Abstract: A system may include at least one medical device and a processing system. The medical device may be configured to treat a condition by delivering a therapy to a patient. The therapy is at least partially defined using a parameter set. The processing system may be configured for use to acquire clinical effect data (CED) for the condition, acquire a medication state of medication administered to treat the condition, adjust the CED based on the medication state to provide medication-adjusted CED, and identify an adjusted parameter set for the at least one medical device to deliver the therapy based on the medication-adjusted CED. The adjusted parameter set may be communicated to a clinician (or patient or other user) as a suggestion or may be automatically implemented to update the therapy.

Abstract: Systems and techniques are disclosed to process freeform data relating to neurostimulation treatment of a human patient, to determine relevant attributes and information regarding a state of the patient. In an example, a system to process freeform data implements electronic operations to: obtain freeform input that indicates characteristics of a neurostimulation treatment of a human patient; validate the freeform input; identify attributes associated with a state of the human patient, based on words from the validated freeform input; associate the attributes with the validated freeform input; and store data for the validated freeform input and the associated attributes. Specific operations for validating may include excluding or replacing words, and specific operations for identifying attributes may be based on natural language processing. Such processing of the freeform data may be used to identify results of neurostimulation programs, and effect improvements to neurostimulation programming or usage.

Abstract: A system may include a first device and a second device. The first device may be configured to send advertising packets with a request to communicate with the second device, and the second device may be configured to discover the first device and initiate a wireless communication session with the first device using the advertising packets. The first device may be configured to send advertising packets and send a request to communicate with the second device, and the second device may be configured to discover the first device and initiate a wireless communication session with the first device using the advertising packets.

Abstract: A method for programming an electrical stimulation system including at least one implantable electrical stimulation lead including a plurality of electrodes that includes receiving a target and a location of the at least one implantable electrical stimulation lead; receiving at least one stimulation criterion; for each of the at least one stimulation criterion, identifying one or more values of a cost parameter that meet the stimulation criterion, wherein the cost parameter includes a ratio of a cost of stimulating at least one defined region of tissue over a benefit of stimulating a region of the target; and providing at least one of the one or more values of the cost parameter that meet the at least one stimulation criterion to a user or the electrical stimulation system to assist in programming the electrical stimulation system.

Abstract: Electrical stimulation systems and methods for operation of the electrical stimulation system are described. The method includes directing electrical stimulation through the electrodes of the lead and monitoring movements of a hand positioned over an implantation site of an implantable control module of the electrical stimulation system using an accelerometer coupled to a processor of the implantable control module. Another method includes detecting, by a sensor, a plurality of taps of a body region of a patient over an implantation site of the implantable control module, identifying, by the processor of the implantable control module, an indicator, trigger, or marker based on the detected tapping, and performing an activity corresponding to the identified indicator, trigger, or marker.

Abstract: Systems and methods for presenting electrostimulation data and patient clinical responses to electrostimulation are disclosed. A system comprises an implantable stimulator, and a programming device including a controller to identify first and second sets of base stimulation settings each comprising an electrode configuration and stimulation parameter values selected from a configuration and parameter search space. The controller can detect clinical effects and evaluate a clinical response indicator in response to electrostimulation for each base stimulation setting of the first set, and predict clinical effects and estimate a clinical response indicator without delivering electrostimulation for each base stimulation setting of the second set. Based on the clinical response indicators, the controller can determine characteristic stimulation amplitudes for one or more electrode configurations. A formatted monopolar review report comprising the characteristic stimulation amplitudes can be displayed to the user.

Abstract: Systems and methods for creating, maintaining, and remotely modifying stimulation settings for a neuromodulation therapy are discussed. An exemplary system includes an implantable stimulator to provide electrostimulation via a lead comprising a plurality of electrodes, and a programming device. The programming device identifies a search space of electrode configurations and parameter values for the lead, and determines, based on a clinical response indicator under a first patient state, at least one base stimulation setting including an optimal electrode configuration and an optimal stimulation parameter value from the identified search space. The system includes a remotely controlled therapy titration device that can modify the base stimulation setting under a second patient state based on an evaluation of a modified clinical response indicator. The modified base stimulation setting may be stored in the memory, or used by the implantable stimulator to deliver electrostimulation.

Abstract: Systems and methods for reducing neurostimulation electrode configuration and parameter search space and controlling electrostimulation are discussed. An exemplary system includes an implantable stimulator to provide electrostimulation via a lead comprising a plurality of electrodes, and a programming device. The programing device receives electrode position information relative to an anatomical region of interest or physiological signals respectively sensed by the plurality of electrodes, and identifies a search space of electrode configurations and parameter values for the lead with respect to the neural target. The programing device can determine a target stimulation setting based on a clinical response to electrostimulation delivered using electrodes and stimulation parameter values from the identified search space, and generate a control signal to the control the implantable stimulator to deliver electrostimulation in accordance with the target stimulation setting.