Abstract: The present disclosure provides for endonuclease enzymes having distinguishing domain features, as well as methods of using such enzymes or variants thereof.

Abstract: The present disclosure relates to methods, products and systems for the prognosis of subjects suffering from multiple myeloma. In certain embodiments, the present disclosure provides a method of prognosis for a subject suffering from multiple myeloma. The method comprises determining the level of desmoglein 2 (DSG2) in malignant plasma cells from the subject, wherein an increased level of DSG2 in the plasma cells is indicative of a poorer prognosis for the subject.

Abstract: The present disclosure provides for endonuclease enzymes as well as methods of using such enzymes or variants thereof.

Abstract: Described herein are methods, compositions, and systems derived from uncultivated microorganisms useful for gene editing.

Abstract: A method of operating a device, which includes providing a user interface with a display artifact; in response to an indication a user selected to copy the display artifact, storing multiple levels of detail of the display artifact; allowing the user to paste a selected level of detail by steps of: in response to an indication a user selected an input field and a paste command, displaying a plurality of paste options for pasting the display artifact into the input field, wherein the plurality of paste options each have a unique level of detail for representing the display artifact; allowing the user to select from the plurality of paste options; and in response to an indication a user selected a paste option from the plurality of paste options, pasting the display artifact with a level of detail associated with the selected paste option into the input filed.

Abstract: The present disclosure relates to methods of feeding animals by providing feed additives that modulate the gut microbiome to improve the health, nutrition, and growth performance. The present disclosure further relates to methods of modulating the microbial species present in the gastrointestinal tract of an animal. Such modulation includes, for example, modulating the level or function of microbial species.

Abstract: A method of making synthetic polymer pellet feedstock having a high concentration of an anti-microbial agent includes the steps of: introducing a polymer into a mixing vessel; introducing a polysiloxane dispersant into the mixing vessel; introducing an anti-microbial agent comprised of a powdered metal material into the mixing vessel; heating and mixing the polymer, the polysiloxane dispersant and the anti-microbial agent to form a molten blend that exhibits a generally homogenous dispersal of the anti-microbial agent; extruding the molten blend to form filaments; and cutting the filaments to form metalized synthetic polymer pellet feedstock. The powdered metal material includes particles of silver in metallic or salt form measuring between about 2 micrometers and about 12 micrometers and particles of copper in metallic or salt form measuring between about 2 micrometers and about 12 micrometers.

Abstract: The combined toothpaste container cap and dental floss dispenser of the present disclosure and related inventions includes a cap structure configured to fit with a toothpaste dispenser in the form of a tube, a floss container and an access panel. The floss container is configured to fit within the cap body and has a floss containment cavity in which a supply of dental floss is stored. A floss lead opening is located on the floss container through which the dental floss is accessed. An access panel is attached to the floss container which covers the floss lead opening.