Patents by Inventor Lisa M. Newman

Lisa M. Newman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polynucleotides encoding beta-glucosidase variants
    Patent number: 8993277
    Abstract: The present invention provides compositions and methods for the expression of recombinant ?-glucosidase variants, as well as their use in the production of fermentable sugars from cellulosic biomass.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: March 31, 2015
    Assignee: Codexis, Inc.
    Inventors: Dipnath Baidyaroy, Louis Clark, Lisa M. Newman
  • Ketoreductases and uses thereof
    Patent number: 8980605
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: March 17, 2015
    Assignee: Codexis, Inc.
    Inventors: Charlene Ching, John M. Gruber, Gjalt W. Huisman, Emily Mundorff, Lisa M. Newman
  • ?-Glucosidase variants
    Patent number: 8772010
    Abstract: The invention relates to recombinantly produced ?-Glucosidase Variants with enhanced thermoactivity compared to naturally occurring proteins. The invention also provides methods for producing a variant ?-glucosidase polypeptide with improved thermoactivity by identifying performance sensitive positions in a target ?-glucosidase polypeptide and substituting the residue at that position with a thermoactivity enhancing residue.
    Type: Grant
    Filed: June 16, 2010
    Date of Patent: July 8, 2014
    Assignee: Codexis, Inc.
    Inventors: Xiyun Zhang, Jie Yang, Dipnath Baidyaroy, Sally Rhiannon Postlethwaite, Attila Andor, Louis Clark, Lisa M. Newman
  • Beta-glucosidase variant enzymes and related polynucleotides
    Patent number: 8715996
    Abstract: The invention provides variants of the Thermoanaerobacter brockii CglT beta-glucosidase that have improve beta-glucosidase activity compared to the wild type enzyme. The invention also provides polynucleotides that encode the variants, as well as methods of producing the variants, enzyme compositions comprising the variants, and methods for using the variants in industrial applications.
    Type: Grant
    Filed: February 26, 2010
    Date of Patent: May 6, 2014
    Assignee: Codexis, Inc.
    Inventors: Dipnath Baidyaroy, Louis Clark, Lisa M. Newman, Charlene Ching
  • RECOMBINANT THERMOASCUS AURANTIACUS BETA-GLUCOSIDASE VARIANTS FOR PRODUCTION OF FERMENTABLE SUGARS FROM CELLULOSIC BIOMASS
    Publication number: 20140113352
    Abstract: The present invention provides compositions and methods for the expression of recombinant ?-glucosidase variants, as well as their use in the production of fermentable sugars from cellulosic biomass.
    Type: Application
    Filed: December 19, 2013
    Publication date: April 24, 2014
    Applicant: Codexis, Inc.
    Inventors: Dipnath Baidyaroy, Louis Clark, Lisa M. Newman
  • Recombinant ?-glucosidase variants
    Patent number: 8652813
    Abstract: The present invention provides compositions and methods for the expression of recombinant ?-glucosidase variants, as well as their use in the production of fermentable sugars from cellulosic biomass.
    Type: Grant
    Filed: November 19, 2010
    Date of Patent: February 18, 2014
    Assignee: Codexis, Inc.
    Inventors: Dipnath Baidyaroy, Louis Clark, Lisa M. Newman
  • Biocatalytic processes for the preparation of stereomerically pure fused bicyclic proline compounds
    Patent number: 8574876
    Abstract: The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M?, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: November 5, 2013
    Assignee: Codexis, Inc.
    Inventors: Benjamin Mijts, Sheela Muley, Jack Liang, Lisa M. Newman, Xiyun Zhang, James Lalonde, Michael D. Clay, Jun Zhu, John M. Gruber, Jeffrey Colbeck, John D. Munger, Jr., Jagadeesh Mavinahalli, Roger Sheldon
  • Halohydrin dehalogenases and related polynucleotides
    Patent number: 8535910
    Abstract: The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.
    Type: Grant
    Filed: January 12, 2012
    Date of Patent: September 17, 2013
    Assignee: Codexis, Inc.
    Inventors: S. Christopher Davis, Richard J. Fox, Vesna Mitchell, Gjalt W. Huisman, Lisa M. Newman
  • Ketoreductases and uses thereof
    Patent number: 8415127
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
    Type: Grant
    Filed: November 7, 2011
    Date of Patent: April 9, 2013
    Assignee: Codexis, Inc.
    Inventors: Charlene Ching, John M. Gruber, Gjalt W. Huisman, Emily Mundorff, Lisa M. Newman
  • Biocatalytic Processes for the Preparation of Stereomerically Pure Fused Bicyclic Proline Compounds
    Publication number: 20120244581
    Abstract: The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M?, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
    Type: Application
    Filed: March 30, 2012
    Publication date: September 27, 2012
    Applicant: CODEXIS, INC.
    Inventors: Benjamin Mijts, Sheela Muley, Jack Liang, Lisa M. Newman, Xiyun Zhang, James Lalonde, Michael D. Clay, Jun Zhu, John M. Gruber, Jeffrey Colbeck, John D. Munger, JR., Jagadeesh Mavinahalli, Roger Sheldon
  • Ketoreductases and Uses Thereof
    Publication number: 20120178142
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
    Type: Application
    Filed: November 7, 2011
    Publication date: July 12, 2012
    Applicant: CODEXIS, INC.
    Inventors: Charlene Ching, John M. Gruber, Gjalt W. Huisman, Emily Mundorff, Lisa M. Newman
  • Stereomerically Pure Fused Bicyclic Proline Compounds Useful for Preparing Hepatitis C Protease Inhibitors
    Publication number: 20120130087
    Abstract: The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M?, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.
    Type: Application
    Filed: November 11, 2011
    Publication date: May 24, 2012
    Applicant: CODEXIS, INC.
    Inventors: Benjamin Mijts, Sheela Muley, Jack Liang, Lisa M. Newman, Xiyun Zhang, James Lalonde, Michael D. Clay, Jun Zhu, John M. Gruber, Jeffrey Colbeck, John D. Munger, JR., Jagadeesh Mavinahalli, Roger Sheldon
  • Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds
    Patent number: 8178333
    Abstract: The present disclosure provides monoamine oxidase enzymes and methods of their use in biocatalytic processes for the preparation of substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M?, and R5 are as described herein.
    Type: Grant
    Filed: June 23, 2009
    Date of Patent: May 15, 2012
    Assignee: Codexis, Inc.
    Inventors: Benjamin Mijts, Sheela Muley, Jack Liang, Lisa M. Newman, Xiyun Zhang, James Lalonde, Michael D. Clay, Jun Zhu, John M. Gruber, Jeffrey Colbeck, John D. Munger, Jr., Jagadeesh Mavinahalli, Roger Sheldon
  • Beta-Glucosidase Variants
    Publication number: 20120077216
    Abstract: The invention relates to recombinantly produced ?-Glucosidase Variants with enhanced thermoactivity compared to naturally occurring proteins. The invention also provides methods for producing a variant ?-glucosidase polypeptide with improved thermoactivity by identifying performance sensitive positions in a target ?-glucosidase polypeptide and substituting the residue at that position with a thermoactivity enhancing residue.
    Type: Application
    Filed: June 16, 2010
    Publication date: March 29, 2012
    Applicant: Codexis, Inc.
    Inventors: Xiyun Zhang, Jie Yang, Dipnath Baidyaroy, Sally Rhiannon Postlethwaite, Attila Andor, Louis Clark, Lisa M. Newman
  • BETA-GLUCOSIDASE VARIANT ENZYMES AND RELATED POLYNUCLEOTIDES
    Publication number: 20120015408
    Abstract: The invention provides variants of the Thermoanaerobacter brockii CglT beta-glucosidase that have improve beta-glucosidase activity compared to the wild type enzyme. The invention also provides polynucleotides that encode the variants, as well as methods of producing the variants, enzyme compositions comprising the variants, and methods for using the variants in industrial applications.
    Type: Application
    Filed: February 26, 2010
    Publication date: January 19, 2012
    Applicant: CODEXIS, INC.
    Inventors: Dipnath Baidyaroy, Louis Clark, Lisa M. Newman, Charlene Ching
  • Ketoreductases and uses thereof
    Patent number: 8071347
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
    Type: Grant
    Filed: September 14, 2010
    Date of Patent: December 6, 2011
    Assignee: Codexis, Inc.
    Inventors: Charlene Ching, John M. Gruber, Gjalt W. Huisman, Emily Mundorff, Lisa M. Newman
  • Ketoreductases and Uses Thereof
    Publication number: 20110165670
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
    Type: Application
    Filed: September 14, 2010
    Publication date: July 7, 2011
    Applicant: CODEXIS, INC.
    Inventors: Charlene Ching, John M. Gruber, Gjalt W. Huisman, Emily Mundorff, Lisa M. Newman
  • RECOMBINANT THERMOASCUS AURANTIACUS BETA-GLUCOSIDASE VARIANTS FOR PRODUCTION OF FERMENTABLE SUGARS FROM CELLULOSIC BIOMASS
    Publication number: 20110124058
    Abstract: The present invention provides compositions and methods for the expression of recombinant ?-glucosidase variants, as well as their use in the production of fermentable sugars from cellulosic biomass.
    Type: Application
    Filed: November 19, 2010
    Publication date: May 26, 2011
    Applicant: CODEXIS, INC.
    Inventors: Dipnath Baidyaroy, Louis Clark, Lisa M. Newman
  • Ketoreductases and uses thereof
    Patent number: 7820421
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
    Type: Grant
    Filed: February 8, 2008
    Date of Patent: October 26, 2010
    Assignee: Codexis, Inc.
    Inventors: Charlene Ching, John M. Gruber, Gjalt W. Huisman, Emily Mundorff, Lisa M. Newman
  • Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives
    Patent number: 7807423
    Abstract: The present invention provides methods and compositions for preparing 4-substituted 3-hydroxybutyric acid derivatives by halohydrin dehalogenase-catalyzed conversion of 4-halo-3-hydroxybutyric acid derivatives. The present invention further provides methods and compositions for preparing 4-halo-3-hydroxybutyric acid derivatives by ketoreductase-catalyzed conversion of 4-halo-3-ketobutyric acid derivatives The present invention also provides methods and compositions for preparing vicinal cyano, hydroxyl substituted carboxylic acid esters.
    Type: Grant
    Filed: August 10, 2006
    Date of Patent: October 5, 2010
    Assignee: Codexis, Inc.
    Inventors: S. Christopher Davis, John H. Grate, David R. Gray, John M. Gruber, Gjalt W. Huisman, Steven K. Ma, Lisa M. Newman, Roger Sheldon, Li A Wang