Abstract: The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the number of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment; and when reconstituted, has reduced complement activation (C5A, C3A).

Abstract: The spray dried plasma by the nature of its characteristics and the process by which it is made allows for a dried plasma with reduced pathogens. It has at least three aspects of pathogen reduction that results in a plasma product with reduced or no pathogens. The first aspect relates to a spray drying disposable and machine that eliminates or minimizes the introduction of pathogens into the spray drying process and is referred to as the anti-contamination process. The second aspect of pathogen reduction relates to the spray drying process and parameters that reduces pathogens that may be present in the donor plasma, and/or inhibit pathogen growth and/or pathogen proliferation introduced by the donor plasma. The third aspect results in reduced pathogens occurring during storage of the dried plasma wherein the manufacturing and storage conditions are such that pathogens are reduced, and/or pathogen growth and/or pathogen proliferation are inhibited.

Abstract: The present invention relates to a spray dried plasma composition having one or more of the following characteristics: when reconstituted, largely amorphous and has no cholesterol crystals; when reconstituted, the mean size of large particulates is reduced; has low residual moisture; reconstitutes rapidly in under four minutes; highly stable when stored under refrigeration, at room temperature or at elevated temperatures and allows for storage for longer periods of time; when reconstituted, exhibits recovery of the most fragile of proteins, including von Willebrand's factor; when reconstituted with Sterile Water for Injection (SWFI), reconstituted plasma is at a pH that is near normal plasma pH, and does so without treatment or storage in CO2 or other pH adjustment.

Abstract: A method of treating plasma with a pretreatment solution that has a physiologically compatible spray dry stable acidic substance (SDSAS) and an amino acid, prior to or contemporaneously with spray drying of the plasma that results in greater recovery and greater long-term stabilization of the dried plasma proteins as compared to spray dried plasma that has not be subject to the formulation method of the present invention, as well as compositions related to plasma dried by the methods of the present invention.

Abstract: A display for displaying an image to a viewer, capable of highlighting specific locations selected by a user. This display comprises: a) a punchable layer such as a foam board having a first surface and a second surface, b) an image affixed to the first surface of the punchable layer. The punchable layer and the image form a sandwich dubbed display cover which is partially transparent and is observed by a viewer located on the image side of the display cover, c) a light source illuminating the second surface of the punchable layer, d) a piercing means for enabling the user to punch at least one hole into the punchable layer, and e) a plurality of pegs equal in number to the number of holes.

Abstract: A display for displaying an image to a viewer, capable of highlighting specific locations selected by a user. This display comprises: a) a punchable layer such as a foam board having a first surface and a second surface, b) an image affixed to the first surface of the punchable layer. The punchable layer and the image form a sandwich dubbed display cover which is partially transparent and is observed by a viewer located on the image side of the display cover, c) a light source illuminating the second surface of the punchable layer, d) a piercing means for enabling the user to punch at least one hole into the punchable layer, and e) a plurality of pegs equal in number to the number of holes.

Abstract: A perpetual seal card game in which players purchase individual play cards and reveal indicia covered by removable covers. Indicia on the individual play cards indicate whether the player is an instant winner, continues playing as a challenging player or has lost the game. If the player is an instant winner, he receives a prize and is finished playing the game. If the player is a challenging player, he has an opportunity to challenge the prior game's winner. The challenging players identify themselves on a seal card containing a challenging player identification area and predetermined challenger indicia concealed by a removable cover. Once all of the challenging players have identified themselves, the predetermined challenger indicia is disclosed identifying the player who will challenge the prior game's winner. A second seal card, containing concealed indicia identifying the winner of the game, is used to determine the winner of the game.