Abstract: Methods and materials for identifying and treating mammals (e.g., humans) having multiple myeloma (MM) are provided herein. For example, this document provides methods and materials that can be used to identify and treat mammals having advanced stage MM, and/or having MVI that is resistant to treatment with immunomodulatory drugs (IMiDs) and/or proteasome inhibitors (PIs).

Abstract: The disclosed systems and methods provide patient care unit (PCU) order confirmation. A method may include authorizing a user to operate a medication delivery device. The method may also include retrieving, in response to the authorizing, a user history associated with the user, wherein the user history includes one or more dispensing records for pending medications. The method may also include determining, based on a context that includes the user history, one or more medication order candidates for present administration. The method may also include presenting a user interface for confirming a medication order from the one or more medication order candidates. The method may also include configuring at least one parameter of the medication delivery device based on the confirmed medication order received from the user interface.

Abstract: Programmable guide RNAs (gRNAs) play a central role in the CRISPR revolution sweeping biology and medicine by directing the function of a Cas protein effector to a target gene of choice. To achieve programmable control over regulatory scope, the activity of a conditional guide RNA (cgRNA) depends on the presence or absence of an RNA trigger, allowing for cell-selective regulation of CRISPR/Cas function. Unlike a standard gRNA, a cgRNA is programmable at multiple levels, with the target-binding sequence controlling the target of Cas activity (edit, silence, induce, or bind a gene of choice) and the triggerbinding sequence controlling the scope of Cas activity. cgRNA mechanisms that are allosteric allow for independent design of the target and trigger sequences, providing the flexibility to select the regulatory target and scope independently.

Abstract: Small molecule inhibitors that block the interaction between B-cell lymphoma 10 protein (BCL10) and mucosa- associated lymphoid tissue lymphoma translocation protein 1 (MALT1), thereby inhibiting both the protease and scaffolding activities of MALT1, and MALT1- dependent downstream signaling, including IL-6 and IL-10 secretion by B-cell lymphoma cells and IL-2 transcription and secretion by Jurkat T cells.

Abstract: A display system for sensing a finger of a user applied to the display system includes a display panel; a sensor for sensing the finger; a sensing light source configured to emit a first light having a first wavelength W1; and a reflective polarizer disposed between the display panel and the sensor. For a substantially normally incident light, an optical transmittance of the reflective polarizer versus wavelength for a first polarization state has a band edge such that for a first wavelength range extending from a smaller wavelength L1 to a greater wavelength L2 and including W1, where 30 nm?L2?L1?50 nm and L1 is greater than and within about 20 nm of a wavelength L3 corresponding to an optical transmittance of about 50% along the band edge, the optical transmittance has an average of greater than about 75%.

Abstract: In various embodiments, a washable mat system comprises a top cover removably attached to a bottom pad. The top cover comprises layers of material, including a top layer with a tufted loop pile, a water-resistant internal layer, and a bottom knit surface. The top cover is sufficiently malleable to be folded, rolled, compressed, and withstand multiple wash and dry cycles while maintaining material stability. The bottom pad also comprises layers of material, including a top layer to removably attach to the bottom knit surface of the top cover, an internal cushioning layer, and a non-slip bottom surface.

Abstract: Agricultural compositions are provided that include at least one keratin protein and at least one carrier. The agricultural compositions provide an environmentally friendly and biodegradable alternative to traditional chemicals and biologicals. The agricultural compositions are suitable for a variety of uses including, but not limited to, increasing plant height and biomass, increasing plant, leaf, increasing stem and root weight, and increasing crop or plant yield compared to application of traditional chemicals or plant growth regulators.

Abstract: It is herewith provided a biocontrol composition comprising an intact minicell comprising a nucleic acid that targets a transcript encoding a polypeptide and a method for controlling pests and pathogens with novel systems and compositions to deliver RNA molecules to a subject.

Abstract: Apparatuses, systems and methods associated with substrate assemblies for computer devices are disclosed herein. In embodiments, a core for a substrate assembly includes a first metal region, a second metal region, and a dielectric region located between the first metal region and the second metal region. The dielectric region includes one or more fibers, wherein each of the one or more fibers includes aluminum, boron, silicon, or oxide. Other embodiments may be described and/or claimed.

Abstract: Aspects of the present disclosure are directed to pressure sensing. As may be implemented in accordance with one or more embodiments, an external energy field is applied to a resonant circuit having inductive conductors separated by a compressible dielectric, for wirelessly detecting pressure. Specifically, the resonant circuit is responsive to the energy field and applied pressures by operating in respective states exhibiting different resonant frequencies that are based upon pressure-related compression of the compressible dielectric. These resonant frequencies, or a change in the resonant frequencies, can be used as an indication of the pressure.

Abstract: The present invention is directed to compounds of Formula (I), and to salts thereof, their synthesis, and their use as PI3-K? inhibitors and/or PI3-K?/mTOR dual inhibitors.

Abstract: A method for manufacturing a coloring agent for keratin fibers from a first composition A and a second composition B is provided. The method comprises directing the first composition A from a container A by a filler apparatus through an inlet opening into a second container B containing the second composition B. In container B, as a result of the introduction of composition A and/or the action of the filler apparatus, at least one exit opening is formed out of which the coloring agent for keratin fibers exits from container B as a mixture of compositions A and B.

Abstract: The present invention is directed to compounds of Formula (I), and to salts thereof, their synthesis, and their use as PI3-K? inhibitors and/or PI3-K?/mTOR dual inhibitors.

Abstract: Provided is a composition comprising an aromatic material selected from a polythiol aromatic compound or resin, a hydroxythiophenol compound or resin, a catechol novolak resin, a catechol cresol novolak resin, a polyhydroxy aromatic resin or compound comprising at least one aromatic ring having at least one hydroxyl group attached directly to the aromatic ring wherein at least one hydroxyl group is a phenolate salt, or a combination thereof, and a salt former compound capable of forming a salt with the aromatic material, a fluoropolymer, and optionally a phase transfer catalyst. Also provided are articles comprising powder-coated fluoropolymers with aromatic compounds, and methods for making the compositions and articles.