Patents by Inventor Lisa Purcell Ngambo

Lisa Purcell Ngambo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for Enhancing Efficacy of a Vaccine by Administering an IL-4R Antagonist
    Publication number: 20170239342
    Abstract: The present invention provides methods for enhancing the efficacy and/or safety of a vaccine. In certain embodiments, the invention provides methods to increase or potentiate the immune response to a vaccine in a subject in need thereof. The methods of the present invention comprise administering to a subject in need thereof an interleukin-4 receptor (IL-4R) antagonist such as an anti-IL-4R antibody in combination with said vaccine. In certain embodiments, the methods of the present invention are used to afford enhanced protection to an infectious disease such as whooping cough.
    Type: Application
    Filed: February 17, 2017
    Publication date: August 24, 2017
    Inventors: Lisa Purcell Ngambo, Neil Graham, Andrew J. Murphy, Robert Evans
  • Methods for treating or preventing influenza virus infection by administering a serine protease inhibitor
    Patent number: 9498529
    Abstract: The present invention provides methods for treating or preventing influenza virus infection. The methods of the present invention comprise administering to a subject in need thereof a pharmaceutical composition comprising a type II transmembrane serine protease (TTSP) inhibitor. The TTSP inhibitor preferably functions by inhibiting the proteolytic cleavage of influenza hemagglutinin (HA0) into the functional subunits HA1 and HA2. In certain embodiments, the TTSP inhibitor is an inhibitor of transmembrane protease serine S1 member 2 (TMPRSS2), such as an anti-TMPRSS2 antibody or antigen-binding fragment thereof.
    Type: Grant
    Filed: April 15, 2013
    Date of Patent: November 22, 2016
    Assignee: REGENERON PHARMACEUTICALS, INC.
    Inventor: Lisa A. Purcell Ngambo
  • Human Antibodies to Influenza Hemagglutinin
    Publication number: 20160176953
    Abstract: The present invention provides monoclonal antibodies, or antigen-binding fragments thereof, that bind to the influenza hemagglutinin (HA) protein, pharmaceutical compositions comprising the antibodies and methods of use. The antibodies of the invention are useful for inhibiting or neutralizing influenza virus activity, thus providing a means of treating or preventing influenza infection in humans. In some embodiments, the invention provides for use of one or more antibodies that bind to the influenza HA for preventing viral attachment and/or entry into host cells. The antibodies of the invention may be used prophylactically or therapeutically and may be used alone or in combination with one or more other anti-viral agents or vaccines.
    Type: Application
    Filed: December 18, 2015
    Publication date: June 23, 2016
    Inventors: Lisa A. Purcell Ngambo, Jonathan Viau, William Olson
  • Methods for treating malaria by administering an antibody that specifically binds angiopoietin-2 (ang-2)
    Patent number: 9371379
    Abstract: The present invention provides methods for treating malaria by administering to a patient in need thereof a pharmaceutical composition comprising an antibody that specifically binds human angiopoietin-2 (Ang-2).
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: June 21, 2016
    Inventors: Gavin Thurston, Christopher Daly, Lisa Purcell Ngambo
  • Methods for Treating or Preventing Malaria by Administering an Antibody that Specifically Binds Angiopoietin-2 (Ang-2)
    Publication number: 20140112930
    Abstract: The present invention provides methods for treating or preventing malaria by administering to a patient in need thereof a pharmaceutical composition comprising an antibody that specifically binds human angiopoietin-2 (Ang-2).
    Type: Application
    Filed: December 19, 2013
    Publication date: April 24, 2014
    Applicant: Regeneron Pharmaceuticals, Inc.
    Inventors: Gavin Thurston, Christopher Daly, Lisa Purcell Ngambo
  • METHODS FOR TREATING OR PREVENTING INFLUENZA VIRUS INFECTION BY ADMINISTERING A SERINE PROTEASE INHIBITOR
    Publication number: 20130273070
    Abstract: The present invention provides methods for treating or preventing influenza virus infection. The methods of the present invention comprise administering to a subject in need thereof a pharmaceutical composition comprising a type II transmembrane serine protease (TTSP) inhibitor. The TTSP inhibitor preferably functions by inhibiting the proteolytic cleavage of influenza hemagglutinin (HA0) into the functional subunits HA1 and HA2. In certain embodiments, the TTSP inhibitor is an inhibitor of transmembrane protease serine S1 member 2 (TMPRSS2), such as an anti-TMPRSS2 antibody or antigen-binding fragment thereof.
    Type: Application
    Filed: April 15, 2013
    Publication date: October 17, 2013
    Applicant: REGENERON PHARMACEUTICALS, INC.
    Inventor: Lisa A. PURCELL NGAMBO
  • Methods for Treating or Preventing Malaria by Administering an Antibody that Specifically Binds Angiopoietin-2 (Ang-2)
    Publication number: 20120189635
    Abstract: The present invention provides methods for treating or preventing malaria by administering to a patient in need thereof a pharmaceutical composition comprising an antibody that specifically binds human angiopoietin-2 (Ang-2).
    Type: Application
    Filed: March 12, 2012
    Publication date: July 26, 2012
    Applicant: Regeneron Pharmaceuticals, Inc.
    Inventors: Gavin Thurston, Christopher Daly, Lisa Purcell Ngambo