Patents by Inventor Lisa Nader

Lisa Nader has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protein and peptide delivery to mammalian cells in vitro
    Patent number: 7476401
    Abstract: Compositions and methods for delivery of proteins and peptides to mammalian cells in vitro are described. Specifically, polypeptide-surfactant complexes formed from noncovalent hydrophobation of polypeptides and reversible hydrophobic modification of polypeptides are described. The compositions can be used to delivery positively charged, negatively charged and charge neutral polypeptides to cells.
    Type: Grant
    Filed: October 12, 2005
    Date of Patent: January 13, 2009
    Assignee: Mirus Bio LLC
    Inventors: Sean D. Monahan, Vladimir G. Budker, Kirk Ekena, Lisa Nader
  • Protein and peptide delivery to mammalian cells in vitro
    Publication number: 20060034909
    Abstract: Compositions and methods for delivery of proteins and peptides to mammalian cells in vitro are described. Specifically, polypeptide-surfactant complexes formed from noncovalent hydrophobation of polypeptides and reversible hydrophobic modification of polypeptides are described. The compositions can be used to delivery positively charged, negatively charged and charge neutral polypeptides to cells.
    Type: Application
    Filed: October 12, 2005
    Publication date: February 16, 2006
    Inventors: Sean Monahan, Vladimir Budker, Kirk Ekena, Lisa Nader
  • Polymerized formamides for use in delivery of compounds to cells
    Publication number: 20050265957
    Abstract: The invention provides for polycations for condensation and delivery of polynucleotides to cells. Processes for forming the polycations by the polymerization of formamide monomers is also described.
    Type: Application
    Filed: April 8, 2005
    Publication date: December 1, 2005
    Inventors: Sean Monahan, Lisa Nader, Vladimir Budker, James Hagstrom, Paul Slattum, Jon Wolff
  • Covalent modification of RNA for in vitro and in vivo delivery
    Publication number: 20040167090
    Abstract: The post-synthetic modification of RNA for the delivery of the RNA to a mammalian cell is described. The modifications enhance resistant of the RNA to nuclease digestion and delivery of the RNA to the cell whether the RNA is delivered alone or in combination with a transfection agent. Activity of the RNA in the cell is maintained.
    Type: Application
    Filed: February 19, 2004
    Publication date: August 26, 2004
    Inventors: Sean D. Monahan, Vladimir G. Budker, Lisa Nader, Vladimir Subbotin, Jon A. Wolff
  • Protein and peptide delivery to mammalian cells in vitro
    Publication number: 20040151766
    Abstract: Compositions and methods for delivery of proteins and peptides to mammalian cells in vitro are described. Specifically, polypeptide-surfactant complexes formed from noncovalent hydrophobation of polypeptides and reversible hydrophobic modification of polypeptides are described. The compositions can be used to delivery positively charged, negatively charged and charge neutral polypeptides to cells.
    Type: Application
    Filed: January 29, 2004
    Publication date: August 5, 2004
    Inventors: Sean D. Monahan, Vladimir G. Budker, Kirk Ekena, Lisa Nader
  • Novel methods for the delivery of polynucleotides to cells
    Publication number: 20030235916
    Abstract: Process are described for the delivery of a polynucleotide to a cell. The process comprises forming a salt stable complex between the polynucleotide and a cationic surfactant. Ternary complexes are also made by associating an amphipathic compound with the binary complex. The resultant complexes are suitable for delivery of the polynucleotide to cells in vitro and in vivo.
    Type: Application
    Filed: June 16, 2003
    Publication date: December 25, 2003
    Inventors: Sean D. Monahan, Lisa Nader, Jon A. Wolff, Vladimir G. Budker, James E. Hagstrom