Patents by Inventor Lisa G. Shaffer
Lisa G. Shaffer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8954337Abstract: Disclosed is an interactive genome browser executing within a web browser application, configured to display patient genetic data and additional genetic data tracks which are aligned by base pair. Additional tracks may include public data, community data, private data, sequence gaps, and additional genetic tests or probes which are available. Tests or probes may be ordered by selecting them from a test or probe track. Data in a genetic information database may also be searched using the interactive genome browser. Analyzed patient data may be published and made available to a community of users, which may communicate with one another.Type: GrantFiled: November 6, 2009Date of Patent: February 10, 2015Assignee: Signature GenomicInventors: Brice Tebbs, Blake C. Ballif, Bassem A. Bejjani, Lisa G. Shaffer
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Patent number: 8924228Abstract: Disclosed is an interactive genome browser executing within a web browser application, configured to display patient genetic data and additional genetic data tracks which are aligned by base pair. Additional tracks may include public data, community data, private data, sequence gaps, and additional genetic tests or probes which are available. Tests or probes may be ordered by selecting them from a test or probe track. Data in a genetic information database may also be searched using the interactive genome browser. Analyzed patient data may be published and made available to a community of users, which may communicate with one another.Type: GrantFiled: November 6, 2009Date of Patent: December 30, 2014Assignee: Signature GenomicInventors: Brice Tebbs, Blake C. Ballif, Bassem A. Bejjani, Lisa G. Shaffer
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Patent number: 8731956Abstract: Techniques for allowing doctors and clinicians to upload genetic data associated with patients for comparison with previously-uploaded genetic data associated with other patients are described herein. These techniques may also allow doctors and clinicians to create notations associated with uploaded patient data. Both the previously-uploaded data as well as the created notations may be used by doctors and clinicians in attempting to diagnosis patients. That is, these techniques allow previously-acquired knowledge to be widely shared for the future benefit in attempting to detect genetic syndromes.Type: GrantFiled: November 5, 2008Date of Patent: May 20, 2014Assignee: Signature Genomic LaboratoriesInventors: Bassem A. Bejjani, Lisa G. Shaffer, Blake Ballif, Brice Tebbs, Kyle Sundin
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Patent number: 7910353Abstract: Methods and apparatuses for selecting and arranging clinically relevant chromosomal loci allow an exemplary diagnostic array to simultaneously test for numerous genetic alterations that occur in many different parts of the human genome. Clinically irrelevant or ineffective loci are eliminated. One implementation increases reliability and accuracy by dividing the base-pair sequence of each chromosomal locus into segments and then assigning nucleic acid clones for comparative genomic hybridization to each different segment. The segments may overlap for increased resolution and control. Clones representing segments that are adjacent on a native chromosome are placed in non-adjacent target areas of the array to avoid interfering hybridization reactions. Arrangement motifs within an array may be redundantly repeated for high availability and increased reliability and accuracy of results. Techniques, hardware, software, logic engines, loci collections, and diagnostic arrays are described.Type: GrantFiled: February 11, 2005Date of Patent: March 22, 2011Assignee: Signature Genomic LaboratoriesInventors: Lisa G. Shaffer, Bassem A. Bejjani
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Publication number: 20100286994Abstract: Disclosed is an interactive genome browser executing within a web browser application, configured to display patient genetic data and additional genetic data tracks which are aligned by base pair. Additional tracks may include public data, community data, private data, sequence gaps, and additional genetic tests or probes which are available. Tests or probes may be ordered by selecting them from a test or probe track. Data in a genetic information database may also be searched using the interactive genome browser. Analyzed patient data may be published and made available to a community of users, which may communicate with one another.Type: ApplicationFiled: November 6, 2009Publication date: November 11, 2010Applicant: Signature Genomic LabsInventors: Brice Tebbs, Blake C. Ballif, Bassem A. Bejjani, Lisa G. Shaffer
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Publication number: 20100281401Abstract: Disclosed is an interactive genome browser executing within a web browser application, configured to display patient genetic data and additional genetic data tracks which are aligned by base pair. Additional tracks may include public data, community data, private data, sequence gaps, and additional genetic tests or probes which are available. Tests or probes may be ordered by selecting them from a test or probe track. Data in a genetic information database may also be searched using the interactive genome browser. Analyzed patient data may be published and made available to a community of users, which may communicate with one another.Type: ApplicationFiled: November 6, 2009Publication date: November 4, 2010Applicant: Signature Genomic LabsInventors: Brice Tebbs, Blake C. Ballif, Bassem A. Bejjani, Lisa G. Shaffer
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Patent number: 7816123Abstract: Methods and apparatuses for selecting and arranging clinically relevant chromosomal loci allow an exemplary diagnostic array to simultaneously test for numerous genetic alterations that occur in many different parts of the human genome. Clinically irrelevant or ineffective loci are eliminated. One implementation increases reliability and accuracy by dividing the base-pair sequence of each chromosomal locus into segments and then assigning nucleic acid clones for comparative genomic hybridization to each different segment. The segments may overlap for increased resolution and control. Clones representing segments that are adjacent on a native chromosome are placed in non-adjacent target areas of the array to avoid interfering hybridization reactions. Arrangement motifs within an array may be redundantly repeated for high availability and increased reliability and accuracy of results. Techniques, hardware, software, logic engines, loci collections, and diagnostic arrays are described.Type: GrantFiled: February 11, 2005Date of Patent: October 19, 2010Assignee: Signature Genomics-Perkin ElmerInventors: Lisa G. Shaffer, Bassem A. Bejjani
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Publication number: 20100248984Abstract: Methods and apparatuses for selecting and arranging clinically relevant chromosomal loci allow an exemplary diagnostic array to simultaneously test for numerous genetic alterations that occur in many different parts of the human genome. Clinically irrelevant or ineffective loci are eliminated. One implementation increases reliability and accuracy by dividing the base-pair sequence of each chromosomal locus into segments and then assigning nucleic acid clones for comparative genomic hybridization to each different segment. The segments may overlap for increased resolution and control. Clones representing segments that are adjacent on a native chromosome are placed in non-adjacent target areas of the array to avoid interfering hybridization reactions. Arrangement motifs within an array may be redundantly repeated for high availability and increased reliability and accuracy of results. Techniques, hardware, software, logic engines, loci collections, and diagnostic arrays are described.Type: ApplicationFiled: June 10, 2010Publication date: September 30, 2010Applicant: SIGNATURE GENOMICS LABORATORYInventors: Lisa G. Shaffer, Bassem A. Bejjani
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Publication number: 20100248983Abstract: Methods and apparatuses for selecting and arranging clinically relevant chromosomal loci allow an exemplary diagnostic array to simultaneously test for numerous genetic alterations that occur in many different parts of the human genome. Clinically irrelevant or ineffective loci are eliminated. One implementation increases reliability and accuracy by dividing the base-pair sequence of each chromosomal locus into segments and then assigning nucleic acid clones for comparative genomic hybridization to each different segment. The segments may overlap for increased resolution and control. Clones representing segments that are adjacent on a native chromosome are placed in non-adjacent target areas of the array to avoid interfering hybridization reactions. Arrangement motifs within an array may be redundantly repeated for high availability and increased reliability and accuracy of results. Techniques, hardware, software, logic engines, loci collections, and diagnostic arrays are described.Type: ApplicationFiled: June 10, 2010Publication date: September 30, 2010Applicant: SIGNATURE GENOMICS LABORATORYInventors: Lisa G. Shaffer, Bassem A. Bejjani
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Publication number: 20100248992Abstract: Methods and apparatuses for selecting and arranging clinically relevant chromosomal loci allow an exemplary diagnostic array to simultaneously test for numerous genetic alterations that occur in many different parts of the human genome. Clinically irrelevant or ineffective loci are eliminated. One implementation increases reliability and accuracy by dividing the base-pair sequence of each chromosomal locus into segments and then assigning nucleic acid clones for comparative genomic hybridization to each different segment. The segments may overlap for increased resolution and control. Clones representing segments that are adjacent on a native chromosome are placed in non-adjacent target areas of the array to avoid interfering hybridization reactions. Arrangement motifs within an array may be redundantly repeated for high availability and increased reliability and accuracy of results. Techniques, hardware, software, logic engines, loci collections, and diagnostic arrays are described.Type: ApplicationFiled: June 10, 2010Publication date: September 30, 2010Applicant: SIGNATURE GENOMICS LABORATORY LLCInventors: Lisa G. Shaffer, Bassem A. Bejjani
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Publication number: 20100248985Abstract: Methods and apparatuses for selecting and arranging clinically relevant chromosomal loci allow an exemplary diagnostic array to simultaneously test for numerous genetic alterations that occur in many different parts of the human genome. Clinically irrelevant or ineffective loci are eliminated. One implementation increases reliability and accuracy by dividing the base-pair sequence of each chromosomal locus into segments and then assigning nucleic acid clones for comparative genomic hybridization to each different segment. The segments may overlap for increased resolution and control. Clones representing segments that are adjacent on a native chromosome are placed in non-adjacent target areas of the array to avoid interfering hybridization reactions. Arrangement motifs within an array may be redundantly repeated for high availability and increased reliability and accuracy of results. Techniques, hardware, software, logic engines, loci collections, and diagnostic arrays are described.Type: ApplicationFiled: June 10, 2010Publication date: September 30, 2010Applicant: SIGNATURE GENOMICS LABORATORY LLCInventors: Lisa G. Shaffer, Bassem A. Bejjani
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Publication number: 20100167953Abstract: Control nucleic acids and their method of use to simultaneously test for numerous genetic alterations that involve an unbalanced arrangement of chromosomes. One implementation increases reliability and accuracy by adding additional nucleic acid to test and/or reference samples. Clones representing segments insensitive to chromosomal rearrangements are placed in non-adjacent target areas of a microarray to avoid interfering hybridization reactions.Type: ApplicationFiled: March 9, 2010Publication date: July 1, 2010Inventors: Blake C. Ballif, Lisa G. Shaffer, Bassem A. Bejjani
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Publication number: 20100115421Abstract: Techniques for allowing doctors and clinicians to upload genetic data associated with patients for comparison with previously-uploaded genetic data associated with other patients are described herein. These techniques may also allow doctors and clinicians to create notations associated with uploaded patient data. Both the previously-uploaded data as well as the created notations may be used by doctors and clinicians in attempting to diagnosis patients. That is, these techniques allow previously-acquired knowledge to be widely shared for the future benefit in attempting to detect genetic syndromes.Type: ApplicationFiled: November 5, 2008Publication date: May 6, 2010Applicant: Signature Genomic LabsInventors: Bassem A. Bejjani, Lisa G. Shaffer, Blake Ballif, Brice Tebbs, Kyle Sundin
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Publication number: 20090075835Abstract: Methods for diagnosing the presence or absence of a genetic disorder in a patient are provided, wherein the genetic disorder is associated with a chromosomal abnormality at 1q41q42 and/or 16p11.2p12.2, and wherein the genetic disorder is not Fryns syndrome or congenital diaphragmatic hernia (CDH). Materials, such as microarrays for use in microarray CGH, and kits for use in such methods are also provided.Type: ApplicationFiled: September 16, 2008Publication date: March 19, 2009Applicant: SIGNATURE GENOMICS LABORATORIES, LLCInventors: Bassem A. Bejjani, Blake Charles Ballif, Lisa G. Shaffer
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Publication number: 20070238121Abstract: Control nucleic acids and their method of use to simultaneously test for numerous genetic alterations that involve an unbalanced arrangement of chromosomes. One implementation increases reliability and accuracy by adding additional nucleic acid to test and/or reference samples. Clones representing segments insensitive to chromosomal rearrangements are placed in non-adjacent target areas of a microarray to avoid interfering hybridization reactions.Type: ApplicationFiled: March 30, 2007Publication date: October 11, 2007Inventors: Blake C. Ballif, Lisa G. Shaffer, Bassem A. Bejjani