Patents by Inventor Lisa S. Bouchard

Lisa S. Bouchard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for the oral delivery of therapeutic agents
    Patent number: 5451411
    Abstract: Alginate beads are employed as a site specific oral delivery system for cationic therapeutic agents, such as TGF-.beta..sub.1, designed to target the agents to the luminal side of the small intestine. Improved delivery of bioactive material is obtained by: 1) incorporating selected polyanions in the alginate beads to shield the cationic therapeutic agent from interaction with alginate and/or 2) acid treating alginate beads containing the therapeutic agents to reduce the molecular weight of alginate and its interaction with the agents. Enhanced bioactivity of therapeutic agents released from the alginate is attributed to the ability of polyacrylic acid to shield the agents from interaction with lower molecular fragments of acid treated alginate.
    Type: Grant
    Filed: October 15, 1993
    Date of Patent: September 19, 1995
    Assignees: University of Washington, Bristol Myers Squibb Company
    Inventors: Wayne R. Gombotz, Russell J. Mumper, Allan S. Hoffman, Lisa S. Bouchard