side effect. The method also identifies at least one fatigue mitigation strategy to address fatigue of the subject.

Abstract: A method and apparatus for electronic checklist display system. A checklist display device is connected to a number of display screens. A display screen within the number of display screens displays an integrated electronic checklist within a checklist display window on the display screen. The integrated electronic checklist comprises a number of checklist items associated with a vehicle system, systems information for the vehicle system, and graphics representing a current status of a number of components of the vehicle system.