Patents by Inventor Lisa M. Larkin
Lisa M. Larkin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11944532Abstract: The present disclosure relates to tissue engineering, and more particularly to a method for treating or repairing rotator cuff or other tendon tears or damage using scaffold-free, 3-dimensional engineered tendon constructs.Type: GrantFiled: December 7, 2022Date of Patent: April 2, 2024Assignee: The Regents of the University of MichiganInventors: Lisa M. Larkin, Ellen M. Arruda, Michael Smietana, Asheesh Bedi, Stoyna Novakova
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Patent number: 11898132Abstract: A bioreactor and method of forming complex three-dimensional tissue constructs in a single culture chamber. The bioreactor and methods may be used to form multi-phasic tissue constructs having tissue formed from multiple cell types in a single culture chamber. The bioreactor includes at least one translation mechanism to facilitate translation of one or more tissue constructs without direct user intervention, thereby providing a closed, sterile environment for complex tissue fabrication. The bioreactor may be used as a stand-alone device or as part of a large-scale system including many bioreactors. The large-scale system may include a perfusion system to monitor and regulate the tissue culture environment.Type: GrantFiled: July 20, 2021Date of Patent: February 13, 2024Assignee: The Regents of the University of MichiganInventors: Lisa M. Larkin, Ellen M. Arruda, Michael J. Smietana, Pablo Moncada-Larrotiz
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Publication number: 20230101406Abstract: The present disclosure relates to tissue engineering, and more particularly to a method for treating or repairing rotator cuff or other tendon tears or damage using scaffold-free, 3-dimensional engineered tendon constructs.Type: ApplicationFiled: December 7, 2022Publication date: March 30, 2023Inventors: Lisa M. Larkin, Ellen M. Arruda, Michael Smietana, Asheesh Bedi, Stoyna Novakova
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Patent number: 11547551Abstract: The present disclosure relates to tissue engineering, and more particularly to a method for treating or repairing rotator cuff or other tendon tears or damage using scaffold-free 3-dimensional engineered tendon constructs.Type: GrantFiled: March 2, 2017Date of Patent: January 10, 2023Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Lisa M. Larkin, Ellen M. Arruda, Michael Smietana, Asheesh Bedi, Stoyna Novakova
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Publication number: 20220243156Abstract: A bioreactor capable of producing complex, three-dimensional tissue constructs has improved media transfer and increased controllability with regard to exposure to the external environment. The bioreactor includes an external surface, a first tissue culture side for culturing a first cell source in a first tissue culture support region, a second tissue culture side for culturing a second cell source in a second tissue culture support region, and a plurality of ports. At least one of the ports of the plurality of ports extend from the first tissue culture support region of the first tissue culture side to the external surface. The plurality of ports can include an external port that is configured to be a liquid inlet when the bioreactor is in a first orientation and a gas outlet when the bioreactor is in a second orientation.Type: ApplicationFiled: May 24, 2020Publication date: August 4, 2022Inventors: LISA M. LARKIN, ELLEN M. ARRUDA, MICHAEL J. SMIETANA, PABLO MONCADO-LARROTIZ, HALEY TITINGER
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Publication number: 20210348105Abstract: A bioreactor and method of forming complex three-dimensional tissue constructs in a single culture chamber. The bioreactor and methods may be used to form multi-phasic tissue constructs having tissue formed from multiple cell types in a single culture chamber. The bioreactor includes at least one translation mechanism to facilitate translation of one or more tissue constructs without direct user intervention, thereby providing a closed, sterile environment for complex tissue fabrication. The bioreactor may be used as a stand-alone device or as part of a large-scale system including many bioreactors. The large-scale system may include a perfusion system to monitor and regulate the tissue culture environment.Type: ApplicationFiled: July 20, 2021Publication date: November 11, 2021Inventors: Lisa M. LARKIN, Ellen M. ARRUDA, Michael J. SMIETANA, Pablo MONCADA-LARROTIZ
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Patent number: 11078454Abstract: A bioreactor and method of forming complex three-dimensional tissue constructs in a single culture chamber. The bioreactor and methods may be used to form multi-phasic tissue constructs having tissue formed from multiple cell types in a single culture chamber. The bioreactor includes at least one translation mechanism to facilitate translation of one or more tissue constructs without direct user intervention, thereby providing a closed, sterile environment for complex tissue fabrication. The bioreactor may be used as a stand-alone device or as part of a large-scale system including many bioreactors. The large-scale system may include a perfusion system to monitor and regulate the tissue culture environment.Type: GrantFiled: November 21, 2018Date of Patent: August 3, 2021Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Lisa M. Larkin, Ellen M. Arruda, Michael J. Smietana, Pablo Moncada-Larrotiz
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Publication number: 20190153375Abstract: A bioreactor and method of forming complex three-dimensional tissue constructs in a single culture chamber. The bioreactor and methods may be used to form multi-phasic tissue constructs having tissue formed from multiple cell types in a single culture chamber. The bioreactor includes at least one translation mechanism to facilitate translation of one or more tissue constructs without direct user intervention, thereby providing a closed, sterile environment for complex tissue fabrication. The bioreactor may be used as a stand-alone device or as part of a large-scale system including many bioreactors. The large-scale system may include a perfusion system to monitor and regulate the tissue culture environment.Type: ApplicationFiled: November 21, 2018Publication date: May 23, 2019Inventors: Lisa M. LARKIN, Ellen M. ARRUDA, Michael J. SMIETANA, Pablo MONCADA-LARROTIZ
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Publication number: 20190091007Abstract: The present disclosure relates to tissue engineering, and more particularly to a method for treating or repairing rotator cuff or other tendon tears or damage using scaffold-free 3-dimensional engineered tendon constructs.Type: ApplicationFiled: March 2, 2017Publication date: March 28, 2019Inventors: Lisa M. Larkin, Ellen M. Arruda, Michael Smietana, Asheesh Bedi, Stoyna Novakova
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Patent number: 10167444Abstract: A bioreactor and method of forming complex three-dimensional tissue constructs in a single culture chamber. The bioreactor and methods may be used to form multi-phasic tissue constructs having tissue formed from multiple cell types in a single culture chamber. The bioreactor includes at least one translation mechanism to facilitate translation of one or more tissue constructs without direct user intervention, thereby providing a closed, sterile environment for complex tissue fabrication. The bioreactor may be used as a stand-alone device or as part of a large-scale system including many bioreactors. The large-scale system may include a perfusion system to monitor and regulate the tissue culture environment.Type: GrantFiled: July 15, 2016Date of Patent: January 1, 2019Assignee: The Regents of The University of MichiganInventors: Lisa M. Larkin, Ellen M. Arruda, Michael J. Smietana, Pablo Moncada-Larrotiz
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Patent number: 9592255Abstract: The invention relates to scaffold-free three dimensional nerve fibroblast constructs and method of generating the nerve fibroblast constructs. The invention also relates to methods or repairing nerve transection and replacing damaged nerve tissue using the nerve fibroblast constructs of the invention.Type: GrantFiled: July 1, 2011Date of Patent: March 14, 2017Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Lisa M. Larkin, Ellen M. Arruda, Jennifer Baltich, Aaron Adams, Leah Hatch-Vallier
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Publication number: 20170037354Abstract: A bioreactor and method of forming complex three-dimensional tissue constructs in a single culture chamber. The bioreactor and methods may be used to form multi-phasic tissue constructs having tissue formed from multiple cell types in a single culture chamber. The bioreactor includes at least one translation mechanism to facilitate translation of one or more tissue constructs without direct user intervention, thereby providing a closed, sterile environment for complex tissue fabrication. The bioreactor may be used as a stand-alone device or as part of a large-scale system including many bioreactors. The large-scale system may include a perfusion system to monitor and regulate the tissue culture environment.Type: ApplicationFiled: July 15, 2016Publication date: February 9, 2017Inventors: Lisa M. LARKIN, Ellen M. ARRUDA, Michael J. SMIETANA, Pablo MONCADA-LARROTIZ
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Patent number: 9259510Abstract: A system and method for forming a bone construct include providing bone marrow stromal cells on a substrate without disposing the cells within an exogenous scaffold, and culturing the cells in vitro in osteogenic media such that the cells form a confluent monolayer and detach from the substrate to form a self-organized three-dimensional bone construct. A system and method for forming a ligament construct using fibrogenic media and a system and method for forming a functionally integrated bone-ligament construct are also provided.Type: GrantFiled: May 1, 2014Date of Patent: February 16, 2016Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Ellen M. Arruda, Lisa M. Larkin, Fatima N. Syed-Picard, Michael Smietana, Jinjin Ma
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Publication number: 20140243979Abstract: A system and method for forming a bone construct include providing bone marrow stromal cells on a substrate without disposing the cells within an exogenous scaffold, and culturing the cells in vitro in osteogenic media such that the cells form a confluent monolayer and detach from the substrate to form a self-organized three-dimensional bone construct. A system and method for forming a ligament construct using fibrogenic media and a system and method for forming a functionally integrated bone-ligament construct are also provided.Type: ApplicationFiled: May 1, 2014Publication date: August 28, 2014Applicant: The Regents of the University of MichiganInventors: Ellen M. Arruda, Lisa M. Larkin, Fatima N. Syed-Picard, Michael Smietana, Jinjin Ma
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Patent number: 8764828Abstract: A system and method for forming a bone construct include providing bone marrow stromal cells on a substrate without disposing the cells within an exogenous scaffold, and culturing the cells in vitro in osteogenic media such that the cells form a confluent monolayer and detach from the substrate to form a self-organized three-dimensional bone construct. A system and method for forming a ligament construct using fibrogenic media and a system and method for forming a functionally integrated bone-ligament construct are also provided.Type: GrantFiled: February 4, 2008Date of Patent: July 1, 2014Assignee: The Regents of the University of MichiganInventors: Ellen M. Arruda, Lisa M. Larkin, Fatima N. Syed-Picard, Michael Smietana, Jinjin Ma
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Publication number: 20130156742Abstract: The invention relates to scaffold-free three dimensional nerve fibroblast constructs and method of generating the nerve fibroblast constructs. The invention also relates to methods or repairing nerve transection and replacing damaged nerve tissue using the nerve fibroblast constructs of the invention.Type: ApplicationFiled: July 1, 2011Publication date: June 20, 2013Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Lisa M. Larkin, Ellen M. Arruda, Jennifer Baltich, Aaron Adams, Leah Hatch-Vallier
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Patent number: 8097455Abstract: A system and method for forming a skeletal muscle construct include primary muscle cells provided on a substrate without disposing the cells within an exogenous scaffold, the cells cultured in vitro such that the cells form a confluent monolayer; at least two anchors secured to the monolayer in spaced relationship; and at least one secondary tissue, such as neural or tendon tissue, provided in contact with the monolayer such that the monolayer detaches from the substrate and self-organizes to at least partially surround the at least one secondary tissue, thereby forming a three-dimensional skeletal muscle construct having a functional interface with the secondary tissue.Type: GrantFiled: February 4, 2008Date of Patent: January 17, 2012Assignee: The Regents of the University of MichiganInventors: Lisa M. Larkin, Ellen M. Arruda, Sarah Calve, Tatiana Y. Kostriminova
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Publication number: 20080241209Abstract: A system and method for forming a bone construct include providing bone marrow stromal cells on a substrate without disposing the cells within an exogenous scaffold, and culturing the cells in vitro in osteogenic media such that the cells form a confluent monolayer and detach from the substrate to form a self-organized three-dimensional bone construct. A system and method for forming a ligament construct using fibrogenic media and a system and method for forming a functionally integrated bone-ligament construct are also provided.Type: ApplicationFiled: February 4, 2008Publication date: October 2, 2008Applicant: The Regents of the University of MichiganInventors: Ellen M. Arruda, Lisa M. Larkin, Fatima N. Syed-Picard, Michael Smietana, Jinjin Ma
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Publication number: 20080193910Abstract: A system and method for forming a skeletal muscle construct include primary muscle cells provided on a substrate without disposing the cells within an exogenous scaffold, the cells cultured in vitro such that the cells form a confluent monolayer; at least two anchors secured to the monolayer in spaced relationship; and at least one secondary tissue, such as neural or tendon tissue, provided in contact with the monolayer such that the monolayer detaches from the substrate and self-organizes to at least partially surround the at least one secondary tissue, thereby forming a three-dimensional skeletal muscle construct having a functional interface with the secondary tissue.Type: ApplicationFiled: February 4, 2008Publication date: August 14, 2008Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Lisa M. Larkin, Ellen M. Arruda, Sarah Calve, Tatiana Y. Kostriminova