Abstract: Methods of modeling the in vivo efficacy of drug combinations for the treatment or prevention of viral infection are described. The described methods combine data for single drugs and drug combinations from pharmacokinetic, pharmacodynamic, and viral dynamics models under a series of estimated in vivo drug potencies to provide predictions of the in vivo effects of the drug combinations. These predictions can be used to more accurately select drugs and drug treatment regimens that can be successful in controlling viral infection in animal studies, clinical trials and in medical or veterinary interventions. Also described is a method of treating or preventing filovirus infections using combinations of orally available drugs based on predictions from the modeling methods.

Abstract: A sleeve protector is formed of a tube of polymeric material with an elastic insert at the wrist end for tightly surrounding the wrist. The tube is slit more than halfway axially, and a flap of material is extended over the slit so that it overlies material at the opposite side of the slit. Two pairs of complementary Velcro fasteners attach the overlapping flap to the material adjacent the slit. One fastener at the elbow end is elongated to allow circumferential size adjustment. The slit and flap extend more than halfway along the tube and preferably about 3/5 of the way along the tube, to provide easy insertion of a hand and sleeve within the tube and to ensure that a sleeve does not bunch up as the arm is being pushed into the tube and to ensure that the sleeve is covered by the tubular protector.