Patents by Inventor Lisa MAHNKE

Lisa MAHNKE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMBINATION OF A BCL-2 INHIBITOR AND A HYPOMETHYLATING AGENT FOR TREATING CANCERS, USES AND PHARMACEUTICAL COMPOSITIONS THEREOF
    Publication number: 20230270748
    Abstract: A combination comprising a Bcl-2 inhibitor with a hypomethylating agent, uses in the treatment of cancers and pharmaceutical compositions thereof. The Bcl-2 inhibitor is 5-(5-chloro-2-{[(3S)-3-(morpholin-4-ylmethyl)-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}phenyl)-N-(5-cyano-1,2-dimethyl-1H-pyrrol-3-yl)-N-(4-hydroxyphenyl)-1,2-dimethyl-1H-pyrrole-3-carboxamide and the hypomethylating agent is selected from decitabine, azacitidine and guadecitabine.
    Type: Application
    Filed: July 30, 2021
    Publication date: August 31, 2023
    Inventors: Emmelyne DESSEIN, Lisa MAHNKE, Michael Robert COOPER
  • BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR NECTIN-4 AND USES THEREOF
    Publication number: 20230181749
    Abstract: The present invention relates to a Bicycle toxin conjugate BT8009, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof, and uses thereof. In one embodiment, the pharmaceutical composition comprises BT8009, histidine, sucrose and Polysorbate 20. In another embodiment, the pharmaceutical composition is for use in treating an advanced solid tumor malignancy associated with Nectin-4-expression in a patient, preferably in combination with Nivolumab.
    Type: Application
    Filed: May 20, 2021
    Publication date: June 15, 2023
    Inventors: Amy Katherine DICKSON, Darren LIMB, Lisa MAHNKE, Michael RIGBY, Terrence Allen WEST, David WITTY
  • BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR EphA2 AND USES THEREOF
    Publication number: 20230025916
    Abstract: The present invention relates to a Bicycle toxin conjugate BT5528, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof, and uses thereof.
    Type: Application
    Filed: November 27, 2020
    Publication date: January 26, 2023
    Inventors: Gavin BENNETT, Lisa MAHNKE