Patents by Inventor Lisa Marie Newman

Lisa Marie Newman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ketoreductase polypeptides and related polynucleotides
    Patent number: 7833767
    Abstract: The present invention is directed to variant polypeptides having enhanced ketoreductase activity and/or thermostability for use in the stereospecific reduction of ketones. In addition, the present invention is directed to polynucleotides that encode the ketoreductase polypeptides, including codon optimized versions of the polynucleotides which provide for enhanced expression in host cells. In another aspect, the present invention is directed to nucleotide constructs, vectors and host cells that are transformed with polynucleotides of the present invention.
    Type: Grant
    Filed: October 8, 2009
    Date of Patent: November 16, 2010
    Assignee: Codexis, Inc.
    Inventors: S. Christopher Davis, Gjalt W. Huisman, Stephane J. Jenne, Anke Krebber, Lisa Marie Newman
  • Halohydrin dehalogenases and related polynucleotides
    Patent number: 7824898
    Abstract: The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.
    Type: Grant
    Filed: August 11, 2004
    Date of Patent: November 2, 2010
    Assignee: Codexis, Inc.
    Inventors: S. Christopher Davis, Richard John Fox, Gjalt W. Huisman, Vesna Gavrilovic, Lisa Marie Newman
  • Glucose dehydrogenase polypeptides and related polynucleotides
    Patent number: 7816111
    Abstract: The present invention is directed to glucose dehydrogenase (GDH) polypeptides that have enhanced GDH activity and/or thermostability relative to the backbone wild-type glucose dehydrogenase polypeptide. In addition, the present invention is directed to a polynucleotide that encodes for the GDH polypeptides of the present invention, to nucleic acid sequences comprising the polynucleotides, to expression vectors comprising the polynucleotides operatively linked to a promoter, to host cells transformed to express the GDH polypeptides, and to a method for producing the GDH polypeptides of the present invention.
    Type: Grant
    Filed: August 11, 2004
    Date of Patent: October 19, 2010
    Assignee: Codexis, Inc.
    Inventors: S. Christopher Davis, Stephane J. Jenne, Anke Kebber, Lisa Marie Newman
  • HALOHYDRIN DEHALOGENASES AND RELATED POLYNUCLEOTIDES
    Publication number: 20100167345
    Abstract: The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.
    Type: Application
    Filed: October 5, 2009
    Publication date: July 1, 2010
    Applicant: CODEXIS, INC.
    Inventors: S. Christopher Davis, Richard John Fox, Gjalt W. Huisman, Vesna Gavrilovic, Lisa Marie Newman
  • KETOREDUCTASE POLYPEPTIDES AND RELATED POLYNUCLEOTIDES
    Publication number: 20100028972
    Abstract: The present invention is directed to variant polypeptides having enhanced ketoreductase activity and/or thermostability for use in the stereospecific reduction of ketones. In addition, the present invention is directed to polynucleotides that encode the ketoreductase polypeptides, including codon optimized versions of the polynucleotides which provide for enhanced expression in host cells. In another aspect, the present invention is directed to nucleotide constructs, vectors and host cells that are transformed with polynucleotides of the present invention.
    Type: Application
    Filed: October 8, 2009
    Publication date: February 4, 2010
    Applicant: CODEXIS, INC.
    Inventors: S. Christopher Davis, Gjalt W. Huisman, Stephane J. Jenne, Anke Krebber, Lisa Marie Newman
  • Ketoreductase polypeptides and related polynucleotides
    Patent number: 7629157
    Abstract: The present invention is directed to variant polypeptides having enhanced ketoreductase activity and/or thermostability for use in the stereospecific reduction of ketones. In addition, the present invention is directed to polynucleotides that encode the ketoreductase polypeptides, including codon optimized versions of the polynucleotides which provide for enhanced expression in host cells. In another aspect, the present invention is directed to nucleotide constructs, vectors and host cells that are transformed with polynucleotides of the present invention.
    Type: Grant
    Filed: August 11, 2004
    Date of Patent: December 8, 2009
    Assignee: Codexis, Inc.
    Inventors: S. Christopher Davis, Gjalt W. Huisman, Stephane J. Jenne, Anke Kebber, Lisa Marie Newman
  • Halohydrin dehalogenases and related polynucleotides
    Patent number: 7588928
    Abstract: The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.
    Type: Grant
    Filed: November 2, 2005
    Date of Patent: September 15, 2009
    Assignee: Codexis, Inc.
    Inventors: S. Christopher Davis, Richard John Fox, Gjalt W. Huisman, Vesna Gavrilovic, Emily C. Mundorff, Lisa Marie Newman
  • Halohydrin dehalogenases and related polynucleotides
    Patent number: 7541171
    Abstract: The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.
    Type: Grant
    Filed: February 23, 2005
    Date of Patent: June 2, 2009
    Assignee: Codexis, Inc.
    Inventors: S. Christopher Davis, Richard John Fox, Gjalt W. Huisman, Vesna Gavrilovic, Lisa Marie Newman
  • COMPOSITIONS AND METHODS FOR PRODUCING STEREOISOMERICALLY PURE STATINS AND SYNTHETIC INTERMEDIATES THEREFOR
    Publication number: 20080248539
    Abstract: The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, method of using the engineered ketoreductase enzymes to synthesize a variety of chirally pure compounds, and the chirally pure compounds prepared therewith.
    Type: Application
    Filed: October 1, 2007
    Publication date: October 9, 2008
    Applicant: Codexis, Inc.
    Inventors: Lorraine Joan Giver, Lisa Marie Newman, Emily Mundorff, Gjalt W. Huisman, Stephane J. Jenne, Jun Zhu, Behnaz Behrouzian, John H. Grate, James Lalonde