Abstract: A rotary union for use along an incompressible fluid path between a rotating machine component and a non-rotating machine component includes a non-rotating seal carrier including a non-rotating seal element, which together with the non-rotating seal carrier define a net hydraulic surface on an internal side and a net pneumatic surface on an external side. Contact of an incompressible fluid under pressure with the net hydraulic surface creates a closing force, and contact of a compressible fluid under pressure with the net pneumatic surface creates an opening force.

Abstract: A rotary union includes a housing having a shaft rotatably mounted in a bore. A plurality of annular plates is mounted on the shaft in spaced relation, and a plurality of spools is disposed in alternating fashion between the plurality of annular plates on the shaft. Each spool includes two seal rings creating mechanical face seals with adjacent annular plates. The shaft, the plurality of annular plates and the plurality of spools are arranged to assemble in a stacked arrangement, which is insertable as a whole into the cylindrical bore of the housing.

Abstract: A rotary union for use along an incompressible fluid path between a rotating machine component and a non-rotating machine component includes a non-rotating seal carrier including a non-rotating seal element, which together with the non-rotating seal carrier define a net hydraulic surface on an internal side and a net pneumatic surface on an external side. Contact of an incompressible fluid under pressure with the net hydraulic surface creates a closing force, and contact of a compressible fluid under pressure with the net pneumatic surface creates an opening force.

Abstract: A rotary union includes a housing having a shaft rotatably mounted in a bore. A plurality of annular plates is mounted on the shaft in spaced relation, and a plurality of spools is disposed in alternating fashion between the plurality of annular plates on the shaft. Each spool includes two seal rings creating mechanical face seals with adjacent annular plates. The shaft, the plurality of annular plates and the plurality of spools are arranged to assemble in a stacked arrangement, which is insertable as a whole into the cylindrical bore of the housing.

Abstract: The present invention provides new methods for the in vitro preparation of bioartificial tissue equivalents and their enhanced integration after implantation in vivo. These methods include submitting a tissue construct to a biomimetic electrical stimulation during cultivation in vitro to improve its structural and functional properties, and/or in vivo, after implantation of the construct, to enhance its integration with host tissue and increase cell survival and functionality. The inventive methods are particularly useful for the production of bioartificial equivalents and/or the repair and replacement of native tissues that contain electrically excitable cells and are subject to electrical stimulation in vivo, such as, for example, cardiac muscle tissue, striated skeletal muscle tissue, smooth muscle tissue, bone, vasculature, and nerve tissue.

Abstract: The present invention provides new methods for the in vitro preparation of bioartificial tissue equivalents and their enhanced integration after implantation in vivo. These methods include submitting a tissue construct to a biomimetic electrical stimulation during cultivation in vitro to improve its structural and functional properties, and/or in vivo, after implantation of the construct, to enhance its integration with host tissue and increase cell survival and functionality. The inventive methods are particularly useful for the production of bioartificial equivalents and/or the repair and replacement of native tissues that contain electrically excitable cells and are subject to electrical stimulation in vivo, such as, for example, cardiac muscle tissue, striated skeletal muscle tissue, smooth muscle tissue, bone, vasculature, and nerve tissue.

Abstract: Compositions and methods comprising at least one active agent chosen from TGF-P superfamily proteins, including BMPs, and GDFs for increasing the growth rate or modulating the development of engineered cartilage are disclosed. The compositions are useful in the treatment of osteoarthritis, cartilage defects, and in related tissue repair.