Patents by Inventor Lisa Joy McCawley

Lisa Joy McCawley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Integrated organ-on-chip systems and applications of the same
    Patent number: 10444223
    Abstract: A microclinical analyzer usable for analysis of one or more bio-objects, each bio-object including an organ or a group of cells includes a fluidic network having a plurality of fluidic switches, a plurality of fluidic paths in fluid communication with the plurality of fluidic switches, and one or more on-chip pumps coupled to corresponding fluidic paths; a sensor array coupled to the fluidic network; and a microcontroller for individually controlling the plurality of fluidic switches and the one or more on-chip pumps of the fluidic network as so to operably and selectively deliver an effluent of at least one bio-object to the sensor array for detecting properties of the effluent, or to a predetermined outlet destination.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: October 15, 2019
    Assignee: VANDERBILT UNIVERSITY
    Inventors: John P. Wikswo, David E. Cliffel, Dmitry A. Markov, John A. McLean, Lisa Joy McCawley, Phillip C. Samson, Ronald S. Reiserer, Frank Emmanuel Block, Jennifer Robin McKenzie
  • INTEGRATED ORGAN-ON-CHIP SYSTEMS AND APPLICATIONS OF THE SAME
    Publication number: 20190064144
    Abstract: A microclinical analyzer usable for analysis of one or more bio-objects, each bio-object including an organ or a group of cells includes a fluidic network having a plurality of fluidic switches, a plurality of fluidic paths in fluid communication with the plurality of fluidic switches, and one or more on-chip pumps coupled to corresponding fluidic paths; a sensor array coupled to the fluidic network; and a microcontroller for individually controlling the plurality of fluidic switches and the one or more on-chip pumps of the fluidic network as so to operably and selectively deliver an effluent of at least one bio-object to the sensor array for detecting properties of the effluent, or to a predetermined outlet destination.
    Type: Application
    Filed: July 30, 2018
    Publication date: February 28, 2019
    Inventors: John P. Wikswo, David E. Cliffel, Dmitry A. Markov, John A. McLean, Lisa Joy McCawley, Phillip C. Samson, Ronald S. Reiserer, Frank Emmanuel Block, Jennifer Robin McKenzie
  • Integrated organ-on-chip systems and applications of the same
    Patent number: 10078075
    Abstract: In one aspect of the invention, an integrated bio-object microfluidics chip includes a fluidic network having a plurality of inlets for providing a plurality of fluids, a plurality of outlets, a bio-object chamber for accommodating at least one bio-object, a plurality of fluidic switches, and one or more pumps, coupled to each other such that at least one fluidic switch operably and selectively receives one fluid from a corresponding inlet and routes the received fluid, through the one or more pumps, to the bio-object chamber so as to perfuse the at least one bio-object therein, and one of the downstream fluidic switches selectively delivers an effluent of the at least one bio-object responsive to the perfusion to a predetermined outlet destination, or to the at least one fluidic switch for recirculation.
    Type: Grant
    Filed: December 10, 2012
    Date of Patent: September 18, 2018
    Assignee: VANDERBILT UNIVERSITY
    Inventors: John P. Wikswo, David E. Cliffel, Dmitry A. Markov, John A. McLean, Lisa Joy McCawley, Phillip C. Samson, Ronald S. Reiserer, Frank Emmanuel Block, Jennifer Robin McKenzie
  • Integrated human organ-on-chip microphysiological systems
    Patent number: 9725687
    Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.
    Type: Grant
    Filed: December 10, 2012
    Date of Patent: August 8, 2017
    Assignees: PRESIDENT AND FELLOWS OF HARVARD COLLEGE, VANDERBILT UNIVERSITY
    Inventors: John P. Wikswo, Philip C. Samson, Frank Emmanuel Block, III, Ronald S. Reiserer, Kevin Kit Parker, John A. McLean, Lisa Joy McCawley, Dmitry Markov, Daniel Levner, Donald E. Ingber, Geraldine A. Hamilton, Josue A. Goss, Robert Cunningham, David E. Cliffel, Jennifer Robin McKenzie, Anthony Bahinski, Christopher David Hinojosa
  • INTEGRATED HUMAN ORGAN-ON-CHIP MICROPHYSIOLOGICAL SYSTEMS
    Publication number: 20150004077
    Abstract: The invention provides integrated Organ-on-Chip microphysiological systems representations of living Organs and support structures for such microphysiological systems.
    Type: Application
    Filed: December 10, 2012
    Publication date: January 1, 2015
    Inventors: John P. Wikswo, Philip C. Samson, Frank Emmanuel Block, III, Ronald S. Reiserer, Kevin Kit Parker, John A. McLean, Lisa Joy McCawley, Dmitry Markov, Daniel Levner, Donald E. Ingber, Geraldine A. Hamilton, Josue A. Goss, Robert Cunningham, David E. Cliffel, Jennifer Robin McKenzie, Anthony Bahinski, Christopher David Hinojosa
  • INTEGRATED ORGAN-ON-CHIP SYSTEMS AND APPLICATIONS OF THE SAME
    Publication number: 20140356849
    Abstract: In one aspect of the invention, an integrated bio-object microfluidics chip includes a fluidic network having a plurality of inlets for providing a plurality of fluids, a plurality of outlets, a bio-object chamber for accommodating at least one bio-object, a plurality of fluidic switches, and one or more pumps, coupled to each other such that at least one fluidic switch operably and selectively receives one fluid from a corresponding inlet and routes the received fluid, through the one or more pumps, to the bio-object chamber so as to perfuse the at least one bio-object therein, and one of the downstream fluidic switches selectively delivers an effluent of the at least one bio-object responsive to the perfusion to a predetermined outlet destination, or to the at least one fluidic switch for recirculation.
    Type: Application
    Filed: December 10, 2012
    Publication date: December 4, 2014
    Inventors: John P. Wikswo, David E. Cliffel, Dmitry A. Markov, John A. McLean, Lisa Joy McCawley, Phillip C. Samson, Ronald S. Reiserer, Frank Emmanuel Block, Jennifer Robin McKenzie